Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

Cottin, Vincent; Thivolet‐Béjui, F.; Reynaud‐Gaubert, Martine; Cadranel, Jacques; Delaval, P.; Ternamian, P.-J.; Cordier, J.-F.

doi:10.1183/09031936.03.00026703

Cited by 239 publications

(211 citation statements)

References 28 publications

(43 reference statements)

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“…Regarding the anti-Jo-1 antibody, only one patient with chronic ILD-ADM had this antibody among the present ILD-ADM study. To date, several studies have reported a low incidence of anti-Jo-1 antibody in ILD-ADM patients [11][12][13][17][18][19]. The current results were consistent with those studies.…”

Section: Discussionsupporting

confidence: 83%

“…These data suggest that chronic ILD is unlikely to pre-exist in the study patients with acute/subacute ILD. Taken together, these results may account for the contradictory data previously reported in the prognosis of ILD-ADM. Namely, the fatal progressive ILD-ADM described is likely to correspond to the acute/subacute ILD-ADM in the present study, while the ILD-ADM with a favourable prognosis reported by COTTIN et al [13] may be equivalent to chronic ILD-ADM. Although ethnic differences may affect the clinical manifestations of ILD-ADM, it should be noted that ILD-ADM has these two different forms.…”

Section: Discussioncontrasting

confidence: 39%

“…These patients were often resistant to intensive therapy, such as highdose corticosteroids plus immunosuppressive agents, resulting in fatal respiratory failure. In contrast, a recent report from Europe emphasised a favourable prognosis of ILD associated with ADM (ILD-ADM) among ILD associated with ADM, DM, and polymyositis (PM) [13]. As ILD-ADM is a rare condition, its characteristics have not been fully clarified.…”

mentioning

confidence: 72%

“…Previous studies, mainly from Asia, have demonstrated that ILD-ADM generally runs an aggressive course, leading to fatal respiratory failure [7][8][9][10][11][12]. In contrast, COTTIN et al [13] recently described a benign form of ILD-ADM. They reported three patients with chronic ILD-ADM, and corticosteroids alone achieved a favourable response in two.…”

Section: Discussionmentioning

confidence: 97%

“…As ADM is a rare disease, previous studies of ILD-ADM included only one, or a few patients [7][8][9][10][11][12][13]. The present study investigated the highest number of patients with ILD-ADM so far.…”

Section: Discussionmentioning

confidence: 99%

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Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

European Respiratory Journal

149

116

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The aim of the present study was to clarify the clinical characteristics and prognosis of patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM).The study consisted of 14 consecutive patients with ILD-ADM. Patients were classified into two categories, acute/subacute and chronic forms, according to the clinical presentation of ILD. The clinical features, responsiveness to therapy, and prognosis between the two forms were compared.Nine ILD-ADM patients were categorised as the acute/subacute form, and five as the chronic form. Arterial oxygen tension was significantly lower in the acute/subacute ILD than chronic ILD patients. On high-resolution computed tomography, ground-glass opacities were frequently found in the two forms, but consolidation was more common in acute/subacute ILD than chronic ILD. Bronchoalveolar lavage analysis showed higher numbers of total cells and lymphocytes in acute/subacute ILD than chronic ILD. Histologically, the most common finding was nonspecific interstitial pneumonia in the two forms, while diffuse alveolar damage was only found in acute/ subacute ILD. Acute/subacute ILD was generally resistant to therapy, while chronic ILD responded well. Notably, the mortality of acute/subacute ILD was much higher than that of chronic ILD (67 versus 0%, respectively).In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses.

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Section: Discussionsupporting

confidence: 83%

Section: Discussioncontrasting

confidence: 39%

mentioning

confidence: 72%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

European Respiratory Journal

149

116

View full text Add to dashboard Cite

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Interstitial Lung Disease in Classic and Skin-Predominant Dermatomyositis

Morganroth

Kreider²,

Okawa³

et al. 2010

Arch Dermatol

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Interstitial Lung Disease in Anti–Jo‐1 Patients With Antisynthetase Syndrome

Marie

Josse

Hatron

et al. 2013

Arthritis Care & Research

124

106

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Objective. To assess the outcome of interstitial lung disease (ILD) in anti-Jo-1 patients with antisynthetase syndrome, determine predictive variables of ILD deterioration in these patients, and compare features of anti-Jo-1 patients with and without ILD. Methods. Ninety-one anti-Jo-1 patients were identified by medical records search in 4 medical centers. All of these patients had undergone pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) scans. Results. Sixty-six patients (72.5%) had ILD. Patients could be divided into 3 groups according to their presenting lung manifestations: acute onset of lung disease (n ‫؍‬ 12), progressive onset of lung signs (n ‫؍‬ 35), and asymptomatic patients exhibiting abnormalities consistent with ILD on PFTs and HRCT scans (n ‫؍‬ 19). Sixteen patients had resolution of ILD; 39 and 11 patients experienced improvement and deterioration of ILD, respectively. ILD led to decreased functional status, since 29.8% of patients exhibited a marked reduction of activities due to ILD and 13.6% had respiratory insufficiency requiring oxygen therapy; 5 of 6 patients died due to ILD complications. Predictive parameters of ILD deterioration were HRCT scan pattern of usual interstitial pneumonia, respiratory muscle involvement, and age >55 years. Furthermore, anti-Jo-1 patients with ILD, compared with those without, more frequently exhibited mechanic's hands and lower creatine kinase levels. Conclusion. Our findings confirm that ILD is a frequent complication in anti-Jo-1 patients, resulting in high morbidity. We suggest that patients with predictive factors of ILD deterioration may require more aggressive therapy. Finally, anti-Jo-1 patients with ILD, compared with those without, may exhibit a particular clinical phenotype.

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Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

Cited by 239 publications

References 28 publications

Interstitial lung diseases associated with amyopathic dermatomyositis

Interstitial lung diseases associated with amyopathic dermatomyositis

Interstitial Lung Disease in Classic and Skin-Predominant Dermatomyositis

Interstitial Lung Disease in Anti–Jo‐1 Patients With Antisynthetase Syndrome

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