Interval Between Inoculations as a Factor in Interference between Neurotropic Viruses

Duffy, Carl E.; Morgan, Paul N.

doi:10.3181/00379727-84-20623

Cited by 8 publications

(5 citation statements)

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“…Our findings, therefore, do not agree with those of Kleinschmidt and Murphy (4), who observed significant statoloninduced protection against MM virus which persisted for at least 30 days. In earlier studies, Schlesinger et al (5, 6) and Duffy and Morgan (1) found that a single dose of a nonfatal encephalitis virus protected animals for 2 weeks against antigenically heterologous encephalitis viruses. Our failure to demonstrate an enhanced resistance beyond 5 days may be explained by the differences in the viral agents used for challenge.…”

Section: Discussionmentioning

confidence: 97%

Duration of Prophylactic Effect of Statolon Against Mengovirus in Mice

Schmidt¹,

Pindak²

1968

Applied Microbiology

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Section: Discussionmentioning

confidence: 97%

Duration of Prophylactic Effect of Statolon Against Mengovirus in Mice

Schmidt¹,

Pindak²

1968

Applied Microbiology

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“…In early investigations on viral interference, Schlesinger et al (14,15) and Duffy and Morgan (2) reported that a single inoculation in animals of a nonfatal encephalitis virus imparted protection for 2 weeks against antigenically heterologous encephalitis viruses. The duration of protection that is produced in the mouse by a single injection of statolon against a subsequent fatal MM virus inoculation was investigated.…”

Section: Duration Of Statolon Activity In Micementioning

confidence: 99%

Interferon induction with statolon in the intact animal.

Kleinschmidt¹,

Murphy²

1967

Bacteriological Reviews

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“…The antiviral action of interferon is intracellular and may relate to an inhibition of the functioning of the viral messenger RNA with the cells ribosomes. The duration of activation of the interferon system (interference) is from 1 to 3 wk during acute virus infections in vivo (11)(12)(13).…”

mentioning

confidence: 99%

The Defensive Role of the Interferon System

Baron

1970

The Journal of General Physiology

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The evidence relating the interferon system to the infectious process has been examined. The available evidence supports the view that the interferon system is an important component of the body's nonimmune defenses, which are probably the major causes of recovery from already established virus infections of body tissues. The interferon system can also serve to limit virus spread through the bloodstream. Factors which may influence the interferon system and thereby influence virus infection have been considered. Finally, evidence is presented which indicates that the interferon system is one of the determinants of virulence of certain viruses and is one of the determinants of some persistent virus infections.The discovery of interferons by Isaacs and Lindenmann (1) led, within a short time, to major revisions in concepts of cellular immunity and recovery of multicellular organisms from infection. The significance of the antiviral effect of the interferon system extends to virus infections of the acute, chronic, and oncogenic varieties. More recent evidence suggests that the interferon system may play a role during infection by Chlamydia and certain protozoal parasites. This section will consider the implications of the interferon system as a host defense during infection. Several reviews contain related information (2-9). A more detailed consideration of the various host defenses during viral infection will be published (10). COMPONENTS OF THE INTERFERON SYSTEMThe term "interferon system" is used because this anti-infectious mechanism is now thought to be divisible into several components. For the present purposes we will refer to interferon as a protein(s) which is produced or released by cells following viral infection and certain other stimuli. Available evidence suggests that interferon is not itself directly antiviral, but rather, it reacts with cells to induce the formation of a new intracellular substance which mediates the antiviral activity. This antiviral component of the interferon system may be a polypeptide or a protein.

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Interval Between Inoculations as a Factor in Interference between Neurotropic Viruses

Cited by 8 publications

References 0 publications

Duration of Prophylactic Effect of Statolon Against Mengovirus in Mice

Duration of Prophylactic Effect of Statolon Against Mengovirus in Mice

Interferon induction with statolon in the intact animal.

The Defensive Role of the Interferon System

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