Interstitial photodynamic therapy in a rat liver metastasis model

Efficacy of Direct Electrical Current Therapy and Laser-Induced Interstitial Thermotherapy in Local Treatment of Hepatic Colorectal Metastases: An Experimental Model in the Rat

“…To optimize the set-up for the interstitial laser coagulation, different study groups varied the laser power and the overall applied energy, used different fiber tips, multiple fibers, and tried to alter the position of the tip during therapy [18 -21]. In animal studies, complete tumor necrosis of colorectal metastases was achieved in 25% to 75% of cases [22,23]. Primary clinical studies described a complete response rate of 0% to 97% and a partial response rate of up to 87% after LITT of colorectal liver metastases [24,25].…”

Interstitial photodynamic therapy with the second-generation photosensitizer bacteriochlorin a in a rat model for liver metastases

“…This can be overcome by delivering light directly into the tumour -a treatment called interstitial therapy . The ability of interstitial photodynamic therapy (IPDT) to cause destruction of tumours within the liver has been demonstrated in animal studies, using HpD and Photofrin (Holt et al, 1985;van Hillegersberg et al, 1992). Although tumour destruction was accomplished, there was also considerable damage to surrounding liver tissue, and the amount of tissue that could be treated was limited.…”

Biodistribution of Photofrin II® and 5-Aminolevulinic Acid-Induced Protoporphyrin IX in Normal Rat Bladder and Bladder Tumor Models: Implications for Photodynamic Therapy

“…Photodynamic therapy (PDT)? is a promising cancer treatment for small, superficial tumors (1,2). As such it may be useful to treat dysplastic, premalignant lesions and carcinoma in situ (CIS) of the bladder that are not amenable to transurethral resection.…”

“…Experimental and preliminary clinical studies suggest several advantages using ALA-based PDT: (1) The ALA-induced PpIX is rapidly eliminated from the body if ALA is given systemically, and hence the risk of skin phototoxicity is limited t o 24 h. (2) Unlike PII, which accumulates more in the submucosal vascular stroma, ALA-induced PpIX is preferentially accumulated in the mucosa (epithelium) of hollow viscera and consequently, bladder muscle damage may be avoided.…”