Intervention studies in adenoma patients

Armitage, N. C.

doi:10.1007/bf01658957

Cited by 6 publications

(1 citation statement)

References 52 publications

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“…From the published reports it is therefore still impossible to devise a method, even in these unique populations, for sustaining polyp regression, prevention of polyp recurrence, or cancer occurrence. Interventions in patients with sporadic colorectal polyps are also presented in Table Many other dietary intervention studies have been reported [62] which use as endpoints parameters that only imperfectly predict neoplastic risk, usually measures of mucosal proliferative activity. Since they have shed virtually no light on the primary causes of colonic adenomas, they will not be summarized here.…”

Section: Diet and Adenoma Risk Cross Cultural Geographical Observationsmentioning

confidence: 99%

Diet and adenomatous polyp risk

Nelson

1994

Seminars in Surgical Oncology

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Studies of risk factors for colonic adenomatous polyps have been reported in greater numbers in 1993 than in all previous years combined. This explosion in interest in polyps has not arisen because polyps themselves cause serious illness. They are in the vast majority of cases asymptomatic. However, adenomas have become the surrogate for colon cancer in a number of phase III dietary intervention trials. These trials were undertaken at a time when very little was known of adenoma risk factors. Data accumulated in the past 18 months in general demonstrate a similarity in risk factors for cancer and polyp. Since it has also been recently established that polypectomy diminishes colon cancer risk, the adenomatous polyp has been established as an ethical and convenient surrogate for cancer of the colon. Prevention of colorectal cancer is the goal of all the above studies, and it is hoped that the dietary intervention trials currently under way will generate the data that will make prevention possible.

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Section: Diet and Adenoma Risk Cross Cultural Geographical Observationsmentioning

confidence: 99%

Diet and adenomatous polyp risk

Nelson

1994

Seminars in Surgical Oncology

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Advances in screening for colorectal cancer

Mandel

1996

Advances in Cancer Screening

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Mandel

1997

Cancer and Metastasis Reviews

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Colorectal cancer occurs throughout the world. Little is known about the etiology of this disease, however, adequate data exist to recommend secondary prevention with mass screening of average risk asymptomatic people age 50 or over. Three randomized controlled trials of a guaiac test for fecal occult blood involving over 250,000 participants found significant reductions in colorectal cancer mortality from both annual and biennial screening. Results from observational studies are consistent with the results from the randomized trials. Therefore, a screening recommendation for a fecal occult blood testing can be justified based on the overwhelming scientific evidence. A compelling argument can be made to use an immunochemical rather than guaiac test, since data suggests that immunochemical tests may be more sensitive and more specific than guaiac tests. Colorectal cancer mortality reductions of at least 33% can be attained with annual fecal occult blood testing. Biennial screening will result in reductions of at least 15 to 20%. There is insufficient evidence to justify either flexible sigmoidoscopy or colonoscopy for mass screening of an average-risk asymptotic population. However, there is justification for colonoscopic evaluation of high-risk members of the population.

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Intervention studies in adenoma patients

Cited by 6 publications

References 52 publications

Diet and adenomatous polyp risk

Diet and adenomatous polyp risk

Advances in screening for colorectal cancer

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