The between-population genetic architecture for growth and maturation has not been examined in detail for many animal species despite its central importance in understanding hybrid fitness. We studied the genetic architecture of population divergence in: (i) maturation probabilities at the same age; (ii) size at age and growth, while accounting for maturity status and sex; and (iii) growth plasticity in response to environmental factors, using divergent wild and domesticated Atlantic salmon (Salmo salar). Our work examined two populations and their multigenerational hybrids in a common experimental arrangement in which salinity and quantity of suspended sediments were manipulated to mimic naturally occurring environmental variation. Average specific growth rates across environments differed among crosses, maturity groups, and cross-by-maturity groups, but a growth-rate reduction in the presence of suspended sediments was equal for all groups. Our results revealed both additive and nonadditive outbreeding effects for size at age and for growth rates that differed with life stage, as well as the presence of different sex-and size-specific maturation probabilities between populations. The major implication of our work is that estimates of the genetic architecture of growth and maturation can be biased if one does not simultaneously account for temporal changes in growth and for different maturation probabilities between populations. Namely, these correlated traits interact differently within each population and between sexes and among generations, due to nonadditive effects and a level of independence in the genetic control for traits. Our results emphasize the challenges to investigating and predicting phenotypic changes resulting from between-population outbreeding. G ROWTH rate, the increase in body size per unit time, can vary substantially within and among populations. It can be directly or indirectly linked to fitness through lifehistory traits such as age at maturity or fecundity (Roff 1992;Stearns 2000). Rapid growth can increase survival probability and enable early reproduction but is usually traded off against later maturity with a higher fecundity (Lester et al. 2004). Furthermore, plasticity in growth can serve as a buffer for responding to environmental variation (Wright 1932;Schlichting and Pigliucci 1998). Consequently, the relationship between growth rate and age at maturity within wild populations might be shaped by local adaptation (Law 1979) or by anthropogenic selection and exploitation (Hutchings and Fraser 2008;Enberg et al. 2012).Intentional or unintentional anthropogenic translocations increase outbreeding among formerly isolated populations and can result in genotypic and phenotypic changes in local populations that affect individual fitness (Rhymer and Simberloff 1996;Allendorf et al. 2001). A common example is the escape of domesticated aquaculture fish into environments inhabited by their wild counterparts (Naylor et al. 2005;Morris et al. 2008). As with many other livestock sp...