Interstitial brachytherapy in soft tissue sarcomas

Chaudhary, Ashok J.; Laskar, Siddharth; Badhwar, Rajesh

doi:10.1007/bf03038985

Cited by 26 publications

(13 citation statements)

References 17 publications

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“…The local control rates and long-term survival of patients with cervical carcinoma Stage IIB treated with a combination of external beam irradiation and intracavitary brachytherapy range from 65% to 75%, respectively [7,15,18,20]. Carcinoma of the cervix Stage IIB has a relatively wide spectrum of disease depending on the degree of parametrial involvement, bulk of the central disease and proliferative or infiltrative nature of the disease qualifying some of these patients to be locally advanced.…”

Section: Discussionmentioning

confidence: 99%

“…Interstitial brachytherapy with Iridium-192 has been routinely used in a variety of sites such as carcinoma of breast, cervix, vagina, prostate, anal canal, penis and soft tissue sarcomas [7,8,12,33,38]. Transperineal interstitial brachytherapy in carcinoma of the cervix has also been used as an alternative method of improving dose distribution in locally advanced and recurrent cervical cancers, especially in situations where a standard intracavitary application is not possible [2,3,24].…”

Section: Discussionmentioning

confidence: 99%

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Transperineal Low-Dose Rate Iridium-192 Interstitial Brachytherapy in Cervical Carcinoma Stage IIB

et al. 2001

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Interstitial brachytherapy after external beam irradiation in patients with cervical carcinoma Stage IIB results in acceptable local control, survival and complication rates. Increased dose to the cervical disease results in improved local control and survival and should therefore be considered while optimizing brachytherapy treatment plans. Comparison of the results with those of standard intracavitary therapy remains to be proven in a randomized trial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transperineal Low-Dose Rate Iridium-192 Interstitial Brachytherapy in Cervical Carcinoma Stage IIB

et al. 2001

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“…Eine präoperative und bei größeren oder subfaszial gelegenen Tumoren auch postoperative MRT-Untersuchung bildet die Grundlage für die [18,24,28]. Im Rahmen dieser Behandlung folgt der initialen Brachytherapie mit einem kleinvolumigen Boost (15-30 Gy) schließlich die perkutane Radiotherapie (45)(46)(47)(48)(49)(50).…”

Section: Bestrahlungsplanung Und Dosierung Der Perkutanen Fraktionierunclassified

Radiotherapie der Weichteilsarkome – Teil einer multidisziplinären Strategie

Pape

Orth

Engers

et al. 2008

Wien Klin Wochenschr

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The management of soft tissue sarcoma has evolved from a solitary surgical treatment to an interdisciplinary multimodal approach including radiotherapy. These fundamental changes are the result of increased knowledge in tumor biology, radiation sensitivity and the improvement in modern radiation therapy techniques. A successful effective therapy regimen strongly depends on distinct preoperative diagnostics, preoperative conception of the surgical intervention and an experienced oncological team. Of significant importance for the prognosis is early diagnosis as well as tumor excision with a wide negative margin. However, even after complete wide resection in sano, the use of postoperative radiotherapy can further improve local control and should therefore be applied to the majority of patients. Consequently, radiotherapy should only be omitted in cases in which the tumor has been excised with a very wide negative margin; this implies, however, high quality of surgery and distinct histopathological analysis. Patients with non- or questionable resectable tumors, should be referred for pre-operative radiotherapy in order to improve the surgical results. Recent studies have underlined the efficiency of modern radiotherapy regimens. The different radiotherapy regimens will be highlighted against the background of tumor stage and tumor resectibility.

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“…Werden zwei unabhängige Parameter auf statistische Signifikanz getestet, so steigt das oben genannte 5%-Risiko auf etwa das Doppelte, also 10%, an. Werden n unabhängige statistische Tests durchgeführt, so steigt der Fehler erster Art gemäß der folgenden Formel an: In insgesamt 18 Arbeiten wurde eine multivariate Analyse durchgeführt [6,17,19,32,39,45,62,64,65,77,101,114,138,145,154,155,170,178]. In zwei dieser Arbeiten wurde der Fehler erster Art entsprechend adjustiert [6,178].…”

Section: Statistische Signifikanz Und Der Fehler Erster Artunclassified

Multiple Signifikanztests und ihre Bedeutung bei der Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

Beck‐Bornholdt¹,

Dubben²

2000

Strahlenther Onkol

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Interstitial brachytherapy in soft tissue sarcomas

Abstract: The sequential combination of limited surgery and tumor bed brachytherapy with or without external radiotherapy has been established as an effective alternative to more ablative procedures like amputation. Histologic grade has proven to be a significant factor determining local control.

Cited by 26 publications

References 17 publications

Transperineal Low-Dose Rate Iridium-192 Interstitial Brachytherapy in Cervical Carcinoma Stage IIB

Transperineal Low-Dose Rate Iridium-192 Interstitial Brachytherapy in Cervical Carcinoma Stage IIB

Radiotherapie der Weichteilsarkome – Teil einer multidisziplinären Strategie

Multiple Signifikanztests und ihre Bedeutung bei der Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

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