Interstitial lung disease in children

Cazzato, Salvatore; Palmo, Emanuela di; Ragazzo, Vincenzo; Ghione, S

doi:10.1016/j.earlhumdev.2013.07.021

Cited by 19 publications

(27 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14,15 NECH arising in interstitial lung disease has primarily been reported in the paediatric population, and is part of the diagnostic criteria for neuroendocrine cell hyperplasia of infancy (NECHI). [16][17][18][19][20][21] In adults, a study by Wilson et al compared lungs with interstitial pneumonitis at necropsy, approximately half of which demonstrated frank honeycombing, to controls without pulmonary disease. Pulmonary neuroendocrine cells were found to be decreased in early fibrosis, and absent in areas of honeycombing, despite the fact that all cases contained numerous strips of well preserved epithelium.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema

2018

View full text Add to dashboard Cite

Using recently proposed pathological criteria, we determined the incidence of neuroendocrine cell proliferation in a series of explants with lung disease. Cases were defined as NECH (3 bronchioles with 5 endocrine cells), borderline diffuse neuroendocrine cell hyperplasia (DPNECH) (1-3 tumourlets with or without NECH), and DPNECH (3 tumourlets with NECH). Endocrine cells were identified by immunohistochemical staining for synaptophysin. There were 65 explants with interstitial lung disease (57 with non-sarcoid fibrotic lung disease, 8 with sarcoidosis), and 21 with centrilobular emphysema. Over one-third of all explant cases demonstrated histological criteria for NECH. There were three cases of DPNECH in the non-sarcoid fibrotic lung disease group (5%) and 20 cases of NECH (35%). The emphysema group had one case of DPNECH (5%), two cases of borderline DPNECH (10%), and seven cases with NECH (33%). The sarcoidosis group had two cases of DPNECH (25%) and three cases of NECH (38%). NECH is common in interstitial lung disease and emphysema. These results suggest that fibrotic lung disease is a predisposing factor for neuroendocrine cell proliferation, in addition to the known risk of epithelial neoplasms.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema

2018

View full text Add to dashboard Cite

show abstract

“…The understanding of the pathogenesis and diagnosis is due to advances in genetics. Some respiratory diseases in infants (surfactant or some diffuse lung developmental disorders) have a genetic basis (Cazzato et al 2013). The applications of HRCT are less developed.…”

Section: Bronchiolitis Obliterans Organizing Pneumonia: Organizing Pnmentioning

confidence: 99%

High-Resolution CT of the Lung in Children: Clinical Applications

Pointe

2014

Pediatric Chest Imaging

View full text Add to dashboard Cite

“… Impaired alveolar growth during gestation or early after birth is a common cause of chILD in premature infants. 5 Congenital alveolar dysplasia is a rare abnormality of lung development in which the lungs present incomplete alveolization despite term gestation. It is considered to be a severe form of lung hypoplasia in which the growth is stopped at the saccular stage of development.…”

Section: Classification Of Ildmentioning

confidence: 99%

“… 4 The chILD syndrome requires the presence of three of the following criteria in the absence of known primary disorders: (1) respiratory symptoms (cough, difficult breathing, or exercise intolerance), (2) respiratory signs (tachypnea, retractions, crackles, digital clubbing, failure to thrive, or respiratory failure), (3) hypoxemia, and (4) diffuse chest infiltrates on chest X-ray (CXR) or computed tomography (CT) scan. 2 , 5 There is an increasing number of reports concerning chILD, especially because of advances in genetic testing methods, but many points still remain unclear. Here, we review the following clinical features of chILD: epidemiology, classification, genetic aspects, diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Interstitial Lung Disease in Childhood: Clinical and Genetic Aspects

Kitazawa

Kure

2015

Clin Med Insights Circ Respir Pulm Med

View full text Add to dashboard Cite

Interstitial lung disease (ILD) in childhood is a heterogeneous group of rare pulmonary conditions presenting chronic respiratory disorders. Many clinical features of ILD still remain unclear, making the treatment strategies mainly investigative. Guidelines may provide physicians with an overview on the diagnosis and therapeutic directions. However, the criteria used in different clinical studies for the classification and diagnosis of ILDs are not always the same, making the development of guidelines difficult. Advances in genetic testing have thrown light on some etiologies of ILD, which were formerly classified as ILDs of unknown origins. The need of genetic testing for unexplained ILD is growing, and new classification criteria based on the etiology should be adopted to better understand the disease. The purpose of this review is to give an overview of the clinical and genetic aspects of ILD in children.

show abstract

Interstitial lung disease in children

Cited by 19 publications

References 70 publications

Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema

Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema

High-Resolution CT of the Lung in Children: Clinical Applications

Interstitial Lung Disease in Childhood: Clinical and Genetic Aspects

Contact Info

Product

Resources

About