Interstitial brachytherapy for penile carcinoma: a multicentric survey (259 patients)

Rozan, R; Albuisson, Éliane; Giraud, B; Donnarieix, D.; Delannes, M.; Pigneux, J; Hoffstetter, S.; Gerbaulet, A.; Chinet-Charrot, P.; Goupil, A; Couette, J.E.; Hay, M.; Chaplain, Gilles; Castelain, B.; Hassel, Bjørnar; Méré, P.; Cellier, P.

doi:10.1016/0167-8140(95)01574-z

Cited by 109 publications

(61 citation statements)

References 23 publications

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“…In our series, the ®rst symptom was penile mass in 32 patients (78%), and glans and prepuce were the predominant sites in 28 patients (68%). Rozan and colleagues [13] reported in their large survey of 259 patients with penile carcinoma, 130 with tumour involving the glans, 44 the prepuce, 83 in both sites and 2 patients with shaft in®ltration alone.…”

Section: Discussionmentioning

confidence: 99%

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Zouhair

Coucke

Jeanneret

et al. 2001

European Journal of Cancer

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To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35±76 years). According to the International Union Against Cancer (UICC) 1997 classi®cation, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classi®cation was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20±331 months). In a median period of 12 months (range 5±139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy AEpostoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5-and 10-year survival rates were 57% (95% con®dence interval (CI), 41±73%) and 38% (95% CI, 21± 55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41±73%) and 48% (95% CI, 32±64%), respectively. In patients treated with primary radiotherapy, 5-and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22±50%) and 18% (95% CI, 2±34%), respectively. In multivariate analyses, survival was signi®cantly in¯uenced by the N-classi®-cation, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squamous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no di erence in terms of survival between patients treated by surgery and those treated by primary radiotherapy AEsalvage surgery, with 39% having organ preservation. #

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Section: Discussionmentioning

confidence: 99%

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Zouhair

Coucke

Jeanneret

et al. 2001

European Journal of Cancer

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“…Some authors prefer brachytherapy to the external beam radiation [9, 10, 11, 25, 27, 28, 29]. According Rozan et al [9], organ preservation was achieved in 78% of patients treated with brachytherapy compared to only 64% who received external beam radiation.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, radiation, chemotherapy and radiochemotherapy emerged as methods of conservative treatment of penile carcinoma [9, 10, 11, 12, 13]. Despite the large number of reports, the place of conservative therapy still is not clearly defined in the management of penile carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Is Conservative Organ–Sparing Treatment of Penile Carcinoma Justified?

Gotsadze

Matveev²,

Zak

et al. 2000

European Urology

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“…71 Superior local control is achieved using brachytherapy, with 5-year penile preservation rates of 70% to 88% and 10-year penile preservation rates of 67% to 72% (Level of evidence 2b). 69,[72][73][74][75] Cause-specific survival is similar to primary surgical approaches as salvage surgery is highly effective. 69,75 Squamous carcinoma of the penis is a highly radiosensitive tumour, but radical doses in this site can result in complications including soft tissue necrosis (12%) or meatal stenosis (9%).…”

Section: Recommendationsmentioning

confidence: 99%

“…69,[72][73][74][75] Cause-specific survival is similar to primary surgical approaches as salvage surgery is highly effective. 69,75 Squamous carcinoma of the penis is a highly radiosensitive tumour, but radical doses in this site can result in complications including soft tissue necrosis (12%) or meatal stenosis (9%). 69 Soft tissue necrosis often responds to conservative measures, including hyperbaric oxygen treatment, and only rarely requires amputation.…”

Section: Recommendationsmentioning

confidence: 99%

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

Richter

Ruether

Wood

et al. 2013

CUAJ

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Interstitial brachytherapy for penile carcinoma: a multicentric survey (259 patients)

Cited by 109 publications

References 23 publications

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Is Conservative Organ–Sparing Treatment of Penile Carcinoma Justified?

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

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Interstitial brachytherapy for penile carcinoma: a multicentric survey (259 patients)

Cited by 109 publications

References 23 publications

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?

Is Conservative Organ&ndash;Sparing Treatment of Penile Carcinoma Justified?

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

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Is Conservative Organ–Sparing Treatment of Penile Carcinoma Justified?