Interspecific Associations between Circulating Antioxidant Levels and Life‐History Variation in Birds

Cohen, Alan A.; McGraw, Kevin J.; Wiersma, Popko; Williams, Joseph B.; Robinson, W. Douglas; Robinson, Tara Rodden; Brawn, Jeffrey D.; Ricklefs, Robert E.

doi:10.1086/589456

Cited by 103 publications

(128 citation statements)

References 100 publications

(88 reference statements)

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“…At least in birds, it has recently been shown that the antioxidant capacity has a complex pattern relative to longevity (Cohen et al, 2008), whereby higher antioxidant levels were generally characteristic of 'fast-paced' life-history traits such as rapid development, low survival, smaller body size, larger clutch size and higher massspecific metabolic rate. Thus, convincing a priori predictions about how cells of tropical and temperate birds might resist oxidative and non-oxidative stress are difficult to make.…”

Section: Discussionmentioning

confidence: 99%

Linkages between the life-history evolution of tropical and temperate birds and the resistance of their cells to oxidative and non-oxidative chemical injury

Jiménez

Harper

Queenborough

et al. 2012

Journal of Experimental Biology

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SUMMARYA fundamental challenge facing physiological ecologists is to understand how variation in life history at the whole-organism level might be linked to cellular function. Thus, because tropical birds have higher annual survival and lower rates of metabolism, we hypothesized that cells from tropical species would have greater cellular resistance to chemical injury than cells from temperate species. We cultured dermal fibroblasts from 26 tropical and 26 temperate species of birds and examined cellular resistance to cadmium, H 2 O 2 , paraquat, thapsigargin, tunicamycium, methane methylsulfonate (MMS) and UV light. Using ANCOVA, we found that the values for the dose that killed 50% of cells (LD 50 ) from tropical birds were significantly higher for H 2 O 2 and MMS. When we tested for significance using a generalized least squares approach accounting for phylogenetic relationships among species to model LD 50 , we found that cells from tropical birds had greater tolerance for Cd, H 2 O 2 , paraquat, tunicamycin and MMS than cells from temperate birds. In contrast, tropical birds showed either lower or no difference in tolerance to thapsigargin and UV light in comparison with temperate birds. These findings are consistent with the idea that natural selection has uniquely fashioned cells of long-lived tropical bird species to be more resistant to forms of oxidative and non-oxidative stress than cells from shorterlived temperate species.Supplementary material available online at

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Section: Discussionmentioning

confidence: 99%

Linkages between the life-history evolution of tropical and temperate birds and the resistance of their cells to oxidative and non-oxidative chemical injury

Jiménez

Harper

Queenborough

et al. 2012

Journal of Experimental Biology

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“…Similarly, the parallel increase of uric acid levels is not well supported by human studies, which report decreases, increases, or no change with age . Although uric acid in blood may contribute to controlling oxidative stress (Ames et al 1981;Machin et al 2004;Costantini 2008; but see Cohen et al 2007Cohen et al , 2008, its role in avoiding lipid peroxidation could be minor because it is, in fact, a hydrosoluble compound . Moreover, uric acid levels in plasma can be influenced by the protein content in the diet Smith et al 2007) or by protein catabolism associated with starvation (e.g., Alonso-Alvarez and Ferrer 2001).…”

Section: Discussionmentioning

confidence: 99%

Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species

Alonso‐Álvarez

Pérez‐Rodríguez

García

et al. 2010

Physiological and Biochemical Zoology

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Oxidative stress is the imbalance between the production of pro-oxidant substances and the level of antioxidant defenses, which leads to oxidative damage. It has been proposed that senescence is the result of accumulated oxidative damage throughout life. In birds, the sources of individual variability in oxidative stress are still poorly understood. Among these sources, age, as related to senescence, should be particularly relevant. Furthermore, recent findings suggest that breeding effort may also deeply influence susceptibility to oxidative stress. However, there is still no evidence of a link between breeding effort and oxidative damage in any vertebrate. Here we analyzed 288 captive red-legged partridges (Alectoris rufa) across a wide age range (i.e., 1-8 yr old), thus including potentially senescent birds. In spite of limitations due to the crosssectional approach, results revealed that old birds produced less offspring and endured higher levels of oxidized glutathione and peroxidized lipids in erythrocytes than did middle-aged individuals. Old birds also showed higher plasma total antioxidant status and uric acid levels than did younger birds, but lower amounts of circulating carotenoids. Furthermore, hatching success was negatively correlated to lipid peroxidation in females but not in males, supporting the hypothesis that breeding effort promotes oxidative damage.

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“…Thus, the amount of RS produced during exercise may be different if measured in a bird as opposed to a non-flying mammal, and birds may be more susceptible to RS damage via lipid peroxidation of stored fats. Further information on the interspecific relationship between BMR, lifespan and RS production can be found in other thorough reviews (Barja, 2007;Brand et al, 2004;Cohen et al, 2008;Costantini et al, 2010b;Hulbert and Else, 2000;Hulbert et al, 2007;Jimenez et al, 2014;Munshi-South and Wilkinson, 2010;Perez-Campo et al, 1998;Selman et al, 2012). …”

Section: Among-species Differences In Bmrmentioning

confidence: 99%

The role of the antioxidant system during intense endurance exercise: lessons from migrating birds

Cooper-Mullin

McWilliams

2016

Journal of Experimental Biology

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During migration, birds substantially increase their metabolic rate and burn fats as fuel and yet somehow avoid succumbing to overwhelming oxidative damage. The physiological means by which vertebrates such as migrating birds can counteract an increased production of reactive species (RS) are rather limited: they can upregulate their endogenous antioxidant system and/or consume dietary antioxidants ( prophylactically or therapeutically). Thus, birds can alter different components of their antioxidant system to respond to the demands of long-duration flights, but much remains to be discovered about the complexities of RS production and antioxidant protection throughout migration. Here, we use bird migration as an example to discuss how RS are produced during endurance exercise and how the complex antioxidant system can protect against cellular damage caused by RS. Understanding how a bird's antioxidant system responds during migration can lend insights into how antioxidants protect birds during other life-history stages when metabolic rate may be high, and how antioxidants protect other vertebrates from oxidative damage during endurance exercise.

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Interspecific Associations between Circulating Antioxidant Levels and Life‐History Variation in Birds

Cited by 103 publications

References 100 publications

Linkages between the life-history evolution of tropical and temperate birds and the resistance of their cells to oxidative and non-oxidative chemical injury

Linkages between the life-history evolution of tropical and temperate birds and the resistance of their cells to oxidative and non-oxidative chemical injury

Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species

The role of the antioxidant system during intense endurance exercise: lessons from migrating birds

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