Interstudy variability in cardiac magnetic resonance imaging measurements of ventricular volume, mass, and ejection fraction in repaired tetralogy of fallot: A prospective observational study

Abstract

CMR measures of ventricular size and function have acceptable repeatability across serial examinations in patients with repaired TOF. Measurements of RV mass are subject to higher variability. For most parameters, agreement limits are wider when measurements are performed by multiple operators. These results will aid in the interpretation of study-to-study variations in the follow-up of individual patients and in designing future clinical trials.

Global and Regional Functional Assessment of Ischemic Heart Disease with Cardiac MR Imaging

“…3 In both studies, CMR examinations were performed between 15 and 60 minutes apart; a different technologist performed the second CMR examination in the study by Blalock and colleagues. 8 Across both studies, interstudy intraobserver and interobserver agreement was good for LVEF, LVEDV, and LVESV, with coefficients of variability that compared favorably with within-study interobserver values (see Table 2). …”

“…3,7,8 Chuang and colleagues 7 performed a subgroup analysis in 10 patients to assess the within-study interobserver and intraobserver variance of CMR-determined LVEF, LV end-diastolic volume (EDV), and LV end-systolic volume (ESV) ( Table 2). The subgroup comprised 8 patients A 74-year-old man with ischemic cardiomyopathy.…”

Cardiac magnetic resonance markers of progressive RV dilation and dysfunction after tetralogy of Fallot repair

“…These threshold values were selected based on published data from the core CMR laboratory on reproducibility of ventricular measurements in repaired TOF 12 13. Specifically, the selected cut-off values exceed two SDs of the interobserver and interstudy variability for each parameter.…”

Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease

“…Assessment of ventricular function is more straightforward for patients with systemic LVs than for those with systemic RVs, but the use of cardiac magnetic resonance imaging has improved the assessment of RV function. 12 In general, throughout this document, severe ventricular dysfunction is defined as an ejection fraction (EF) <40%, moderate dysfunction as EF 40% to 50%, and normal as EF >50%. It should be recognized that these definitions are somewhat arbitrary.…”