Interstitial Laser Ablation of the Kidney: Acute and Chronic Porcine Study Using New-Generation Diffuser Tip Fiber

LaGrange, Chad A.; Gerber, Eric; Garrett, Jenne E.; Lele, Subodh M.

doi:10.1089/end.2007.0004

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Cylindrical light diffusers made of glass are available in the market to obtain an uniform light distribution in particular in photodynamic therapy [1], [2], [3], interstitial photocoagulation [4], [5], interstitial hyperthermia [6], [7], and interstitial laser ablation [8]. Since these glass diffusers are expensive, these glass diffusers cannot be used as disposable use.…”

Section: Introductionmentioning

confidence: 99%

A low cost light diffuser made of metal coil

Nozomi

Arai

2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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We proposed a low cost flexible light diffuser made of metal coil to obtain an appropriate light dose against certain laser therapies in narrow bending organs. We investigated experimentally the diffusion light dose of prototype coils made of stainless steel (sus304). We measured the diffusion light intensity of the prototype coils along the irradiation direction and the circumferential direction with the various pitch distances of the prototype coils and numerical aperture (NA) of laser light beam as the characteristic parameters of the light diffusion. We measured the temperature elevation of the prototype coils to study the waste energy of these prototype coils. The FWHM on the light intensity along the prototype coils marked up to 12.8mm with the constant pitch distance of 0.09 mm and the fiber output light NA of 0.038. The FWHM on the light intensity was improved to 13.7 mm with the composite pitch distance coils of which the pitch distances were 0.09 mm in the proximate and 0.18 mm in the distal. Since the efficiency of the diffusion irradiation against the fiber output was typically 7.7% in the prototype coils of which the surface reflectance was 50%, approximately 90% of the laser light energy was transferred to the temperature elevation. We estimated the practical diffusion efficiency around 75% using the high reflection of the prototype coils surface up to 90%.

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Section: Introductionmentioning

confidence: 99%

A low cost light diffuser made of metal coil

Nozomi

Arai

2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Instrumentation and Technique

Venkatesh

Bylund

2013

Percutaneous Renal Surgery

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Ablative therapies for small renal tumours

et al. 2013

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Improvements in imaging technology have resulted in an increase in detection of small renal masses (SRMs). Minimally invasive ablation modalities, including cryoablation, radiofrequencey ablation, microwave ablation and irreversible electroporation, are currently being used to treat SRMs in select groups of patients. Cryoablation and radiofrequency ablation have been extensively studied. Presently, cryoablation is gaining popularity because the resulting ice ball can be visualized easily using ultrasonography. Tumour size and location are strong predictors of outcome of radiofrequency ablation. One of the main benefits of microwave ablation is that microwaves can propagate through all types of tissue, including desiccated and charred tissue, as well as water vapour, which might be formed during the ablation. Irreversible electroporation has been shown in animal studies to affect only the cell membrane of undesirable target tissues and to spare adjacent structures; however, clinical studies that depict the efficacy and safety of this treatment modality in humans are still sparse. As more experience is gained in the future, ablation modalities might be utilized in all patients with tumours <4 cm in diameter, rather than just as an alternative treatment for high-risk surgical patients.

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Interstitial Laser Ablation of the Kidney: Acute and Chronic Porcine Study Using New-Generation Diffuser Tip Fiber

Abstract: Interstitial laser ablation of the kidney with a diffuser tip fiber produces adequate cell death but small lesions. Further studies with multiple fibers or active monitoring and repositioning of the fiber to produce larger lesions are necessary.

Cited by 3 publications

References 16 publications

A low cost light diffuser made of metal coil

A low cost light diffuser made of metal coil

Instrumentation and Technique

Ablative therapies for small renal tumours

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