Intervenir précocement dans les stades débutants du trouble bipolaire : pourquoi, quand et comment

Pouchon, Arnaud; Fakra, Éric; Haesebaert, Frédéric; Legrand, Guillaume; Rigon, Maxence; Schmitt, Erica L.; Conus, Philippe; Bougerol, Thierry; Polosan, Mircea; Dondé, Clément

doi:10.1016/j.encep.2021.05.007

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…For UPD, antidepressants are used clinically to treat depressive symptoms and prevent their relapse. In the case of BPD, in addition to treating depressive symptoms, prevention of (hypo)manic episodes is also required and thus it is mainly treated with mood stabilizers and/or atypical antipsychotics 24 , 25 . BPD is often misdiagnosed as UPD, leading to incorrect treatment with unopposed antidepressants.…”

Section: Introductionmentioning

confidence: 99%

Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression

Zeng

Zhang

Xiang

et al. 2023

npj Mental Health Res

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There is a lack of objective features for the differential diagnosis of unipolar and bipolar depression, especially those that are readily available in practical settings. We investigated whether clinical features of disease course, biomarkers from complete blood count, and blood biochemical markers could accurately classify unipolar and bipolar depression using machine learning methods. This retrospective study included 1160 eligible patients (918 with unipolar depression and 242 with bipolar depression). Patient data were randomly split into training (85%) and open test (15%) sets 1000 times, and the average performance was reported. XGBoost achieved the optimal open-test performance using selected biomarkers and clinical features—AUC 0.889, sensitivity 0.831, specificity 0.839, and accuracy 0.863. The importance of features for differential diagnosis was measured using SHapley Additive exPlanations (SHAP) values. The most informative features include (1) clinical features of disease duration and age of onset, (2) biochemical markers of albumin, low density lipoprotein (LDL), and potassium, and (3) complete blood count-derived biomarkers of white blood cell count (WBC), platelet-to-lymphocyte ratio (PLR), and monocytes (MONO). Overall, onset features and hematologic biomarkers appear to be reliable information that can be readily obtained in clinical settings to facilitate the differential diagnosis of unipolar and bipolar depression.

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Section: Introductionmentioning

confidence: 99%

Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression

Zeng

Zhang

Xiang

et al. 2023

npj Mental Health Res

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“…The identification of youth at high risk of developing a psychotic disorder or other mental disorders is now an important objective in clinical practice and current research (Lee et al, 2014; McGorry et al, 2010; Pouchon et al, 2022). Over the past decades, the concept of “clinical high risk” for psychosis (CHR‐P, also referred to as “ultra high‐risk” or “at risk mental state”) has been introduced as an inclusive clinical construct that captures potentially prodromal symptoms for psychosis in young individuals (McGorry et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Detection of clinical high risk for psychosis in child and adolescent mental health services: Validation of the first step with the French versions of the Prodromal Questionnaire (fPQ‐16) and scale of Perceptual and Cognitive Aberrations (fPCA)

Spillebout

Pelluet

Bioulac

et al. 2023

Early Intervention Psych

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Aim To validate the French versions of the 16‐items Prodromal Questionnaire (PQ‐16) and the 9‐items scale of Perceptual and Cognitive Aberrations (PCA) to facilitate screening of psychosis risk in native French‐speaking young individuals referred to Child and Adolescent Mental Health Services. Method Participants (N = 87, age range 10—18 years) were diagnosed with a non‐psychotic disorder according to the Diagnostic and Statistical Manual of Mental Disorders. The French versions of the PQ‐16 and PCA were developed using a forward–backward translation procedure. Psychometric properties were tested including (i) internal validity with Pearson correlations and Cronbach's coefficients, and (ii) external validity by correlations with each other's. Results (i) Correlations between fPQ‐16 and fPCA total scores and individual items were mostly >.4. Cronbach's coefficients were .80 for the fPQ‐16 and .61 for the fPCA. (ii) The fPQ‐16 and fPCA total scores were significantly correlated with a large effect size (rs = 0.66). Conclusion The fPQ‐16 and the fPCA are psychometrically acceptable instruments for the screening of potential psychotic symptoms in French‐speaking children and young adolescents under 18 years old referred to Child and Adolescent Mental Health Services.

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Brain-derived neurotrophic factor and stress perception

Shkundin,

Wheeler,

Sinacore

et al. 2024

Personalized Medicine in Psychiatry

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Intervenir précocement dans les stades débutants du trouble bipolaire : pourquoi, quand et comment

Cited by 5 publications

References 78 publications

Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression

Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression

Detection of clinical high risk for psychosis in child and adolescent mental health services: Validation of the first step with the French versions of the Prodromal Questionnaire (fPQ‐16) and scale of Perceptual and Cognitive Aberrations (fPCA)

Brain-derived neurotrophic factor and stress perception

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