Intervention effects of puerarin on blood stasis in rats revealed by a 1H NMR-based metabonomic approach

Therapeutic Effects of Chinese Medicine Herb Pair, Huzhang and Guizhi, on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats Revealed by Anti-Inflammatory Assessments and NMR-Based Metabonomics

“…Finally, 50 μ L of phosphate buffer (0.2 mol/L Na 2 HPO 4 -0.2 mol/L NaH 2 PO 4 , pH 7.4) and 50 μ L of D 2 O were mixed with the plasma. The D 2 O provided a field-frequency lock solvent for the NMR spectrometer [ 16 ].…”

Comprehensive metabolomics analysis based on UPLC-Q/TOF-MSEand the anti-COPD effect of different parts ofCelastrus orbiculatusThunb.

“…Meanwhile, metabolites with VIP value > 4.0 and p-value < 0.001 were considered as potential chemical markers. 30,31 Futhermore, permutation test was also performed to provide a reference distribution with the R 2 /Q 2 values to indicate statistical signicance. Finally, the analysis results were shown in Simca 15.0 soware (Umetrics, Malmö, Sweden).…”

Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model

“…The citrate cycle is the main approach for energy supply, which unies carbohydrate, fat and protein metabolism. 26 The creatine/creatine phosphate shuttle system plays an essential role in energy homeostasis. 27 Creatine kinase catalyzes the reaction of ADP with phosphocreatine to generate ATP, serving as fuel in the case of energy deciency.…”

“…Therefore, compared with the control group, the energy metabolism of model rats is enhanced. Moreover, it has been reported that citrate cycle intermediates are inammatory signals, 26 so the citrate cycle is regarded as the metabolic pathway related to inammation. The suppression of energy metabolism induces an insufficient supply for the heart, causing the disturbance of normal blood ow.…”