Interventional gastroenterology in oncology

Abstract

Cancer is one of the foremost health problems worldwide and is among the leading causes of death in the United States. Gastrointestinal tract cancers account for almost one third of the cancer‐related mortality globally, making it one of the deadliest groups of cancers. Early diagnosis and prompt management are key to preventing cancer‐related morbidity and mortality. With advancements in technology and endoscopic techniques, endoscopy has become the core in diagnosis and management of gastrointestinal tract cancers. In this extensive review, the authors discuss the role endoscopy plays in early detection, diagnosis, and management of esophageal, gastric, colorectal, pancreatic, ampullary, biliary tract, and small intestinal cancers.

Precise Photodynamic Therapy by Midkine Nanobody-Engineered Nanoparticles Remodels the Microenvironment of Pancreatic Ductal Adenocarcinoma and Potentiates the Immunotherapy

“…Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 85% of all pancreatic solid tumors with a dismal 5-year overall survival rate (<10%), and it is the fourth leading cause of cancer-related death worldwide. , Surgical resection remains the only curative treatment for early stage PDAC. However, only 10% to 20% of PDAC patients have indications for surgical removal since 80% of PDAC patients are diagnosed at the advanced stage with possible metastasis .…”