Intervention with education and exercise reverses the metabolic syndrome in adults

Mujica, Verónica; Urzúa, Alberto; Leiva, Elba; Díaz, Nora; Moore‐Carrasco, Rodrigo; Vásquez, Marcela; Rojas, Edgardo; Icaza, Gloria; Toro, C.G. Di; Orrego, Roxana; Palomo, Iván

doi:10.1016/j.jash.2010.02.008

Cited by 36 publications

(21 citation statements)

References 21 publications

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“…Future studies need to take these potential confounders of MetS development into consideration. Due to the convenient, comprehensive medical care in Taiwan, one limitation of this investigation is that we did not consider potential protective effects [73][74][75][76] of treatment among workers with abnormal MetS components over the 5-year study interval. Thus, we may have underrated the risk of shift work for increased risk of each MetS component.…”

Section: Metabolic Syndrome Component Count and Shift Work O R I G I mentioning

confidence: 99%

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Lin¹,

Hsieh²,

Chen³

2015

Int J Occup Med Environ Health

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Objectives: To establish a practical method for assessing the general metabolic health conditions among different employee groups, this study utilized the total count of metabolic syndrome (MetS) elements as a parameter, and performed a retrospective analysis comparing changes of MetS component count (MSC) of 5 years among day-time work (DW) and day-andnight rotating shift work (RSW) employees. Material and Methods: The data of personal histories, physical examinations, blood tests, abdominal sonographic examinations and occupational records were collected from a cohort of workers in an electronics manufacturing company. We first defined the arithmetic mean value of MSC as MSC density (MSCD) for the employee group; then we compared the changes of MSCD over 5 years between DW and RSW workers. Occupational, personal and health records were analyzed for the 1077 workers with an initial mean age of 32.4 years (standard deviation (SD): 6.2 years), including 565 RSW workers (52%). Results: The initial MSCDs were 1.26 and 1.12 (p = 0.06) for DW and RSW workers, respectively; after 5 years, the increments of MSCD for DW and RSW workers were 0.10 and 0.39, respectively (p < 0.01). By performing multivariate logistic regression analyses, and comparing with DW co-workers, final results indicated that the workers exposed to RSW have 1.7-fold increased risk of elevated MSCD (95% confidence interval (CI): 1.28-2.25, p < 0.01); and are 38% less likely (adjusted rate ratio (aRR) 0.62, 95% CI: 0.45-0.86, p < 0.01) to attain decreased MSCD. Conclusions: These observations demonstrate that changes of MSCD are significantly different between DW and RSW workers, and are increasingly associated with RSW exposure. In conclusion, MSCD can represent the general metabolic health conditions of a given employee group; MSC, MSCD and their transitional changes can be applied as simple and standardized tools for monitoring metabolic health risk profiles when managing employee health, at both the individual and company levels.

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Section: Metabolic Syndrome Component Count and Shift Work O R I G I mentioning

confidence: 99%

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Lin¹,

Hsieh²,

Chen³

2015

Int J Occup Med Environ Health

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“…The mean duration of the interventions was 5.2 ± 3.4 months, ranging from two months to one year. Appendix 1 shows the quality of the studies assessed according to the Cochrane tool 18 , and the description of studies with intention to treat 24,26,27,29,31 .…”

Section: Resultsmentioning

confidence: 99%

“…In that subgroup, six studies were assessed with a total of 511 participants. Of those, two studies have reported combined interventions 26,31 , which encourage healthy diets in association with the practice of physical exercises. Although not statistically significant, the grouped effect of the interventions proved to be solid, with a reduction in systolic arterial blood pressure (-3.17; 95% CI: -7.62 to 1.28; I 2 = 0.0%, p = 0.995).…”

Section: Resultsmentioning

confidence: 99%

Dietary Interventions and Blood Pressure in Latin America - Systematic Review and Meta-Analysis

Mazzaro¹,

Klostermann²,

Erbano³

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundHigh blood pressure is the major risk factor for cardiovascular disease. Low blood pressure control rates in Latin American populations emphasize the need for gathering evidence on effective therapies. ObjectiveTo evaluate the effects of dietary interventions on blood pressure in Latin American populations. MethodsSystematic review. Electronic databases (MEDLINE/PubMed, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, SciELO, LILACS and VHL) were searched and manual search for studies published up to April 2013 was performed. Parallel studies about dietary interventions in Latin American adult populations assessing arterial blood pressure (mm Hg) before and after intervention were included. ResultsOf the 405 studies identified, 10 randomized controlled trials were included and divided into 3 subgroups according to the proposed dietary intervention. There was a non-significant reduction in systolic blood pressure in the subgroups of mineral replacement (-4.82; 95% CI: -11.36 to 1.73) and complex pattern diets (-3.17; 95% CI: -7.62 to 1.28). Regarding diastolic blood pressure, except for the hyperproteic diet subgroup, all subgroups showed a significant reduction in blood pressure: -4.66 mmHg (95% CI: -9.21 to -0.12) and -4.55 mmHg (95% CI: -7.04 to -2.06) for mineral replacement and complex pattern diets, respectively. ConclusionAvailable evidence on the effects of dietary changes on blood pressure in Latin American populations indicates a homogeneous effect of those interventions, although not significant for systolic blood pressure. Samples were small and the quality of the studies was generally low. Larger studies are required to build robust evidence.

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“…However, there are key factors in MS regulation that depend on those transcription factors that, by responding and adapting to signals from the environment, are able to change the levels of relevant gene expression and thereby regulate energy expenditure, substrate metabolism and food consumption in MS (13,14). The genes expressed during the development of MS include various groups of genes: genes specific to adipose tissue, genes involved in the proliferation and differentiation of adipocytes and genes that code for insulin-receptor substrate proteins, amongst others (15).…”

Section: Gene Expression and The Metabolic Syndromementioning

confidence: 99%

Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)

et al. 2012

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Abstract. Metabolic syndrome is a combination of medical disorders including hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased waist circumference, and is associated with a higher risk of cardiovascular disease. An increase in adipose tissue mass is associated with the augmented secretion of certain adipokines, such as interleukin-6, tumor necrosis factor-α and resistin, which cause endothelial dysfunction (an increase in vasoconstrictor molecules and in the expression of adhesion molecules as well as a decrease of vasodilator molecules, amongst other features) and hemostasis alterations that also favor a prothrombotic state (increased fibrinogen and plasminogen activator inhibitor-1 concentrations and platelet activation/aggregation). This interaction between adipose tissue, endothelial cells and platelets is associated with an increase or decrease in the expression of several transcription factors (peroxisome proliferator-activated receptors, CCAAT-enhancer-binding proteins, carbohydrate responsive element-binding proteins and sterol regulatory element-binding proteins) that play a crucial role in the regulation of distinct metabolic pathways related to the metabolic syndrome. In the present review, we present the primary changes in adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome and their possible target sites at the gene expression level.

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Intervention with education and exercise reverses the metabolic syndrome in adults

Cited by 36 publications

References 21 publications

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Dietary Interventions and Blood Pressure in Latin America - Systematic Review and Meta-Analysis

Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review)

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