Interstitial single fraction brachytherapy for malignant pulmonary tumours

Rashid, Ali; Pinkawa, Michael; Haddad, Hathal; Hermani, Horst; Temming, Susanne; Schäfer, Andreas; Bischoff, Peter; Kovács, Attila

doi:10.1007/s00066-021-01758-5

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Therefore, the dose of irradiation is little and safe for organs such as esophagus, heart or spinal cord in LDR brachytherapy. Even in high-dose-rate endobronchial brachytherapy or interstitial brachytherapy, the dose exposed in spinal cord, heart and esophagus is safe ( 13 , 14 ), let alone LDR brachytherapy for our case. Spinal cord was contoured in our case, because it’s so crucial that any overdose could lead to irreversible injury.…”

Section: Discussionmentioning

confidence: 75%

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Ke¹,

Zeng²,

Chen³

et al. 2023

Front. Oncol.

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Adenoid cystic carcinoma (ACC) of central airway is very rare. More than half of ACCs are unresectable for tumor extension. There’s rare report on local ACCs only in central airway. We present a case of ACC in central airway who underwent an innovative brachytherapy. A 44-year-old woman was diagnosed with primary ACC in central airway without regional lymphadenopathy or metastatic disease. Stenosis was observed in lower trachea and both left and right main bronchi (stenosis in lumen ≥50%) with bronchoscopy. The tumor was unresectable due to local extension. A Y-shaped and stainless-steel stent loaded with radioactive 125I seeds was placed in the central airway using bronchoscope. The number and distribution of 125I seeds were planed using treatment planning system. The stent was removed three months later. The patient tolerated the procedure well. She was alive without relapse three years after removing the stent with 125I seeds. This case demonstrates the successful use of stent with radioactive 125I seeds for unresectable ACCs in central airway. In the procedure, the stent was placed with bronchoscope and under the vision from bronchoscope. This innovative brachytherapy is well-tolerated, safe, precise and individualized designed. The patient with unresectable ACCs could get a long-term relapse-free survival. Clinical trials could be taken to validate its effectiveness and tolerability in patients with ACCs of central airway.

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Section: Discussionmentioning

confidence: 75%

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Ke¹,

Zeng²,

Chen³

et al. 2023

Front. Oncol.

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“…Moreover, interstitial brachytherapy also has several advantages such as convenient operation, good tolerance, low cost, slight damage to normal tissue, and fewer side effects [ 18 ]. It is reported that the therapeutic effect of interstitial brachytherapy to increase radiotherapy dose can achieve a similar effect of radical surgery, considered as “proton therapy” for patients with a poor economic capacity [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats

Chen

Wang

et al. 2023

J Inflamm

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Background To compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brachytherapy and stereotactic radiotherapy (SBRT). Methods RILI rat model was established using interstitial brachytherapy and SBRT methods, respectively. CT scan was performed to analyze the lung volume and the CT value difference between the left and right lungs in rats. Then the lung tissues were analyzed through H&E staining, peripheral blood was extracted to detect the expression levels of serum inflammatory cytokines, pro-fibrotic cytokines, and fibrotic-inhibiting cytokines by ELISA. Results The difference between right and left lung CT values was significantly elevated in the SBRT group when compared with the control group and the interstitial brachytherapy group (P < 0.05). The IFN-γ expression in the interstitial brachytherapy group was significantly different from that in the SBRT group at week 1, 4, 8 and 16. Besides, the expressions of IL-2, IL-6 and IL-10 in SBRT group were significantly higher than that of interstitial brachytherapy group (P < 0.05). The TGF-β expression in interstitial brachytherapy group reached its peak with the increase of time from week 1 to week 16, and it was significantly lower than SBRT group (P < 0.05). The mortality rate in the SBRT group was 16.7%, which was significantly higher than that in the interstitial brachytherapy group. Conclusion The treatment method of interstitial brachytherapy is considered as an effective and safe tool by reducing the side effects of radiotherapy and increasing the radiation dose of radiotherapy.

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Advanced navigation technology enables endobronchial brachytherapy for peripheral lung cancer: An old technique plays a new role

Li,

Jiang,

Jiang

et al. 2024

Brachytherapy

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Interstitial single fraction brachytherapy for malignant pulmonary tumours

Cited by 3 publications

References 24 publications

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

Stent loaded with radioactive Iodine-125 seeds for adenoid cystic carcinoma of central airway: A case report of innovative brachytherapy

The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats

Advanced navigation technology enables endobronchial brachytherapy for peripheral lung cancer: An old technique plays a new role

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