Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus

Kito, Yoshihiko; Sanders, Kenton M.; Ward, Sean M.; Suzuki, Hiroyoshi

doi:10.1152/ajpgi.00118.2009

Cited by 22 publications

(29 citation statements)

References 37 publications

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“…STDs cause the resting potentials of the SIP syncytium of the fundus to be somewhat more depolarized and may therefore contribute to the basal tone of this region of the stomach. 141 Although STDs are generated in the ICC-IM of the fundus they do not summate to generate slow waves, possibly due to the lack of voltage-dependent Ca 2+ channels in ICC-IM of this region.…”

Section: 114mentioning

confidence: 97%

The Significance of Interstitial Cells in Neurogastroenterology

Blair¹,

Rhee²,

Sanders³

et al. 2014

J Neurogastroenterol Motil

112

111

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Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune cells and smooth muscle cells (SMCs). Over the last number of years the complexity of the interactions between these cell types has begun to emerge. For example, interstitial cells, consisting of both interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor alpha-positive (PDGFRα + ) cells generate pacemaker activity throughout the gastrointestinal (GI) tract and also transduce enteric motor nerve signals and mechanosensitivity to adjacent SMCs. ICC and PDGFRα + cells are electrically coupled to SMCs possibly via gap junctions forming a multicellular functional syncytium termed the SIP syncytium. Cells that make up the SIP syncytium are highly specialized containing unique receptors, ion channels and intracellular signaling pathways that regulate the excitability of GI muscles. The unique role of these cells in coordinating GI motility is evident by the altered motility patterns in animal models where interstitial cell networks are disrupted. Although considerable advances have been made in recent years on our understanding of the roles of these cells within the SIP syncytium, the full physiological functions of these cells and the consequences of their disruption in GI muscles have not been clearly defined. This review gives a synopsis of the history of interstitial cell discovery and highlights recent advances in structural, molecular expression and functional roles of these cells in the GI tract.

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Section: 114mentioning

confidence: 97%

The Significance of Interstitial Cells in Neurogastroenterology

Blair¹,

Rhee²,

Sanders³

et al. 2014

J Neurogastroenterol Motil

112

111

View full text Add to dashboard Cite

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“…Because UPs are markedly diminished in animals deficient in ICC-IM (3,8,20,32), it has been proposed that they are generated in ICC-IM and transmitted electrotonically to smooth muscle, thereby contributing to resting membrane potential (RMP). Furthermore, smooth muscle from animals deficient in ICC-IM has been reported to have a more negative RMP than controls (37), suggesting that ICC-IM contribute to RMP.…”

mentioning

confidence: 99%

Evidence for altered circular smooth muscle cell function in lower esophageal sphincter ofW/W^vmutant mice

Bautista-Cruz

Paterson

2011

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Introductionmentioning

confidence: 99%

“…Potentials generated in ICC-IM also contribute to form a part of slow waves generated in circular smooth muscle of the stomach (Dickens et al, 1999;Dickens et al, 2001;Hirst and Edwards, 2001;Kito and Suzuki, 2003b;Suzuki et al, 2006;Kito et al, 2009). In stomach muscle tissues, recording electrical activities from ICC-MP indicates that the pacemaker potentials are plateau type, with fast rising component (Dickens et al, 1999;Kito et al, 2002a;Kito and Suzuki, 2003b;Kito et al, 2009). The pacemaker potentials conducted to circular smooth muscle form the 1 st component of slow waves, and the potentials conducted to ICC-IM trigger the generation of spontaneous transient depolarizations (STDs) which are conducted to circular smooth muscle cells to form the unitary potentials for constricting the 2 nd component of slow waves (Dickens et al, 1999;Dickens et al, 2001;Hirst and Edwards, 2001;Kito et al, 2002a;Kito and Suzuki, 2003b;Hirst et al, 2006;Kito et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…In stomach muscle tissues, recording electrical activities from ICC-MP indicates that the pacemaker potentials are plateau type, with fast rising component (Dickens et al, 1999;Kito et al, 2002a;Kito and Suzuki, 2003b;Kito et al, 2009). The pacemaker potentials conducted to circular smooth muscle form the 1 st component of slow waves, and the potentials conducted to ICC-IM trigger the generation of spontaneous transient depolarizations (STDs) which are conducted to circular smooth muscle cells to form the unitary potentials for constricting the 2 nd component of slow waves (Dickens et al, 1999;Dickens et al, 2001;Hirst and Edwards, 2001;Kito et al, 2002a;Kito and Suzuki, 2003b;Hirst et al, 2006;Kito et al, 2009). Pacemaker potentials conducted to longitudinal smooth muscle form follower potentials which have a square shape and have rising and falling phases much slower than the pacemaker potential (Dickens et al, 1999;Cousins et al, 2003;Edwards and Hirst, 2003;Hirst et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum

Shigemasa

Kito

Hashitani

et al. 2011

J. Smooth Muscle Res.

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In isolated longitudinal muscle tissues of the guinea-pig stomach antrum, recording electrical responses from smooth muscle cells revealed a periodical generation of follower potentials with variable durations. The I-D relationship, made by plotting the duration as a function of the interval before generating follower potential, was linear. Experiments were carried out to investigate the effects of chemicals which had been known to modulate the release of Ca 2+ from the internal stores (2-aminoethoxy-diphenyl-borate, cyclopiazonic acid, caffeine), inhibit mitochondrial metabolic activity (m-chlorophenyl hydrazone, 2-deoxy-Dglucose, potassium cyanide, rotenone), inhibit ATP-sensitive K-channels distributed in mitochondria (glibenclamide, 5-hydroxydecanoic acid) and inhibit the activity of proteinkinase C (chelerythrine), on the I-D relationship of follower potentials. The effects of depolarization on follower potentials were assessed by stimulating tissues with high potassium solution. Experiments were carried out mainly in the presence of nifedipine which minimized the movements of muscles with no modulation of follower potentials. Cycropiazonic acid and caffeine reduced the slope of I-D relationship, with associated reduction of the duration and frequency of follower potentials. 2-Aminoethoxydiphenyl borate reduced the duration and amplitude and increased the frequency of follower potentials, with depolarization of the membrane, and the effects were simulated by high potassium solution. m-Chlorophenyl hydrazone, potassium cyanide, 2-deoxy-D-glucose, rotenone, 5-hydroxydecanoic acid and glibenclamide reduced the slope of I-D relationship, with associated reduction of the frequency of follower potentials. Chelerythrine did not modulate the slope of I-D relationship, with reduced frequency of follower potentials. It seemed likely that the amount of Ca 2+ released from the internal stores and also mitochondrial function had causal relationship to the duration of pacemaker potentials, suggesting that internal Ca-stores and mitochondria are taking the central role for determining the duration of the pacemaker activity. Proteinkinase C did not seem to participate to the function of mitochondria and internal Ca 2+ stores.

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Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus

Cited by 22 publications

References 37 publications

The Significance of Interstitial Cells in Neurogastroenterology

The Significance of Interstitial Cells in Neurogastroenterology

Evidence for altered circular smooth muscle cell function in lower esophageal sphincter ofW/W^vmutant mice

Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum

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Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus

Cited by 22 publications

References 37 publications

The Significance of Interstitial Cells in Neurogastroenterology

The Significance of Interstitial Cells in Neurogastroenterology

Evidence for altered circular smooth muscle cell function in lower esophageal sphincter ofW/Wvmutant mice

Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum

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Product

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Evidence for altered circular smooth muscle cell function in lower esophageal sphincter ofW/W^vmutant mice