Interstitielle Photodynamische Lasertherapie zur Behandlung von Lebermetastasen: Erste Ergebnisse einer in vivo Phase I-Studie

Engelmann, K.; Mg, Mack; Eichler, Katrin; Straub, Roland; Zangos, Stephan; Vogl, Thomas

doi:10.1055/s-2003-39205

Cited by 13 publications

(3 citation statements)

References 15 publications

(18 reference statements)

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“…Interstitial laser therapy was also already used as a therapy for liver metastases in Western medicine. First results of a clinical phase I study were published already 10 years ago by a German research team [6]. The authors of that study stated that i.st.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Interstitial Laser Acupuncture Depends upon Dosage: Experimental Results from Electrocardiographic and Electrocorticographic Recordings

Litscher

Jing

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The purpose of this study was to evaluate the influence of the duration of interstitial laser acupuncture therapy effects on neurovegetative and neurobioelectrical parameters like heart rate (HR), heart rate variability (HRV), and electroencephalogram (EEG). We investigated 6 male Sprague-Dawley rats. They underwent 10 min, 20 min, and 30 min interstitial laser acupuncture (in randomized order, with a break of at least 30 min between the different measurement conditions) at the acupoint Neiguan. HR changed significantly only during 20 min red laser stimulation, whereas 10 and 30 min stimulation did not induce significant changes. HRV did not change significantly during any of the different durations; however, an increase was found during 20 min irradiation. Neither the LF/HF ratio of HRV nor the integrated EEG showed significant changes. In this study, it could be experimentally proved that some effects of laser acupuncture are time dependent, and therefore the dosage, as well known from theory, also depends on the time factor. We could especially demonstrate that different treatment times lead to different effects on neurovegetative and neurobioelectrical parameters. Further studies are needed to verify or refute these results.

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Section: Discussionmentioning

confidence: 99%

“…The authors of that study stated that i.st. laser therapy of liver malignancies is a minimally invasive procedure with little side effects which produces sharply defined, yet small volumes of necrosis [6]. …”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Interstitial Laser Acupuncture Depends upon Dosage: Experimental Results from Electrocardiographic and Electrocorticographic Recordings

Litscher

Jing

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Eine große Vielfalt unterschiedlicher Methoden zur Energiedeposition im Gewebe wurden entwickelt und getestet: die Radiofrequenzablation (RFA) [1 -2], die Laser-induzierte interstitielle Thermotherapie (LITT) [3], der fokussierte Ultraschall (High-Intensity Focused Ultrasound, HIFU) [4], die Mikrowellen- [5] und die Kryotherapie [6]. In den letzten 10 Jahren wurde die RF-Ablation vor allem zur Behandlung primärer und sekundärer Lebertumoren genutzt [7 -10].…”

Section: Einführungunclassified

Radiofrequenzablation des Nierenzellkarzinoms unter MR-Bildgebung: Erste Ergebnisse

Boss¹,

Clasen²,

Kuczyk³

et al. 2005

Fortschr Röntgenstr

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MALDI‐TOF mass spectrometric analysis for the characterization of the 5,10,15,20‐tetrakis‐ (m‐hydroxyphenyl)bacteriochlorin (m‐THPBC) photoproducts in biological environment

Lassalle¹,

Lourette²,

Maunit³

et al. 2005

J. Mass Spectrom.

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Photoproducts formation upon irradiation (739 nm) of 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (m-THPBC) in phosphate buffer saline (PBS) supplemented with human serum albumin (HSA) were studied by means of absorption spectroscopy and MALDI-TOF mass spectrometry. The experiments were performed with a freshly prepared PBS-HSA solution of m-THPBC and with a PBS-HSA m-THPBC solution incubated for 6 h at 37 degrees C. The incubation of m-THPBC solution leads to the dye monomerisation, whereas in the freshly prepared solution, m-THPBC is under an aggregated form. Regardless of the incubation condition, photobleaching experiments carried out by absorption spectroscopy demonstrate the degradation of the photosensitizer and its phototransformation in m-THPC. Moreover, m-THPC was the sole photoproduct detected using absorption spectroscopy. Together with a degradation of m-THPBC and formation of m-THPC, MALDI-TOF mass spectrometry evidenced several other photoinduced modifications. Photoproducts such as dihydroxy m-THPBC and dihydroxy m-THPC were detected in both conditions; however, the formation of hydroxylated photoproducts was significantly greater in incubated solution. In addition, small molecules arising from the degradation of the photosensitizer and identified as dipyrin derivatives and dipyrrolic synthon were observed.

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Interstitielle Photodynamische Lasertherapie zur Behandlung von Lebermetastasen: Erste Ergebnisse einer in vivo Phase I-Studie

Abstract: The photodynamic laser therapy of liver malignancies is a minimal invasive procedure with little side effects which produces sharply defined yet small volumes of necrosis.

Cited by 13 publications

References 15 publications

Effectiveness of Interstitial Laser Acupuncture Depends upon Dosage: Experimental Results from Electrocardiographic and Electrocorticographic Recordings

Effectiveness of Interstitial Laser Acupuncture Depends upon Dosage: Experimental Results from Electrocardiographic and Electrocorticographic Recordings

Radiofrequenzablation des Nierenzellkarzinoms unter MR-Bildgebung: Erste Ergebnisse

MALDI‐TOF mass spectrometric analysis for the characterization of the 5,10,15,20‐tetrakis‐ (m‐hydroxyphenyl)bacteriochlorin (m‐THPBC) photoproducts in biological environment

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