Intertrial interval dependent effect of lateral hypothalamic stimulation on spontaneous alternation behavior in a T-maze

Durantou, F.; Cazala, Pierre; Jaffard, Robert

doi:10.1016/0031-9384(89)90264-3

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…This fits to the description made by Deacon (2006) for mice. We can also confirm that for long ITIs alternation drops to chance level (Deacon 2006; Durantou et al 1989): Comparing alternation proportions of individual trials for experiment 2 revealed less alternation behaviour during the first trial of each day. Thus, the last choice of the day before (with an ITI > 21 h) seems not to be relevant for the first choice.…”

Section: Discussionsupporting

confidence: 73%

“…However, regarding which ITIs support spontaneous alternation and which not, the literature is mixed. Durantou et al (1989) report high alternation rates for ITIs of 30 s in rats (Durantou et al 1989), whereas in the T-maze protocol for appetitive position discrimination for both rats and mice by Deacon 2006, it is stated that in general ITIs shorter than 10 min lead to spontaneous alternation. In the review of Dember and Fowler 1958 focusing on alternation in rats, it is described that spontaneous alternation was observed for ITIs shorter than 2 min but in some studies also up to 60 min.…”

Section: Discussionmentioning

confidence: 99%

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Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Habedank

Kahnau

Lewejohann

2020

Preprint

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In rodents, the T-maze test is commonly used to investigate spontaneous alternating behaviour but it can also be used to investigate memory, stimuli discrimination or preference between goods. However, especially regarding T-maze preference tests there is no recommended protocol and researchers frequently report reproduction difficulties of this test using mice.Here, we aimed to develop an efficient protocol with female C57BL/6J mice, conducting two preference tests with different design: In a first test, on two consecutive days with five trials, thirteen mice had to choose between two fluids. In a second preference test, on five consecutive days with two (week 1) or three (week 2) trials, twelve mice had to choose between one arm containing bedding mixed with millet and one containing only bedding. This test design resembled a simple learning test (learn where to find the rewarded and the unrewarded arm on the basis of spatial, olfactory and visual cues).In both experiments, mice took only a few seconds per trial to run the maze and make their choice. However, in both experiments mice failed to show any preference for one of the arms. Instead, they alternated choices. We therefore believe the T-maze test to be rather unsuitable to test preference or learning behaviour with C57BL/6J mice.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Habedank

Kahnau

Lewejohann

2020

Preprint

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“…The theory of alternation postulates the existence of a memory trace relative to the information (or events) received on the first trials (acquisition). De- layed spontaneous alternation tasks could account for short-term memory processes or declarative memory in mice, and any increase in delay between acquisition and retention trials leads to a rapid decay in alternation behavior (Durantou et al, 1989). In our experiment, short-term memory or retrieval deficits seem unlikely since mutants were comparable to controls at the 6-h retention delay.…”

Section: Discussionmentioning

confidence: 89%

Influence of dystrophin-gene mutation onmdx mouse behavior. I. Retention deficits at long delays in spontaneous alternation and bar-pressing tasks

et al. 1995

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X-linked Duchenne muscular dystrophy (DMD) is frequently associated with a nonprogressive, cognitive defect attributed to the absence of dystrophin in the brain of DMD patients. The mutant mdx mouse, lacking in 427-kDa dystrophin in both muscle and brain tissues, is considered to be a valuable model of human DMD. In the present study, we compared mdx and C57BL/10 control mice and showed that mdx mice had impaired retention in a T-maze, delayed spontaneous alternation task 24 h, but not 6 h, after acquisition. mdx mice were not impaired in acquisition of a bar-pressing task on 4 consecutive days but showed poor retention 22 days after the last training session. Mutants and controls showed similar behavioral responses in free exploration and light/dark choice situations and did not differ in spontaneous locomotor activity or motor coordination. Retention impairments at long delays in mdx mice suggest a role of dystrophin in long-term consolidation processes.

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“…Certainly, post-trial stimulation of lateral hypothalamic neurons has been found previously to facilitate learning of passive avoidance and appetitive t-maze tasks, suggesting an additional direct role in consolidation of learning processes (Huston and Mueller 1978;Durantou et al 1989), and electrical stimulation of this region has also been reported speciÞcally to elicit previously learned responses (Popova and Pavlova 1977).…”

Section: Introductionmentioning

confidence: 96%

Post-session sulpiride infusions within the perifornical region of the lateral hypothalamus enhance consolidation of associative learning

Phillips¹,

Morutto²

1998

Psychopharmacology

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Whilst neurons within the lateral hypothalamus are well known to be responsive to the presentation of previously learned associative stimuli, the consolidation of a Pavlovian association is thought to depend in large part upon other brain regions, including the amygdala. The present study addressed this assumption directly, by examining the effect of post-session infusions of sulpiride within the lateral hypothalamus upon the acquisition of a conditioned approach response in an appetitive differential conditioning task. Subjects were exposed to an initially neutral stimulus (CS+), which immediately preceded the availability of a 10% sucrose reward (US). A second, control stimulus (CS ) was also presented. but never in close temporal proximity to the US. The number and duration of alcove approaches were recorded. Immediately following each training session, subjects were infused bilaterally with sulpiride (0, 0.5, 5 microg) in the vicinity of the perifornical region of the lateral hypothalamus. Sulpiride dose-dependently enhanced the rate of acquisition of a conditioned approach response to presentation of the CS+, but was without affect upon approach behaviour during CS(-) or US presentations. Thus, 0.5 microg sulpiride facilitated at an early stage (session 2 onwards) the number of alcove approaches to the CS+, while 5 microg sulpiride enhanced to a greater extent the duration of conditioned approach, particularly during later sessions. A subsequent locomotor test using 0.5 mg/kg d-amphetamine indicated that repeated infusions of the higher dose sulpiride (5 microg), but not the lower dose (0.5 microg), resulted in behavioural sensitisation to administration of the psychomotor stimulant. Acquisition of a novel conditioned instrumental response was not affected by previous exposure to sulpiride. These data suggest that dopamine-sensitive neurons within the lateral hypothalamus may play a significant role in the acquisition of appetitive Pavlovian associations.

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Intertrial interval dependent effect of lateral hypothalamic stimulation on spontaneous alternation behavior in a T-maze

Cited by 9 publications

References 14 publications

Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Alternate without alternative: Neither preference nor simple learning behaviour shown by C57BL/6J mice in the T-maze

Influence of dystrophin-gene mutation onmdx mouse behavior. I. Retention deficits at long delays in spontaneous alternation and bar-pressing tasks

Post-session sulpiride infusions within the perifornical region of the lateral hypothalamus enhance consolidation of associative learning

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