Interstitial lung disease in South Africans with systemic sclerosis

Ashmore, Philippa; Tikly, Mohammed; Wong, Michelle; Ickinger, Claudia

doi:10.1007/s00296-017-3893-0

Cited by 20 publications

(21 citation statements)

References 46 publications

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“…Information on silica exposure was not available in 92% of study subjects, but was reported in 141 patients [8%] [ 4 , 45 , 48 , 49 , 91 , 92 ] which were mostly miners. Only 5 patients [0.3%] were reported to be free of silica exposure [ 14 , 21 , 50 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…The presence or absence of telangiectasia was documented in 321 patients [17%] of all patients]); in whom telangiectasia were present in 73 patients [23%]. In the publication with the most representative data, telangiectasia were present in only 19 of 151 patients [13%] [ 49 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…307 patients [42%] had skin ulcers either at the time of inclusion in a study or during the follow-up observation. In 2 retrospective South African studies with greater detail, the frequencies of ever having had any ulceration were 71% (of 174 patients) and 44% (of 151 patients) [ 5 , 49 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…Spirometry results were reported in 184 of all SSc patients [ 6 - 8 , 10 , 13 , 14 , 17 , 19 , 24 , 26 , 27 , 29 , 38 , 39 , 41 , 45 , 47 - 49 , 85 ], either as percentage of predicted, or as a dichotomized result (normal/abnormal). 183 of these patients featured a reduced FVC.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

See 3 more Smart Citations

Systemic sclerosis in sub-Saharan Africa: a systematic review

Erzer¹,

Jaeger²,

Tikly³

et al. 2020

Pan Afr Med J

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Section: Current Status Of Knowledgementioning

confidence: 99%

Section: Current Status Of Knowledgementioning

confidence: 99%

Section: Current Status Of Knowledgementioning

confidence: 99%

Section: Current Status Of Knowledgementioning

confidence: 99%

See 2 more Smart Citations

Systemic sclerosis in sub-Saharan Africa: a systematic review

Erzer¹,

Jaeger²,

Tikly³

et al. 2020

Pan Afr Med J

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“…Anti-Ku patients with elevated creatine-kinase at baseline may develop ILD and a diagnosis of SSc and not myositis [ 29 ], mainly, but not exclusively, in patients with diffuse SSc and with a speckled ANA pattern. Conversely, the presence of anti-centromere was considered protective against ILD as already mentioned [ 30 ]. Additional autoAbs associated with the risk of ILD in SSc include anti-RP11 and anti-NOR90, in particular in male patients [ 31 ], while patients with isolated SSc-PH are less likely to have anti-Scl70/topoI autoAbs and they are more prone to be ACA positive.…”

Section: Autoabs Associated With Ild In Sscmentioning

confidence: 99%

Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies

Ceribelli

Isailovic

Santis

et al. 2020

Journal of Translational Autoimmunity

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Objectives Serum autoantibodies are pivotal for the early detection of systemic autoimmune rheumatic diseases such as Systemic Sclerosis (SSc) and Poly/Dermatomyositis (PM/DM), and in some cases are associated with organ complications such as interstitial lung disease (ILD). A paradigmatic example is provided by the autoantibody against the Eukaryotic Initiation Factor 2B (eIF2B) that has been recently detected in SSc. Methods Sera from 118 patients with SSc, 8 Poly/Dermatomyositis, 2 overlap SSc/Polymyositis, 4 undifferentiated connective tissue disease-UCTD and 3 healthy controls were tested first by indirect immunofluorescence for anti-nuclear antibodies-ANA pattern. Further, we employed prot ein-radioimmunoprecipitation (IP) and IP- Western Blot for the detection and confirmation of anti-eIF2B antibodies. Serum findings were further correlated with the clinical features of patients. Results We identified 3 SSc cases (2.5%) positive for anti-eIF2B antibodies while this autoantibody was not detected in control sera. Using protein-IP all three patients manifested the 38kD protein which is the antigenic target of anti-eIF2B antibodies, and this was associated with a cytoplasmic pattern at indirect immunofluorescence. The presence of anti-eIF2B was associated with ILD and a diffuse SSc variant, in one case in association with anti-Scl70/topoI. Conclusions Our data confirm that a small subgroup (2.5%) of patients with SSc have detectable anti-eIF2B with cytoplasmic-positive staining at immunofluorescence and this reactivity is associated with ILD.

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Causes and predictors of mortality in South Africans with systemic sclerosis

Dire

Ickinger

Tikly

2023

Rheumatology & Autoimmunity

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BackgroundThere is a dearth of mortality data on systemic sclerosis (SSc) in sub‐Saharan Africa. We undertook a retrospective study of causes and predictors of death in low‐income indigent South Africans with SSc.MethodsA retrospective records review of clinicodemographic, laboratory, and outcome data of SSc patients attending a state‐funded tertiary Rheumatology service in South Africa.ResultsMost of the 164 patients were Black (92.7%) and female (87.8%). The mean (SD) age at diagnosis and follow‐up duration were 42.6 (12.9) and 5.5 (5.6) years, respectively. The majority (75.6%) had diffuse cutaneous SSc (dcSSc); and digital pits/ulcers, interstitial lung disease (ILD), and pulmonary hypertension (PH) were documented in 73.6%, 55.0%, and 38.3%, respectively. There were 56 known deaths and an equal number of patients were lost to follow‐up. Deaths resulted from ILD complicated by PH (42.9%), infections (8.9%), cardiac disease (7.1%), and malignancies (3.6%). Estimated 5‐ and 10‐year survival rates for patients with known outcomes were 58% and 42%, respectively. Independent predictors of death were renal dysfunction and cor pulmonale.ConclusionMost patients in this study of South Africans had dcSSc and poor outcomes. Known deaths resulted from cardiorespiratory complications of ILD complicated by PH. Cor pulmonale and renal dysfunction were independent predictors of death.

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Interstitial lung disease in South Africans with systemic sclerosis

Abstract: BACKGROUND: Interstitial lung disease (ILD) is one of the leading causes of death

Cited by 20 publications

References 46 publications

Systemic sclerosis in sub-Saharan Africa: a systematic review

Systemic sclerosis in sub-Saharan Africa: a systematic review

Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies

Causes and predictors of mortality in South Africans with systemic sclerosis

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