Interstitial fluid flow in cancer: implications for disease progression and treatment

Munson, Jennifer M.; Shieh, Adrian C.

doi:10.2147/cmar.s65444

Cited by 189 publications

(203 citation statements)

References 110 publications

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“…During glioma progression, alterations in ECM and elevated hypoxia signaling lead to a compromised and leaky vasculature with poor perfusion. As extracellular fluid accumulates, interstitial fluid pressures can rise dramatically (Alberti et al, 1978;Kullberg and West, 1965;Narayan et al, 1982;Stocchetti and Maas, 2014) and, as this fluid moves down its pressure gradient, into the healthy brain, local increases in fluid shear forces are experienced by tumor cells (Munson and Shieh, 2014). Increased fluid pressure causes tissue compression, which leads to increased migration and transcriptional changes in cancer cells (Butcher et al, 2009).…”

Section: Effects Of Mechanical Changes On Glioma Progressionmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

260

245

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All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surprisingly, disease develops if these mechanical cues are abnormal or are misinterpreted by the cells – for example, when interstitial pressure or compression force aberrantly increases, or the extracellular matrix (ECM) abnormally stiffens. Disease might also develop if the ability of cells to regulate their contractility becomes corrupted. Consistently, disease states, such as cardiovascular disease, fibrosis and cancer, are characterized by dramatic changes in cell and tissue mechanics, and dysregulation of forces at the cell and tissue level can activate mechanosignaling to compromise tissue integrity and function, and promote disease progression. In this Commentary, we discuss the impact of cell and tissue mechanics on tissue homeostasis and disease, focusing on their role in brain development, homeostasis and neural degeneration, as well as in brain cancer.

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Section: Effects Of Mechanical Changes On Glioma Progressionmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

260

245

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“…From an electrical point of view, these junctions contribute to increasing the sensitivity of the tissue to an externally applied electric field. However, from a medical point of view, these interactions can provide important information on tissue health because some diseases related to cell necrosis and/or degeneration (e.g., cancer) can lead to serious deterioration of these interstitial spaces [38,39].…”

Section: Biological Tissuesmentioning

confidence: 99%

Expanding the Repertoire of Dielectric Fractional Models: A Comprehensive Development and Functional Applications to Predict Metabolic Alterations in Experimentally-Inaccessible Cells or Tissues

Farsaci

Tellone

Galtieri

et al. 2018

Fluids

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Abstract:In this paper, we present the theoretical approach developed by us in the network of dielectric fractional theories. In particular, we mention the general aspects of the non-equilibrium thermodynamics, and after an introduction to the interaction between biological tissues and electrical fields, we highlight the role of phenomenological and state equations; therefore, we recall a general formulation on linear response theory. In Section 6, we introduce the classical fractional model. All of this is essential to show the role and the importance of fractional models in the context of thermodynamic dielectric investigations (of living or inert matter), giving a complete vision of the fractional approach. In Sections 7 and 8, we introduce our new fractional model derived from non-equilibrium thermodynamic considerations.

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“…8). Both experimental and theoretical studies have shown that IFP is elevated in the tumors of patients with cancer, and whereas little TIF is found in the tumor interior, it is primarily present near the tumor boundary (9). TIF originates from blood plasma that extravasates from the capillaries through pores and intercellular clefts in the vessel wall.…”

Section: Introductionmentioning

confidence: 99%

Tumor Interstitial Fluid Promotes Malignant Phenotypes of Lung Cancer Independently of Angiogenesis

Li¹,

Li²,

Liu³

et al. 2015

Cancer Prevention Research

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Angiogenesis is necessary for cancer progression, but antiangiogenic therapy actually promotes tumor recurrence, progression, and metastasis. This study focused on the contribution of the tumor interstitial fluid (TIF) to lung cancer progression. TIF was isolated and quantified for 10 mg protein/mL. Malignant driver characteristics of TIF were examined by tumor-initiating cells (TIC), self-renewal, epithelial-mesenchymal transition (EMT), autophagy, and apoptosis in vitro. In vivo tumor model was used to investigate the mechanistic roles of TIF in lung cancer progression. In vitro, TIF exhibited distinct malignant driver characteristics, which led to increased numbers of TICs, increased selfrenewal and EMT, as well as to decreased autophagy and apoptosis under cell starvation conditions. In vivo, the contribution of TIF was similar, as judged by increased TICs indicated by the cancer stem cell marker Nanog, the proliferation marker proliferating cell nuclear antigen, and the EMT marker N-cadherin; TIF also increased the formation of pulmonary tumors. Interestingly, the blockers of inflammation, Na-K-ATPase, and aldosterone receptor decreased TIF-induced tumor progression but increased angiogenesis. Further, we found that the water content of the tissue was positively correlated with the levels of plasma 5-hydroxyindoleacetic acid or tissue aquaporin-1 but not with CD31. However, vadimezan reduced angiogenesis but promoted TIF-induced tumor progression. Our results suggested that TIF could provide better nutrition to the tumor than angiogenesis and that it could promote the development of malignant phenotypes of lung cancer independently of angiogenesis.

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Interstitial fluid flow in cancer: implications for disease progression and treatment

Cited by 189 publications

References 110 publications

Tissue mechanics regulate brain development, homeostasis and disease

Tissue mechanics regulate brain development, homeostasis and disease

Expanding the Repertoire of Dielectric Fractional Models: A Comprehensive Development and Functional Applications to Predict Metabolic Alterations in Experimentally-Inaccessible Cells or Tissues

Tumor Interstitial Fluid Promotes Malignant Phenotypes of Lung Cancer Independently of Angiogenesis

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