Intervention with Therapeutic Agents, Understanding the Path to Remission to Type 2 Diabetes

Hao, Shuai; Umpiérrez, Guillermo E.; Vellanki, Priyathama

doi:10.1016/j.ecl.2022.07.004

Cited by 2 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, metformin is the most prescribed noninsulin drug in Brazil, although the percentage of patients who use this therapy does not reach 5% of the total [7]. Current treatment of T2DM basically consists of changes in diet and lifestyle with the progressive addition of more complex antidiabetic regimens (including metformin, sulphonylureas, sodium-glucose cotransporter-2 inhibitors, thiazolidinediones, and so on) and eventually supplemental insulin therapy [8].…”

Section: Introductionmentioning

confidence: 99%

Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review

Sousa,

Viana,

Coêlho

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent years. Due to nature’s complex biosynthetic machinery, they also exhibit a reasonable degree of structural complexity/diversity for further analysis in structure-activity studies. Therefore, monoterpenes as antidiabetic agents have been investigated by recent in vitro and in vivo studies extensively reported in the scientific literature and claimed by patent documents. The purpose of this survey is to provide a comprehensive and prospective review concerning the potential applications of monoterpenes in the treatment of diabetes. The data for this research were collected through the specialized databases PubMed, Scopus, Web of Science, and ScienceDirect between the years 2014 and 2022, as well as the patent databases EPO, WIPO, and USPTO. The research used 76 articles published in the leading journals in the field. The main effect observed was the antidiabetic activity of monoterpenes. This review showed that monoterpenes can be considered promising agents for prevention and/or treatment of diabetes as well as have a marked pharmaceutical potential for the development of bioproducts for therapeutics applications.

show abstract

Section: Introductionmentioning

confidence: 99%