Interstitial lung disease associated with trastuzumab monotherapy: A report of 3 cases

Sugaya, Akinori; Ishiguro, Shingo; Mitsuhashi, Shoichi; Abe, Masahiro; Hashimoto, Ikuta; Kaburagi, Takayuki; Kojima, Hiroshi

doi:10.3892/mco.2016.1113

Cited by 23 publications

(19 citation statements)

References 13 publications

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“…cTnI and LDH are considered reliable markers of cardiotoxicity and are as such used in monitoring drug-induced-cardiotoxicities including TZM [ 47 – 52 ]. The fact that the serum levels of cTn I and LDH were significantly elevated following repeated administration for 7 days is a strong indication that TZM -induced cardiac damage was reliably established and in consonance with reports of other studies [ 49 , 51 , 53 ]. However, repeated oral pretreatments with vitamin C, CVE , and IGE profoundly attenuated elevations in serum levels of these cardiac markers, thus, indicating the potential therapeutic role of these agents in mitigating the deleterious effects of TZM on the integrity cardiac myocytes.…”

Section: Discussionsupporting

confidence: 88%

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

Olorundare

Adeneye

Akinsola

et al. 2020

Oxidative Medicine and Cellular Longevity

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Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was designed at investigating the protective potential and mechanism(s) of CVE and IGE in TZM-induced cardiotoxicity utilizing cardiac enzyme and oxidative stress markers and histopathological endpoints. 400 mg/kg/day CVE and IGE dissolved in 5% DMSO in sterile water were investigated in Wistar rats injected with 2.25 mg/kg/day/i.p. route of TZM for 7 days, using serum cTnI and LDH, complete lipid profile, cardiac tissue oxidative stress markers assays, and histopathological examination of TZM-intoxicated heart tissue. Results showed that 400 mg/kg/day CVE and IGE profoundly attenuated increases in the serum cTnI and LDH levels but caused no significant alterations in the serum lipids and weight gain pattern in the treated rats. CVE and IGE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving TZM-associated cardiac histological lesions. These results suggest that CVE and IGE could be mediating its cardioprotection via antioxidant, free radical scavenging, and antithrombotic mechanisms, thus, highlighting the therapeutic potentials of CVE and IGE in the management of TZM-mediated cardiotoxicity.

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Section: Discussionsupporting

confidence: 88%

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

Olorundare

Adeneye

Akinsola

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…[9][10][11] In addition, in some of the cases, IP was experienced under radiotherapy. 12 It is sometimes difficult to conclude an association between drugs and complications. In our case, the patient had also been treated with trastuzumab/paclitaxel regimen.…”

Section: Discussionmentioning

confidence: 99%

“…The cases in literature usually were managed with steroid therapy and in most of the cases, patients gradually improved. 9,[11][12][13] However, rarely the scenario could be fatal.…”

Section: Discussionmentioning

confidence: 99%

Interstitial pneumonitis associated with trastuzumab emtansine

Alkan¹

2018

J Oncol Pharm Pract

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Trastuzumab emtansine is an antibody–drug conjugate that is effective in human epidermal growth factor receptor-2 expressing advanced breast cancer. Trastuzumab emtansine is generally well tolerated and grade 3–4 toxicities are rare. Pulmonary complications were rarely reported. Here we present a patient presenting with dyspnea after trastuzumab emtansine therapy and treated with a diagnosis of interstitial pneumonitis.

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“…1 With regards to breast cancer, there is an association between OP and specific disease-active therapies such as radiotherapy [2][3][4] and pharmacological agents. [5][6][7] In the case presented here, there was no history of exposure to these agents, and there was a long latency between initial malignant diagnosis and this presentation. Although there was a high clinical suspicion of recurrent malignancy, tissue obtained at VATS showed no evidence of malignancy and this incorrectly led the clinical team to not proceed with disease-specific therapies.…”

Section: Discussionmentioning

confidence: 76%

Breast cancer and organising pneumonia: the importance of correlating the pathological findings with the clinical and radiological picture

Griffiths¹,

Doran

Fullerton

2018

BMJ Case Reports

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This case describes a female patient with a history of breast cancer who presented with a persistent cough and weight loss after a 17-year disease-free period. Radiologically there were new bilateral intrapulmonary nodules and areas of consolidation with a broad differential diagnosis. Brushings gained via bronchoscopy were suggestive of malignancy, but subsequent video-assisted thoracoscopic surgery wedge resection demonstrated organising pneumonia (OP) with no evidence of malignancy. Diagnostic uncertainty remained after this, and after a period of observation, there was evidence of disease progression. Further tissue was obtained for cytological and histological assessment which provided conclusive evidence of metastatic breast cancer. In this case, OP was secondary to proximal bronchial obstruction due to metastatic infiltration, of which there are no reported similar cases in the current literature. We discuss the importance of differentiating secondary OP from cryptogenic OP.

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Interstitial lung disease associated with trastuzumab monotherapy: A report of 3 cases

Cited by 23 publications

References 13 publications

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

Interstitial pneumonitis associated with trastuzumab emtansine

Breast cancer and organising pneumonia: the importance of correlating the pathological findings with the clinical and radiological picture

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