Intervention Study for Primary Prevention of Oral Cancer Among 36 000 Indian Tobacco Users

Pc, Gupta; Jj, Pindborg; Bhonsle, R. B.; Murti, P. R.; Mehta, Fali S.; Aghi, Mira; Daftary, D. K.; Shah, H.; Sinor, P. N.

doi:10.1016/s0140-6736(86)91386-3

Cited by 107 publications

(74 citation statements)

References 7 publications

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“…Our study is probably one of the first studies conducted in India to identify the predictors of quit attempts by tobacco users in India though predictors of tobacco consumption has been studied (Rani, 2003) and some community interventions for tobacco cessation have been conducted and evaluated (Gupta et al, 1986;Anantha et al, 1994;Arora, 2011) earlier. Recently some attempts have been made to assess nicotine dependence levels among smokers (Jayakrishnan et al, 2012) in India and measures of nicotine dependence among smokeless tobacco users have also been suggested (Jena, 2012) to characterize population groups.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Tobacco Cessation Behaviour among Smokers and Smokeless Tobacco Users in the States of Gujarat and Andhra Pradesh, India

Sarkar

Arora²,

Gupta³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Determinants of Tobacco Cessation Behaviour among Smokers and Smokeless Tobacco Users in the States of Gujarat and Andhra Pradesh, India

Sarkar

Arora²,

Gupta³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Tobacco use annually kills over one million Indians [3]. However, quitting is not a common practice in India due to a lack of widely available cessation support resources and few social norms to support quitting [2, 4,[7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Tobacco Use among Manufacturing Workers: Findings from the Baseline Survey of the Mumbai Worksite Tobacco Control Study

S¹,

M²,

Pawar³

et al. 2016

J Prev Med

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Objectives: To explore the potential role of the work context associated with tobacco use patterns among manufacturing workers in India Methods: We used cross-sectional survey data from the Mumbai Worksite Tobacco Control Study. Workers from manufacturing worksites in the greater Mumbai region were surveyed from 20 worksites that were recruited between July 2012 and July 2013 on rolling basis for a randomized controlled trial.Results: A total of 6880 workers out of 7633 that employed in 20 manufacturing worksites were surveyed. Current tobacco use was higher among production (23.5%) than non-production (19.2%) workers. In contrast, past tobacco use was somewhat lower among production (6.2%) than non-production (8.4%) workers. Production workers who used smokeless tobacco were twice as likely to report their workplaces did not have a policy or rule prohibiting tobacco use as compared to smokers or non-tobacco users. The prevalence of past tobacco use -compared to current use -was associated with workers' education, economic index and number of co-workers using tobacco. Conclusions:The current study underscores the important role of co-workers and worksite tobacco control policies (that cover both smoking and smokeless forms) to support reductions in tobacco use among manufacturing workers.

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“…Every year, 200,000 people are affected by oral cancer, worldwide. Moreover, the incidence in India where there is a tradition of tobacco chewing is 10 times higher than that in Japan 7,8,26,42) . This suggests that a comparison of data on lifestyle habits and cancer-associated genes in areas with a high rate of oral cancers with data on the Japanese population offers a way to obtain a better understanding of the underlying mechanisms of this disease.…”

Section: Discussionmentioning

confidence: 96%

Loss of Heterozygosity (LOH) on Chromosomes 2q, 3p and 21q in Indian Oral Squamous Cell Carcinoma

Yamamoto

Kuroiwa

Katakura

et al. 2007

Bull. Tokyo Dent. Coll.

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Around the world, 200,000 people a year are affected by oral cancer, and the incidence of this disease is 10 times higher in India than Japan, mainly due to the custom of chewing tobacco. Loss of heterozygosity (LOH) on the long arm of chromosome 2 (2q), the short arm of chromosome 3 (3p) and the long arm of chromosome 21 (21q) are observed in several human cancers. We identified novel tumor suppressor loci on these regions in primary oral squamous cell carcinomas (OSCCs) in Japanese. However, there has been no detailed analysis of LOH on these chromosomes in Indians. In the present study, we investigated LOH at 2q, 3p and 21q using 9 microsatellite markers in 26 Indian OSCCs. LOH was detected in 25 (96.2%) out of 26 informative samples at one or more of the loci examined. On the basis of the results, two commonly deleted regions were identified and a detailed deletion map was constructed. In the first region, a high frequency of LOH was observed at the D3S1007 locus (53.8%) on 3p25, which is located in the region neighboring the VHL (von Hippel-Lindau) gene. In the second region, LOH was concentrated at the D3S966 locus (50.0%) on 3p21.3, suggesting the presence of a putative tumor suppressor gene (TSG) associated with OSCCs. These results strongly suggest that there are at least two candidate TSGs located on chromosome 3p, and that alteration in them is associated with the tumorigenesis of OSCCs.

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Intervention Study for Primary Prevention of Oral Cancer Among 36 000 Indian Tobacco Users

Cited by 107 publications

References 7 publications

Determinants of Tobacco Cessation Behaviour among Smokers and Smokeless Tobacco Users in the States of Gujarat and Andhra Pradesh, India

Determinants of Tobacco Cessation Behaviour among Smokers and Smokeless Tobacco Users in the States of Gujarat and Andhra Pradesh, India

The Prevalence of Tobacco Use among Manufacturing Workers: Findings from the Baseline Survey of the Mumbai Worksite Tobacco Control Study

Loss of Heterozygosity (LOH) on Chromosomes 2q, 3p and 21q in Indian Oral Squamous Cell Carcinoma

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