1998
DOI: 10.1016/s0016-5085(98)70586-4
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Interstitial cells of Cajal direct normal propulsive contractile activity in the mouse small intestine

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Cited by 227 publications
(188 citation statements)
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“…Intestinal circular smooth muscle is depolarized in W͞W v mice, which lack small intestinal myenteric networks of interstitial cells of Cajal (20). Therefore, we hypothesized that interstitial cells of Cajal might be the source of the hyperpolarizing CO. Interstitial cells of Cajal generate rhythmic changes in membrane potential and are essential for gastrointestinal motility (20)(21)(22). Interstitial cells of Cajal in the murine small intestine were found to express HO-2, suggesting that they may provide a source for CO (10).…”
Section: Resultsmentioning
confidence: 99%
“…Intestinal circular smooth muscle is depolarized in W͞W v mice, which lack small intestinal myenteric networks of interstitial cells of Cajal (20). Therefore, we hypothesized that interstitial cells of Cajal might be the source of the hyperpolarizing CO. Interstitial cells of Cajal generate rhythmic changes in membrane potential and are essential for gastrointestinal motility (20)(21)(22). Interstitial cells of Cajal in the murine small intestine were found to express HO-2, suggesting that they may provide a source for CO (10).…”
Section: Resultsmentioning
confidence: 99%
“…16,17 It has also been shown that W/W v mice have markedly disrupted duodenal slow waves and contractions due to the loss of ICC-MY in the small bowel that is associated with duodenal stasis and duodeno-gastric reflux. 29 Moreover, weak contractions in these mutants 15 may lead to poor gastric clearing of refluxed bile, leading to the high incidence of antral erosions and ulceration. 16,17 Duodeno-gastric bile reflux is an important clinical problem with implications for gastritis, bile esophagitis and cancer.…”
Section: Discussionmentioning
confidence: 99%
“…3 In fact, normal peristaltic activity in the small bowel after gastric emptying of a liquid was absent in W/W v mutant mice that do not have ICC-AP. 3 ICC-AP are characterized by elongated cell bodies with extremely long, thin, ramified cell processes interconnected by close apposition contacts and gap junctions.…”
mentioning
confidence: 99%
“…3 In fact, normal peristaltic activity in the small bowel after gastric emptying of a liquid was absent in W/W v mutant mice that do not have ICC-AP. 3 ICC-AP are characterized by elongated cell bodies with extremely long, thin, ramified cell processes interconnected by close apposition contacts and gap junctions. ICC-AP have many ultrastructural features in common with smooth muscle cells and fibroblasts, but can be identified because of a unique combination of ultrastructural features together with unique structural associations with nerves and smooth muscle cells.…”
mentioning
confidence: 99%