Intervention effects of four exercise modalities in nonalcoholic fatty liver disease：systematic review and Bayesian network meta-analysis

Zhou, Bojun; Huang, Gang; Ma, Fuhai

doi:10.37766/inplasy2021.8.0062

Cited by 10 publications

(14 citation statements)

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“…Our study found that AT + RT is the best for overall improvement of TC and TG in NAFLD patients. The results are consistent with previous studies [75]. For ALT and AST, we found that the best way to improve their exercise is AT and RT, respectively.…”

Section: Discussionsupporting

confidence: 93%

Effect of Different Exercise Modalities on Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-analysis

Peng,

Xue,

Zhang

et al. 2023

Preprint

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Physical exercise intervention can significantly improve the liver of patients with nonalcoholic fatty liver disease, but it is unknown which exercise mode has the best effect on liver improvement in NAFLD patients. Therefore, we systematically evaluated the effect of exercise therapy on liver and blood index function of NAFLD patients through network meta-analysis(NMA). Through systematic retrieval of PubMed, Cochrane Library, Web of Science, EBSCO, and CNKI(National Knowledge Infrastructure), two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies by means of databases from inception to December 2022. The NMA was performed using the inconsistency model. A total of 42 studies, 2070 NAFLD patients were included: aerobic training(n = 779), resistance training(n = 159), high-intensity interval training(n = 160), aerobic training + resistance training(n = 96). The results indicate that aerobic training + resistance training could significantly improve Serum total cholesterol (TC) (Surface under the cumulative ranking curve(SUCRA) = 71.7), Triglyceride(TG)(SUCRA = 96.8), Low-Density Lipoprotein Cholesterol(LDL-C)(SUCRA = 86.1) in patients with NAFLD including triglycerides. Aerobic training is the best mode to improve ALT(SUCRA = 83.9) and High density lipoprotein cholesterol (HDL-C) (SUCRA = 72.3). Resistance training is the best mode to improve aspartate transaminase (AST) (SUCRA = 81.7). Taking various benefits into account, we believe that the best modality of exercise for NAFLD patients is aerobic training + resistance training. In our current network meta-analysis, these exercise methods have different effects on the six indicators of NAFLD, which provides some reference for further formulating exercise prescription for NAFLD patients.

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Section: Discussionsupporting

confidence: 93%

Effect of Different Exercise Modalities on Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-analysis

Peng,

Xue,

Zhang

et al. 2023

Preprint

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“…Previous large systematic reviews, including a recent Cochrane review and those with quantitative meta-analysis, have examined the individual components of the ACSM FITT exercise prescription, including frequency, intensity, time, and type. 47 , 57 , 107 , 130 Each has found significant heterogeneity owing to variation in the FITT principles. Across the primary literature, exercise frequency ranges from 3 to 7 days/wk; intensities that have been studied include low, moderate, moderate-vigorous, and vigorous.…”

Section: Considerations For Prescribing An Exercise Training Programmentioning

confidence: 99%

American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable report on physical activity and nonalcoholic fatty liver disease

Stine

Long

Corey

et al. 2023

Hepatology Communications

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Background and Aims: We present findings from the inaugural American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable, which was convened to evaluate the evidence for physical activity as a means of preventing or modifying the course of NAFLD. Approach and Results: A scoping review was conducted to map the scientific literature and identify key concepts, research gaps, and evidence available to inform clinical practice, policymaking, and research. The scientific evidence demonstrated regular physical activity is associated with decreased risk of NAFLD development. Low physical activity is associated with a greater risk for disease progression and extrahepatic cancer. During routine health care visits, all patients with NAFLD should be screened for and counseled about physical activity benefits, including reduction in liver fat and improvement in body composition, fitness, and quality of life. While most physical activity benefits occur without clinically significant weight loss, evidence remains limited regarding the association between physical activity and liver fibrosis. At least 150 min/wk of moderate or 75 min/wk of vigorous-intensity physical activity are recommended for all patients with NAFLD. If a formal exercise training program is prescribed, aerobic exercise with the addition of resistance training is preferred. Conclusions: The panel found consistent and compelling evidence that regular physical activity plays an important role in preventing NAFLD and improving intermediate clinical outcomes. Health care, fitness, and public health professionals are strongly encouraged to disseminate the information in this report. Future research should prioritize determining optimal strategies for promoting physical activity among individuals at risk and in those already diagnosed with NAFLD.

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“…Exercise interventions have been demonstrated to significantly improve the liver transaminases regardless of the age, although more profound benefits have been observed in younger adults[ 30 ]. Along with improvements in MAFLD, various exercise programs have also been associated with improvements in metabolic parameters such as plasma levels of glucose, insulin, HbA1c, LDL-C, triglycerides, and HOMA-IR[ 31 , 32 ].…”

Section: Management Approach To Mafldmentioning

confidence: 99%

Management of metabolic-associated fatty liver disease: The diabetology perspective

Jeeyavudeen¹,

Khan²,

Fouda³

et al. 2023

World J Gastroenterol

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The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists. Management of these individual disorders in a patient should be addressed wholistically using an appropriate multidisciplinary team approach involving both the specialists and, when necessary, liaising with dieticians and surgeons. This comprehensive review is to compile the current evidence from a diabetologist's perspective on MAFLD and T2DM and to suggest optimal management strategies.

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Intervention effects of four exercise modalities in nonalcoholic fatty liver disease：systematic review and Bayesian network meta-analysis

Abstract: Sensitivity analysis: Not applicable. A metaanalysis will not be performed. Language: English. Country(ies) involved: China.

Cited by 10 publications

References 0 publications

Effect of Different Exercise Modalities on Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-analysis

Effect of Different Exercise Modalities on Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-analysis

American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable report on physical activity and nonalcoholic fatty liver disease

Management of metabolic-associated fatty liver disease: The diabetology perspective

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