Intervention of 4% salmon phospholipid on metabolic syndrome in mice based on colonic lipidomics analysis

Abstract

BACKGROUND The incidence of metabolic syndrome (MetS) is increasing, and n‐3 polyunsaturated fatty acids (PUFAs) in salmon (Oncorhynchus) phospholipids can effectively reduce the risk of MetS. RESULTS Under the intervention of 4% salmon phospholipid, the levels of fasting blood glucose (FBG), insulin, monocyte chemoattractant protein‐1 (MCP‐1), interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) were significantly reduced in the plasma of MetS mice, whereas adiponectin was significantly increased. By screening, we found that the 18 differential metabolites, consisting of seven triglycerides (TGs), six diglycerides (DGs), one phosphatidylethanolamine (PE), three sphingomyelins (SMs) and one eicosanoid, could be the key differential metabolites, and two metabolic pathways were significantly affected: glycerolipid metabolism and glycerophospholipid metabolism. CONCLUSION 4% salmon phospholipids could affect MetS by inhibiting insulin resistance, reducing inflammatory factors and promoting the synthesis of PE, yet the mechanism required further study. Our results could help in the treatment of MetS. © 2021 Society of Chemical Industry.

Dietary Interventions of Salmon and Silver Carp Phospholipids on Mice with Metabolic Syndrome Based on Lipidomics

“…This means that there may be certain substances in the oil that can affect metabolic syndrome. Salmon and catfish phospholipids are rich in N-3 polyunsaturated fatty acids (PUFAs) [ 6 , 7 , 8 ], because n-3 polyunsaturated fatty acids (PUFAs) can inhibit triglyceride levels and inhibit metabolic disorders, such as cardiovascular disease and obesity, including dyslipidemia and insulin resistance, and it has been reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) in the diet containing fish has a risk-reducing effect on the prevention of cardiovascular and cerebrovascular diseases, cancer, metabolic syndrome, and Parkinson’s syndrome [ 9 , 10 ]. Lipidomics is an emerging method for the comprehensive and systematic studies of multiple lipids [ 11 ].…”