Interstitial Lung Disease in Systemic Lupus Erythematosus

Abstract

Connective tissue disease (CTD) is one of the etiologies of known-cause interstitial lung disease (ILD) that is frequently found with systemic sclerosis, rheumatoid arthritis, mixed-CTD and Sjӧgren syndrome, but which occurs rarely in systemic lupus erythematosus (SLE) patients. A diagnosis of ILD in SLE can be challenging, as the physician should first exclude other pulmonary involvements, including airway disorders, pulmonary infection and vascular abnormality. The management of ILD in SLE and other CTDs patients includes corticosteroid and other immunosuppressive medications. Here we report on two ILD in SLE cases: in one case, ILD was the first sign of SLE; and in another, ILD appeared after the diagnosis of SLE had been established.

Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report

“…Anticoagulants for lupus are more frequently detected in men. 12 In 70% of cases, skin rashes and photosensitivity can be seen in SLE patients. The most common type, butterfly or malar rash, is less common in men.…”

“…To evaluate the safety and effectiveness of corticosteroids and immunosuppressant medications for the treatment of ILD owing to SLE. 11,12 More specifically, it is recommended to use azathioprine/MMF and corticosteroids as first-line treatment for mild and moderate forms; these medications can also be maintained as maintenance therapy. 11,13,14 Patients with increasing and severe disease courses linked with fibrotic CTD-related ILD should be carefully evaluated for lung transplantation and antibiotic therapies.…”