Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats

Jia, Dandan; Cai, Mengxin; Xi, Yue; Du, Shao Jun; Tian, Zhenjun

doi:10.1016/j.lfs.2017.12.009

Cited by 34 publications

(15 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study showed the effect on muscle expression of an IL-6-like cytokine, LIF, in rats undergoing myocardial infarction. In this model the myocardial infarction-associated muscle wasting was recovered upon interval exercise and LIF was upregulated as well in gastrocnemii (Jia et al, 2018). These results contrast with other reports of a pro-cachectic role of (tumor-derived) LIF in cancer-associated muscle wasting (Seto et al, 2015), so further studies are needed to dissect the signaling pathway activated by LIF in muscle fibers and verify whether endogenous expression of LIF is altered in muscles atrophying because of various conditions.…”

Section: Myokines Altered In Heart Failurementioning

confidence: 97%

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

Piccirillo

2019

Front. Physiol.

View full text Add to dashboard Cite

Skeletal muscle is a highly vascularized tissue that can secrete proteins called myokines. These muscle-secreted factors exert biological functions in muscle itself (autocrine effect) or on short- or long-distant organs (paracrine/endocrine effects) and control processes such as metabolism, angiogenesis, or inflammation. Widely differing diseases ranging from genetic myopathies to cancers are emerging as causing dysregulated secretion of myokines from skeletal muscles. Myokines are also involved in the control of muscle size and may be important to be restored to normal levels to alleviate muscle wasting in various conditions, such as cancer, untreated diabetes, chronic obstructive pulmonary disease, aging, or heart failure. Interestingly, many myokines are induced by exercise (muscle-derived exerkines) and some even by specific types of physical activity, but more studies are needed on this issue. Most exercise-induced myokines travel throughout the body by means of extracellular vesicles. Restoring myokines by physical activity may be added to the list of mechanisms by which exercise exerts preventative or curative effects against a large number of diseases, including the deleterious muscle wasting they may cause. Extending our understanding about which myokines could be usefully restored in certain diseases might help in prescribing more tailored exercise or myokine-based drugs.

show abstract

Section: Myokines Altered In Heart Failurementioning

confidence: 97%

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

Piccirillo

2019

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Based on data obtained from other clinical populations, HIIT cycling may provide a better stimulus for overcoming the knee OA related sarcopenic outcomes (i.e. loss in leg muscle mass, strength and function ( Alvarez et al, 2017 ; Jia et al, 2018 ), while still providing a range of cardiometabolic benefits than is currently achieved by MICT exercise mode such as cycling or aquatic exercise ( Francois & Little, 2015 ; Liou et al, 2016 ; Ramos et al, 2015 ; Shiraev & Barclay, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Is high-intensity interval cycling feasible and more beneficial than continuous cycling for knee osteoarthritic patients? Results of a randomised control feasibility trial

Keogh

Grigg

Vertullo

2018

PeerJ

View full text Add to dashboard Cite

BackgroundKnee osteoarthritis (OA) patients often suffer joint pain and stiffness, which contributes to negative changes in body composition, strength, physical performance (function), physical activity and health-related quality of life. To reduce these symptoms and side effects of knee OA, moderate-intensity continuous training (MICT) cycling is often recommended. While resistance training is considered the optimal form of training to improve sarcopenic outcomes, it imposes higher joint loads and requires supervision, either initially or continuously by trained exercise professionals. Therefore, this pilot study sought to gain some insight into the feasibility and potential benefits of high-intensity interval training (HIIT) cycling as an alternative exercise option to MICT cycling for individuals with knee OA.MethodsTwenty-seven middle-aged and older adults with knee OA were randomly allocated to either MICT or HIIT, with both programs involving four unsupervised home-based cycling sessions (∼25 min per session) each week for eight weeks. Feasibility was assessed by enrolment rate, withdrawal rate, exercise adherence and number of adverse effects. Efficacy was assessed by health-related quality of life (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne index), physical function (Timed Up and Go (TUG), Sit to Stand (STS) and preferred gait speed) and body composition (body mass, BMI, body fat percentage and muscle mass).ResultsTwenty-seven of the interested 50 potential participants (54%) enrolled in the study, with 17 of the 27 participants completing the trial (withdrawal rate of 37%); with the primary withdrawal reasons being unrelated injuries or illness or family related issues. Of the 17 participants who completed the trial, exercise adherence was very high (HIIT 94%; MICT 88%). While only three individuals (one in the MICT and two in the HIIT group) reported adverse events, a total of 28 adverse events were reported, with 24 of these attributed to one HIIT participant. Pre–post-test analyses indicated both groups significantly improved their WOMAC scores, with the HIIT group also significantly improving in the TUG and STS. The only significant between-group difference was observed in the TUG, whereby the HIIT group improved significantly more than the MICT group. No significant changes were observed in the Lequesne index, gait speed or body composition for either group.DiscussionAn unsupervised home-based HIIT cycle program appears somewhat feasible for middle-aged and older adults with knee OA and may produce similar improvements in health-related quality of life but greater improvements in physical function than MICT. These results need to be confirmed in larger randomised controlled trials to better elucidate the potential for HIIT to improve outcomes for those with knee OA. Additional research needs to identify and modify the potential barriers affecting the initiation and adherence to home-based HIIT cycling exercise programs by individuals with knee OA.

show abstract

“…Both FSS exposure and a microgravity environment can affect LIF expression levels. Previous reports showed the effects of LIF on muscle load and exercise, further influencing bone mineral mass (Rauch and Schoenau, 2001;Brotto and Bonewald, 2015;Jia et al, 2018). Liang et al (2011) found that continuous orthodontic forces promoted LIF/LIFR expression in the periodontal tissue.…”

Section: Discussionmentioning

confidence: 97%

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

Yang

et al. 2020

Front. Mol. Biosci.

View full text Add to dashboard Cite

PurposeBone remodeling is affected by mechanical stimulation. Osteocytes are the primary mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast activity, thus playing a key role in bone remodeling. Further, bone mass during exercise is also regulated by Leukemia inhibitory factor (LIF). This study aimed to investigate the role of LIF in the mechanical response of the bone, in vivo and in vitro, and to elucidate the mechanism by which osteocytes secrete LIF to regulate osteoblasts and osteoclasts.MethodsA tail-suspension (TS) mouse model was used in this study to mimic muscular disuse. ELISA and immunohistochemistry were performed to detect bone and serum LIF levels. Micro-computed tomography (CT) of the mouse femurs was performed to measure three-dimensional bone structure parameters. Fluid shear stress (FSS) and microgravity simulation experiments were performed to study mechanical stress-induced LIF secretion and its resultant effects. Bone marrow macrophages (BMMs) and bone mesenchymal stem cells (BMSCs) were cultured to induce in vitro osteoclastogenesis and osteogenesis, respectively.ResultsMicro-CT results showed that TS mice exhibited deteriorated bone microstructure and lower serum LIF expression. LIF secretion by osteocytes was promoted by FSS and was repressed in a microgravity environment. Further experiments showed that LIF could elevate the tartrate-resistant acid phosphatase activity in BMM-derived osteoclasts through the STAT3 signaling pathway. LIF also enhanced alkaline phosphatase staining and osteogenesis-related gene expression during the osteogenic differentiation of BMSCs.ConclusionMechanical loading affected LIF expression levels in osteocytes, thereby altering the balance between osteoclastogenesis and osteogenesis.

show abstract

Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats

Cited by 34 publications

References 44 publications

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

Is high-intensity interval cycling feasible and more beneficial than continuous cycling for knee osteoarthritic patients? Results of a randomised control feasibility trial

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

Contact Info

Product

Resources

About