Interstitial Cystitis

Baker, William J.; Callahan, Daniel H.

doi:10.1016/s0022-5347(17)65974-3

Cited by 5 publications

(4 citation statements)

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“…Clorpactin WCS-90 first began its medical use in 1955. [16][17][18][19][20][21][22] Since that time the solution has mainly been used as an antiseptic in nonorthopedic medical fields with little reported in orthopedic literature. There are many advantages of Clorpactin solution that warrant further research and investigation in orthopedics.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…15 Since its discover, it has been mainly used as an antiseptic in nonorthopedic surgical procedures with literature reports as early as the 1950s. [16][17][18][19][20][21][22] Both Clorpactin and Dakin's solution belong to the oxidizers class of antiseptics, but more specifically to the subclass oxidative halides. 23 Their mechanism of action works by producing a free-radical that can breakdown biofilms, cell walls, cytoplasmic membranes, proteins, and DNA.…”

mentioning

confidence: 99%

“…15 Since its discover, it has been mainly used as an antiseptic in nonorthopedic surgical procedures with literature reports as early as the 1950s. 16 17 18 19 20 21 22…”

mentioning

confidence: 99%

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Clorpactin: An Alternative Irrigation Method for Total Knee Arthroplasty Joint Infection Revisions

Kotecki

Bradford

2020

J Knee Surg

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Different combinations of irrigation solutions have been used in attempt to eradicate microorganisms for the prevention and treatment of prosthetic joint infections (PJIs). Clorpactin WCS-90 was evaluated as an alternative irrigation intraoperative technique for the treatment of PJI using both debridement, antibiotics, and implant retention (DAIR) and 2-stage total knee arthroplasty (TKA) procedures. We retrospectively reviewed PJIs irrigated with Clorpactin between January 2015 and January 2020. We found 13 patients who underwent a DAIR procedure for an acutely infected primary TKA, 18 patients underwent a 2-stage procedure for a chronically infected primary TKA, two patients underwent a DAIR procedure for an acutely infected revision TKA, and 18 patients underwent a 2-stage procedure for a chronically infected revision TKA. The odds of reinfection and need for additional surgery were analyzed at a mean follow-up of 20 to 26 months between groups. Only one patient (7.69%) became reinfected in the acute infected primary TKA group, three patients (16.67%) in the chronic infected primary TKA group, 0 patients (0%) in the acute infected revision TKA group, and six patients (33.33%) in the chronic infected revision TKA group. When the acute primary TKA infection group was compared with the chronic revision TKA infection group, the odds of reinfection (Chi-square test [χ2] = 21.7, df 3, p < 0.001) and odds of additional surgery (χ2 = 13.6, df 3, p < 0.003) were significantly higher for the chronic revision TKA infection group. Overall, the reinfection rate for DAIR revisions was 6.67% (range = 0–7.69) and 2-stage revisions was 25.00% (range = 16.67–33.33). The use of Clorpactin WCS-90 irrigation prior to wound closure is a useful option for the treatment of acute and chronic knee PJIs. Our study provides evidence that infection eradication with the use of Clorpactin is comparable to other irrigation methods and surgical techniques in reported literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…15 Since its discover, it has been mainly used as an antiseptic in nonorthopedic surgical procedures with literature reports as early as the 1950s. 16 17 18 19 20 21 22…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clorpactin: An Alternative Irrigation Method for Total Knee Arthroplasty Joint Infection Revisions

Kotecki

Bradford

2020

J Knee Surg

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Interstitial Cystitis in Adolescent Girls

1977

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Two cases of interstitial cystitis with typical, large bladder ulcerations in adolescent girls are reported. The specific diagnosis was confirmed histologically after full-thickness segmental resection of the bladder wall at the site of the ulceration during subsequent operations. Contrary to other reports based on subjective clinical findings, interstitial cystitis in children is rare when rigid criteria, including careful histological study, are applied. Treatment in children is the same as in adults and should be conservative. A conscientious attempt should be made to exclude infection and tuberculosis as possible contributors to the symptoms of urinary frequency and discomfort, as well as other causes of bladder abnormality. If conservative management fails to relieve symptoms the bladder may be enlarged in some cases by using a segment of intestine.

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