2011
DOI: 10.1007/s00431-011-1480-z
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Interval between onset of symptoms and diagnosis of medulloblastoma in children: distribution and determinants in a population-based study

Abstract: Hospital-based studies have reported long delays in the diagnosis of paediatric brain tumours. Our objective was to describe the duration between onset of symptoms and diagnosis of medulloblastoma in children and study their clinical determinants in a population-based study. This retrospective cohort study included all paediatric medulloblastoma from a region of France from 1990 to 2005. The median interval from symptom onset until diagnosis for these 166 patients was 65 days and did not decrease during the st… Show more

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Cited by 43 publications
(63 citation statements)
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References 42 publications
(58 reference statements)
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“…3 This can lead to prediagnostic symptomatic intervals (PSI) ('diagnostic time lags') in the range of several weeks to months. [4][5][6][7][8][9][10][11] The assumption that a longer PSI may result in a more advanced disease stage and/or have an adverse impact on tumor control, survival and/or neurological/neuropsychological/quality of survival outcome may lead to selfreproaches from parents and physicians and can result in accusations of medical malpractice. [12][13][14] However, available information on the correctness of this assumption is insufficient, as studies on PSI in children with brain tumors suffer from low patient numbers, retrospective design, heterogeneity of patient, disease, and treatment characteristics, and lacking outcome data.…”
Section: -2mentioning
confidence: 99%
See 1 more Smart Citation
“…3 This can lead to prediagnostic symptomatic intervals (PSI) ('diagnostic time lags') in the range of several weeks to months. [4][5][6][7][8][9][10][11] The assumption that a longer PSI may result in a more advanced disease stage and/or have an adverse impact on tumor control, survival and/or neurological/neuropsychological/quality of survival outcome may lead to selfreproaches from parents and physicians and can result in accusations of medical malpractice. [12][13][14] However, available information on the correctness of this assumption is insufficient, as studies on PSI in children with brain tumors suffer from low patient numbers, retrospective design, heterogeneity of patient, disease, and treatment characteristics, and lacking outcome data.…”
Section: -2mentioning
confidence: 99%
“…[12][13][14] However, available information on the correctness of this assumption is insufficient, as studies on PSI in children with brain tumors suffer from low patient numbers, retrospective design, heterogeneity of patient, disease, and treatment characteristics, and lacking outcome data. [4][5][6][7][8][9][10][11][15][16][17][18][19][20][21][22][23][24] To study the association of the PSI with disease stage at diagnosis as well as tumor control and survival outcome, we analyzed prospectively collected data on 224 homogeneously treated patients. 3.…”
Section: -2mentioning
confidence: 99%
“…Accordingly, only the length of the prediagnostic symptomatic interval (PSI) can provide some indirect evidence regarding the kinetics of tumour growth: Not only are differences documented between different types of brain tumours, with malignant tumours (e.g. MBs) having shorter PSIs than low-grade tumours [4,10,12,17,19], but considerable variability is seen within the patient group with MB [2,8]: In a large prospective series, we found PSIs ranging from 0 to 24 months, with a median of 2 months. Interestingly, the group of patients with the longest PSIs had lower stage disease at diagnosis and a better overall survival probability than that with shorter PSIs [6].…”
Section: Discussionmentioning
confidence: 99%
“…A median delay of 2 months may be counted from first symptoms to diagnosis [22]. In infants, macrocrania, vomiting or psychomotor regression are the main symptoms.…”
Section: Clinical Diagnosis and Stagingmentioning
confidence: 99%