Interspecies Comparison of Pentosidine Accumulation and Its Correlation With Age in Birds

Fallon, Jesse A.; Cochrane, Robert L.; Dorr, Brian S.; Klandorf, H.

doi:10.1642/0004-8038(2006)123[870:icopaa]2.0.co;2

Cited by 11 publications

(17 citation statements)

References 20 publications

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“…It forms cross‐links between amino acid residues in collagen and accumulates with age in birds (Fallon, Cochrane, Dorr, & Klandorf, ; Iqbal, Probert, Alhumadi, & Klandorf, ). Pentosidine has been shown to accumulate in a linear fashion in terrestrial birds and some seabirds including California gulls ( Larus californicus ) (Chaney, Blemings, Bonner, & Klandorf, ) and Double‐crested cormorants ( Phalocrocorax auritus ) (Fallon et al, ). This technique has yielded age estimates with a precision of 2–4 years in wild birds (Chaney et al, ; Fallon et al, ; Rattiste et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Pentosidine has been shown to accumulate in a linear fashion in terrestrial birds and some seabirds including California gulls ( Larus californicus ) (Chaney, Blemings, Bonner, & Klandorf, ) and Double‐crested cormorants ( Phalocrocorax auritus ) (Fallon et al, ). This technique has yielded age estimates with a precision of 2–4 years in wild birds (Chaney et al, ; Fallon et al, ; Rattiste et al, ). However, in a study of another long‐lived seabird, the Bridled tern ( Onychoprion anaethetus ), no correlation between pentosidine levels and age was found (Labbé, ).…”

Section: Discussionmentioning

confidence: 99%

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Age estimation in a long‐lived seabird (Ardenna tenuirostris) using DNA methylation‐based biomarkers

Paoli-Iseppi

Deagle

Polanowski

et al. 2019

Molecular Ecology Resources

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Age structure is a fundamental aspect of animal population biology. Age is strongly related to individual physiological condition, reproductive potential and mortality rate. Currently, there are no robust molecular methods for age estimation in birds. Instead, individuals must be ringed as chicks to establish known‐age populations, which is a labour‐intensive and expensive process. The estimation of chronological age using DNA methylation (DNAm) is emerging as a robust approach in mammals including humans, mice and some non‐model species. Here, we quantified DNAm in whole blood samples from a total of 71 known‐age Short‐tailed shearwaters (Ardenna tenuirostris) using digital restriction enzyme analysis of methylation (DREAM). The DREAM method measures DNAm levels at thousands of CpG dinucleotides throughout the genome. We identified seven CpG sites with DNAm levels that correlated with age. A model based on these relationships estimated age with a mean difference of 2.8 years to known age, based on validation estimates from models created by repeated sampling of training and validation data subsets. Longitudinal observation of individuals re‐sampled over 1 or 2 years generally showed an increase in estimated age (6/7 cases). For the first time, we have shown that epigenetic changes with age can be detected in a wild bird. This approach should be of broad interest to researchers studying age biomarkers in non‐model species and will allow identification of markers that can be assessed using targeted techniques for accurate age estimation in large population studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Age estimation in a long‐lived seabird (Ardenna tenuirostris) using DNA methylation‐based biomarkers

Paoli-Iseppi

Deagle

Polanowski

et al. 2019

Molecular Ecology Resources

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“…, Fallon et al. ]) can even be used in lieu of abundance to provide the balance equation for integrating vital rate data (Conn et al. ).…”

Section: Discussionmentioning

confidence: 99%

Understanding the demographic drivers of realized population growth rates

Koons

Arnold

Schaub

2017

Ecological Applications

133

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Identifying the demographic parameters (e.g., reproduction, survival, dispersal) that most influence population dynamics can increase conservation effectiveness and enhance ecological understanding. Life table response experiments (LTRE) aim to decompose the effects of change in parameters on past demographic outcomes (e.g., population growth rates). But the vast majority of LTREs and other retrospective population analyses have focused on decomposing asymptotic population growth rates, which do not account for the dynamic interplay between population structure and vital rates that shape realized population growth rates (λt=Nt+1/Nt) in time-varying environments. We provide an empirical means to overcome these shortcomings by merging recently developed "transient life-table response experiments" with integrated population models (IPMs). IPMs allow for the estimation of latent population structure and other demographic parameters that are required for transient LTRE analysis, and Bayesian versions additionally allow for complete error propagation from the estimation of demographic parameters to derivations of realized population growth rates and perturbation analyses of growth rates. By integrating available monitoring data for Lesser Scaup over 60 yr, and conducting transient LTREs on IPM estimates, we found that the contribution of juvenile female survival to long-term variation in realized population growth rates was 1.6 and 3.7 times larger than that of adult female survival and fecundity, respectively. But a persistent long-term decline in fecundity explained 92% of the decline in abundance between 1983 and 2006. In contrast, an improvement in adult female survival drove the modest recovery in Lesser Scaup abundance since 2006, indicating that the most important demographic drivers of Lesser Scaup population dynamics are temporally dynamic. In addition to resolving uncertainty about Lesser Scaup population dynamics, the merger of IPMs with transient LTREs will strengthen our understanding of demography for many species as we aim to conserve biodiversity during an era of non-stationary global change.

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“…Accumulation of Ps with age has been documented in numerous mammal and avian species (Chaney, Blemings, Bonner, & Klandorf, ; Dammann, Sell, Begall, Strauch, & Monnier, ; Fallon, Cochrane, Dorr, & Klandorf, ; Fallon, Radke, et al., ; Iqbal, Probert, Al‐humadi, & Klandorf, ; Sell et al., ). Comparison of Ps accumulation in mammals and birds has demonstrated that Ps accumulates at different rates in different species, and longer‐lived species accumulate Ps at slower rates than shorter‐lived species (Fallon, Cochrane, et al., ; Fallon, Radke, et al., ; Sell et al., ). Cooey et al.…”

Section: Introductionmentioning

confidence: 99%

“…() found that relatively small skin samples (6 mm biopsy) can be used to quantify Ps concentrations, allowing for nondestructive sampling of wildlife. The ubiquity of Ps, its accumulation with age, the inverse relationship between accumulation rate of Ps and longevity, and the ability to nondestructively sample suggest that Ps is suitable to use as a biomarker to age a wide variety of organisms (Chaney et al., ; Fallon, Cochrane, et al., ; Fallon, Radke, et al., ).…”

Section: Introductionmentioning

confidence: 99%

Using pentosidine and hydroxyproline to predict age and sex in an avian species

Dorr

Stahl

Hanson‐Dorr

et al. 2017

Ecology and Evolution

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All living organisms are subject to senescence accompanied by progressive and irreversible physiological changes. The error damage and cross‐linking theories suggest that cells and tissues are damaged by an accumulation of cross‐linked proteins, slowing down bodily processes and resulting in aging. A major category of these cross‐linked proteins are compounds called advanced glycation end products (AGEs). We investigated the relationship between accumulation of the AGE, pentosidine (Ps), and hydroxyproline (HYP) a post‐translationally modified amino acid, with age, sex, and breeding status (breeder/nonbreeder) from skin samples of known age (i.e., banded as fledglings), free‐ranging Double‐crested Cormorants (Phalacrocorax auritus, Lesson 1831). We developed multivariate models and evaluated the predictive capability of our models for determining age and breeding versus nonbreeding birds. We found significant relationships with Ps and HYP concentration and age, and Ps concentration and sex. Based on our two‐class model using Ps and HYP as explanatory variables, we were able to accurately determine whether a cormorant was a breeder or nonbreeder in 83.5% of modeled classifications. Our data indicate that Ps and HYP concentrations can be used to determine breeding status of cormorants and potentially age of cormorants although sex‐specific models may be necessary. Although the accumulation of Ps explained the greatest amount of variance in breeding status and age, importantly, Ps covaried with HYP and combined improved prediction of these demographics in cormorants. Our data support the error damage and cross‐linking theories of aging. Both Ps and HYP increase predictably in cormorants and are predictive of age and breeding status. Given the ubiquity of these biomarkers across taxa, their use in estimating demographic characteristics of animals could provide a powerful tool in animal ecology, conservation, and management.

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Interspecies Comparison of Pentosidine Accumulation and Its Correlation With Age in Birds

Cited by 11 publications

References 20 publications

Age estimation in a long‐lived seabird (Ardenna tenuirostris) using DNA methylation‐based biomarkers

Age estimation in a long‐lived seabird (Ardenna tenuirostris) using DNA methylation‐based biomarkers

Understanding the demographic drivers of realized population growth rates

Using pentosidine and hydroxyproline to predict age and sex in an avian species

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