Intervention to Promote Patients' Adherence to Antimalarial Medication: A Systematic Review

Fuangchan, Anjana; Dhippayom, Teerapon; Kongkaew, Chuenjid

doi:10.4269/ajtmh.12-0598

Cited by 25 publications

(26 citation statements)

References 33 publications

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“… reported that the absence of a difference in adherence between the intervention and control groups was probably because the population under study consisted of soldiers who stayed together after returning from a malaria‐endemic area. Adherence to malaria prophylaxis has been reported to be inadequate, mainly because of adverse events and forgetfulness . As stated above, multifaceted interventions featuring interactive education and training help to promote adherence in a variety of diseases.…”

Section: Discussionmentioning

confidence: 99%

Does mHealth increase adherence to medication? Results of a systematic review

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Does mHealth increase adherence to medication? Results of a systematic review

et al. 2014

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“…Other interventions that have been shown to improve patient adherence to antimalarial drugs include packaging and community education. 46 ACTs are now mostly available in factory packaged unit dose packs blister packs with illustrated instructions, therefore additional room for improvement may be limited. One possible modification could be improved instructions in local languages.…”

Section: Discussionmentioning

confidence: 99%

Cluster Randomized Trial of Text Message Reminders to Retail Staff in Tanzanian Drug Shops Dispensing Artemether-Lumefantrine: Effect on Dispenser Knowledge and Patient Adherence

Bruxvoort¹,

Festo²,

Kalolella³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Artemisinin combination therapies are available in private outlets, but patient adherence might be compromised by poor advice from dispensers. In this cluster randomized trial in drug shops in Tanzania, 42 of 82 selected shops were randomized to receive text message reminders about what advice to provide when dispensing artemether-lumefantrine (AL). Eligible patients purchasing AL at shops in both arms were followed up at home and questioned about each dose taken. Dispensers were interviewed regarding knowledge of AL dispensing practices and receipt of the malaria-related text messages. We interviewed 904 patients and 110 dispensers from 77 shops. Although there was some improvement in dispenser knowledge, there was no difference between arms in adherence measured as completion of all doses (intervention 68.3%, control 69.8%, p [adjusted] = 0.6), or as completion of each dose at the correct time (intervention 33.1%, control 32.6%, p [adjusted] = 0.9). Further studies on the potential of text messages to improve adherence are needed.

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“…One study in Malawi used MEMS containers and found 100% adherence to artemether-lumefantrine (AL) by self-report and lower adherence (92%) by MEMS [ 8 ]. However, ACTs are now typically dispensed in blister packs designed to improve adherence [ 15 ] and look considerably different than MEMS containers. This may result in over-estimated adherence, as patients using MEMS are likely to be aware that their adherence is being monitored and their experience is no longer comparable to that of patients receiving unit doses in their customary packaging.…”

Section: Introductionmentioning

confidence: 99%

Measuring Patient Adherence to Malaria Treatment: A Comparison of Results from Self-Report and a Customised Electronic Monitoring Device

et al. 2015

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BackgroundSelf-report is the most common and feasible method for assessing patient adherence to medication, but can be prone to recall bias and social desirability bias. Most studies assessing adherence to artemisinin-based combination therapies (ACTs) have relied on self-report. In this study, we use a novel customised electronic monitoring device—termed smart blister packs—to examine the validity of self-reported adherence to artemether-lumefantrine (AL) in southern Tanzania.MethodsSmart blister packs were designed to look identical to locally available AL blister packs and to record the date and time each tablet was removed from packaging. Patients obtaining AL at randomly selected health facilities and drug stores were followed up at home three days later and interviewed about each dose of AL taken. Blister packs were requested for pill count and extraction of smart blister pack data.ResultsData on adherence from both self-report verified by pill count and smart blister packs were available for 696 of 1,204 patients. There was no difference between methods in the proportion of patients assessed to have completed treatment (64% and 67%, respectively). However, the percentage taking the correct number of pills for each dose at the correct times (timely completion) was higher by self-report than smart blister packs (37% vs. 24%; p<0.0001). By smart blister packs, 64% of patients completing treatment did not take the correct number of pills per dose or did not take each dose at the correct time interval.ConclusionSmart blister packs resulted in lower estimates of timely completion of AL and may be less prone to recall and social desirability bias. They may be useful when data on patterns of adherence are desirable to evaluate treatment outcomes. Improved methods of collecting self-reported data are needed to minimise bias and maximise comparability between studies.

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Intervention to Promote Patients' Adherence to Antimalarial Medication: A Systematic Review

Cited by 25 publications

References 33 publications

Does mHealth increase adherence to medication? Results of a systematic review

Does mHealth increase adherence to medication? Results of a systematic review

Cluster Randomized Trial of Text Message Reminders to Retail Staff in Tanzanian Drug Shops Dispensing Artemether-Lumefantrine: Effect on Dispenser Knowledge and Patient Adherence

Measuring Patient Adherence to Malaria Treatment: A Comparison of Results from Self-Report and a Customised Electronic Monitoring Device

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