Interstitial lung disease and diabetes

Rajasurya, Venkat; Gunasekaran, Kulothungan; Surani, Salim

doi:10.4239/wjd.v11.i8.351

Cited by 41 publications

(30 citation statements)

References 39 publications

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“…This group of patients is at a higher risk of infections given their immunosuppressed status due to concurrent or sequential chemotherapy and immunotherapy. Other differences include organizing pneumonia, drug-induced pneumonitis (immune checkpoint inhibitor pneumonitis), e-cigarette or vaping-use associated lung injury (EVALI), thromboembolic disease (SARS-CoV-2 infection also increases the risk of venous thromboembolism), interstitial lung disease, heart failure, lymphangitic carcinomatosis, and progression of malignancy [ 66 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ].…”

Section: Diagnosis Of Radiation Pneumonitismentioning

confidence: 99%

Radiation-Induced Lung Injury—Current Perspectives and Management

Rahi

Parekh

Pednekar

et al. 2021

Clinics and Practice

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Radiotherapy plays an important role in the treatment of localized primary malignancies involving the chest wall or intrathoracic malignancies. Secondary effects of radiotherapy on the lung result in radiation-induced lung disease. The phases of lung injury from radiation range from acute pneumonitis to chronic pulmonary fibrosis. Radiation pneumonitis is a clinical diagnosis based on the history of radiation, imaging findings, and the presence of classic symptoms after exclusion of infection, pulmonary embolism, heart failure, drug-induced pneumonitis, and progression of the primary tumor. Computed tomography (CT) is the preferred imaging modality as it provides a better picture of parenchymal changes. Lung biopsy is rarely required for the diagnosis. Treatment is necessary only for symptomatic patients. Mild symptoms can be treated with inhaled steroids while subacute to moderate symptoms with impaired lung function require oral corticosteroids. Patients who do not tolerate or are refractory to steroids can be considered for treatment with immunosuppressive agents such as azathioprine and cyclosporine. Improvements in radiation technique, as well as early diagnosis and appropriate treatment with high-dose steroids, will lead to lower rates of pneumonitis and an overall good prognosis.

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Section: Diagnosis Of Radiation Pneumonitismentioning

confidence: 99%

Radiation-Induced Lung Injury—Current Perspectives and Management

Rahi

Parekh

Pednekar

et al. 2021

Clinics and Practice

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“…In a study on the effects of diabetes on lung function, two groups of diabetic and non-diabetic overweight patients were examined. According to studies, all lung capacities (FVC, FEV1, DLCO, TLC) of patients with diabetes were lower than those of non-diabetic patients [29,30]. In a study to evaluate the histopathological changes in the lungs of diabetic rats, changes in lung tissue were investigated in two groups: the group with diabetes and the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Lung tissue is highly prone to damage and microvascular complications in diabetes because of its large vascular extent and abundant connective tissue [5]. Decreased lung function in people with diabetes is directly related to blood glucose levels, duration of diabetes, and severity of nonsmoking disease and obesity [6].…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and its Effects on MicroRNA-155 and MicroRNA-133a Expression in Lung Tissue of Male Rats

Khezri

Rahbarghazi‬

Ahmadi

et al. 2021

Preprint

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Background: The presence of an extensive vascular extent and large amounts of collagen and elastin in lung tissue make the lung parenchyma vulnerable to damage in diabetes. However, there are few studies on the pathophysiological effects of diabetes on lung tissue. In this study, we investigated the effects of type 2 diabetes on lung tissue pathology and the expression of miRNA-155 and miRNA-133a in lung tissue of male rats.Methods: In this study, 14 male rats were divided into a control group and a group with diabetes. The group with diabetes received a high-fat diet and a single dose of streptozotocin for one month. After induction of T2D, the rats received a normal diet for the next four weeks. At week 8, the rats were euthanized, and lung tissue was collected to measure microRNAs and examine tissue changes.Results: When lung tissue sections from diabetic rats were examined, the normal structure of the alveoli and alveolar sacs and bronchioles was disturbed. The thickness of interalveolar septa was increased due to the infiltration of inflammatory cells. The extensive alveolar collapse was the main cause of lung tissue structure disruption, and the accumulation of inflammatory cells and exudate secretions resulted in an interstitial pneumonia-like appearance. The expression of miRNA-155 was increased, and the expression of miRNA-133a was decreased in the lungs of diabetic rats compared with control rats.Conclusion: We found significant changes in the lung tissue of diabetic rats. By studying changes in the expression of microRNAs in diabetes, they can be a diagnostic and therapeutic biomarker in the lungs of patients with diabetes.

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“…This chronic systemic inflammation forms the most common denominator for COPD and DM. Several studies have shown that diabetes has a significant implication on the respiratory condition, including COPD, obstructive sleep apnea, and interstitial lung disease [ 10 , 11 , 12 ]. Diabetes mellitus (DM) in COPD patients was found to affect their lung function and, in turn, their prognosis [ 13 , 14 ], but their impact on COPD hospitalizations in terms of pneumonia, acute respiratory failure, stroke, acute kidney injury, and inhospital mortality has not been studied.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Diabetes Mellitus in Patients with Chronic Obstructive Pulmonary Disease (COPD) Hospitalization

Gunasekaran

Murthi

Elango

et al. 2021

JCM

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(1) Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Diabetes mellitus (DM) has been shown to have adverse inflammatory effects on lung anatomy and physiology. We investigated the impact of DM on COPD patient outcomes during inpatient hospitalization. (2) Methods: We conducted a retrospective analysis using the Nationwide Inpatient Sample (NIS) over the years 2002–2014. Three groups, COPD without diabetes, COPD with diabetes but no complication, and COPD with DM and complication, were analyzed. (3) Results: A total of 7,498,577 were COPD hospitalization; of those, 1,799,637 had DM without complications, and 483,467 had DM with complications. After adjusting for clinical, demographic, and comorbidities, the odds of increased LOS in the COPD/DM with complication were 1.37 (confidence interval (CI): 1.326–1.368), and those of DM without complication were 1.061 (1.052–1.070) when compared with COPD alone. The odds of pneumonia, respiratory failure, stroke, and acute kidney injury were also higher in COPD hospitalizations with DM. Both DM with complication (odds ratio (OR): 0.751 (CI 0.727–0.777)) and DM without complication (OR: 0.635 (CI: 0.596–0.675)) have lesser odds of mortality during hospitalization than with COPD alone. (4) Conclusions: There is a considerable inpatient burden among COPD patients with DM in the United States.

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Interstitial lung disease and diabetes

Cited by 41 publications

References 39 publications

Radiation-Induced Lung Injury—Current Perspectives and Management

Radiation-Induced Lung Injury—Current Perspectives and Management

Type 2 Diabetes and its Effects on MicroRNA-155 and MicroRNA-133a Expression in Lung Tissue of Male Rats

The Impact of Diabetes Mellitus in Patients with Chronic Obstructive Pulmonary Disease (COPD) Hospitalization

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