Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures

BACKGROUND Accurate stereotactic biopsies of brain tumors are imperative for diagnosis and tailoring of the therapy. Repetitive needle insertions enhance risks of brain lesioning, hemorrhage, and complications due to prolonged procedure. OBJECTIVE To investigate clinical benefits of a combined 5-aminolaevulinic acid (5-ALA) fluorescence and laser Doppler flowmetry system for the detection of malignant brain tumor and blood vessels in stereotactic biopsies. METHODS Planning of targets and trajectories was followed by optical measurements in 20 patients, using the Leksell Stereotactic System and a manual insertion device. Fluorescence spectra, microvascular blood flow, and tissue grayness were recorded each millimeter along the paths. Biopsies were taken at preplanned positions. The diagnoses were compared with the fluorescence signals. The recordings were plotted against measurement positions and compared. Sites indicating a risk of hemorrhage were counted as well as the time for the procedures. RESULTS Signals were recorded along 28 trajectories, and 78 biopsies were collected. The final diagnosis showed 17 glioblastomas, 2 lymphomas, and 1 astrocytoma grade III. Fluorescence was seen along 23 of the paths with 4 having the peak of 5-ALA fluorescence 3 mm or more from the precalculated target. There was increased microcirculation in 40 of 905 measured positions. The measurement time for each trajectory was 5 to 10 min. CONCLUSION The probe provided direct feedback of increased blood flow along the trajectory and of malignant tissue in the vicinity of the target. The method can increase the precision and the safety of the biopsy procedure and reduce time.

show abstract

“…The LDF component provides this function, as has been documented in more than 130 DBS implantations. 14 , 15 , 20 …”

Section: Discussionmentioning

confidence: 99%

Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe

Richter

Haj‐Hosseini²,

Milos³

et al. 2021

ONSURG

View full text Add to dashboard Cite

show abstract

“…However, since the tissue greyness can be observed using a laser Doppler system based on the intensity of the detected light [11], light intensity could be added as a further network input to differentiate between white and grey matter. Also, the total light intensity could be used to detect the presence of a blood vessel [12], [13]. With this additional input, we believe that the prediction accuracy could be improved.…”

Section: Discussionmentioning

confidence: 99%

“…Side viewing probes are mainly used for vessel detection during biopsy procedures. These include interstitial optical tomography and remission spectroscopy [12], [13].…”

mentioning

confidence: 99%

A Long Short-Term Memory Network for Vessel Reconstruction Based on Laser Doppler Flowmetry via a Steerable Needle

Virdyawan

Baena

2019

IEEE Sensors J.

View full text Add to dashboard Cite

Hemorrhage is one risk of percutaneous intervention in the brain that can be life-threatening. Steerable needles can avoid blood vessels thanks to their ability to follow curvilinear paths, although knowledge of vessel pose is required. To achieve this, we present the deployment of laser Doppler flowmetry (LDF) sensors as an in-situ vessel detection method for steerable needles. Since the perfusion value from an LDF system does not provide positional information directly, we propose the use of a machine learning technique based on a Long Short-term Memory (LSTM) network to perform vessel reconstruction online. Firstly, the LSTM is used to predict the diameter and position of an approaching vessel based on successive measurements of a single LDF probe. Secondly, a "no-go" area is predicted based on the measurement from four LDF probes embedded within a steerable needle, which accounts for the full vessel pose. The network was trained using simulation data and tested on experimental data, with 75% diameter prediction accuracy and 0.27 mm positional Root Mean Square (RMS) Error for the single probe network, and 77% vessel volume overlap for the 4-probe setup.

show abstract

“…18 Other optical technologies that have investigated blood vessel detection in neurosurgery are LDF and DRS; however, the ability to measure blood vessel size using OCT is a significant advantage for risk assessment. 12,71,72 To minimize the number of optical probes used during a single procedure, it would be ideal to have a probe capable of both blood vessel detection during needle descent and tumor margin detection. Such a probe could be either Raman or OCT, or size permitting, a multimodal combination.…”

Section: Rapid Spectroscopic Blood Vessel Detection: An Unmet Clinicamentioning

confidence: 99%

Rise of Raman spectroscopy in neurosurgery: a review

et al. 2020

Self Cite

View full text Add to dashboard Cite

Significance: Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a revolutionary tool for neurosurgeons. Aim: We give a summary of neurosurgical workflows and key translational milestones of RS in clinical use and provide the optics and data science background required to implement such devices. Approach: We performed an extensive review of the literature, with a specific emphasis on research that aims to build Raman systems suited for a neurosurgical setting. Results: The main translatable interest in Raman sensing rests in its capacity to yield label-free molecular information from tissue intraoperatively. Systems that have proven usable in the clinical setting are ergonomic, have a short integration time, and can acquire high-quality signal even in suboptimal conditions. Moreover, because of the complex microenvironment of brain tissue, data analysis is now recognized as a critical step in achieving high performance Raman-based sensing. Conclusions: The next generation of Raman-based devices are making their way into operating rooms and their clinical translation requires close collaboration between physicians, engineers, and data scientists.

show abstract

Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures

Cited by 7 publications

References 54 publications

Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe

Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe

A Long Short-Term Memory Network for Vessel Reconstruction Based on Laser Doppler Flowmetry via a Steerable Needle

Rise of Raman spectroscopy in neurosurgery: a review

Contact Info

Product

Resources

About