Intersite Reliability of Diffusion Tensor Imaging on Two 3T Scanners

Kamagata, Koji; Shimoji, Keigo; Hori, Masaaki; Nishikori, Akira; Tsuruta, Kenji; Yoshida, Misao; Kamiya, Kazutaka; Irie, Ryusuke; Suzuki, Michitaka; Kyogoku, Shinsuke; Suzuki, Yukiko; Sato, Noriko; Aoki, Shigeki

doi:10.2463/mrms.2014-0077

Cited by 11 publications

(10 citation statements)

References 12 publications

(11 reference statements)

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“…Fox et al ( 12 ) reported inter-vendor and inter-session CV of FA as 6.8–9.1%. In contrast, other studies reported ranges of CV of FA as 1–3% ( 13 ) and less than 4% ( 10 ). Our results are more consistent with the latter studies, suggesting that FA exhibits good reliability.…”

Section: Discussionmentioning

confidence: 77%

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Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies

et al. 2018

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ObjectiveTo evaluate the inter-vendor and inter-session reliability of diffusion tensor imaging (DTI) and relevant parameters.Materials and MethodsThis prospective study included 10 healthy subjects (5 women and 5 men; age range, 25–33 years). Each subject was scanned twice using 3T magnetic resonance scanners from three different vendors at two different sites. A voxel-wise statistical analysis of diffusion data was performed using Tract-Based Spatial Statistics. Fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) values were calculated for each brain voxel using FMRIB's Diffusion Toolbox.ResultsA repeated measures analysis of variance revealed that there were no significant differences in FA values across the vendors or between sessions; however, there were significant differences in MD values between the vendors (p = 0.020). Although there were no significant differences in inter-session MD and inter-session/inter-vendor RD values, a significant group × factor interaction revealed differences in MD and RD values between the 1st and 2nd sessions conducted by the vendors (p = 0.004 and 0.006, respectively).ConclusionAlthough FA values exhibited good inter-vendor and inter-session reliability, MD and RD values did not show consistent results. Researchers using DTI should be aware of these limitations, especially when implementing DTI in multicenter studies.

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Section: Discussionmentioning

confidence: 77%

“…Several studies have reported the reproducibility of DTI over time using one or more scanners from the same vendor and demonstrated acceptable agreement ( 8 10 ). Other studies have examined the inter-vendor reliability of DTI but reported conflicting results ( 4 6 8 11 12 13 ).…”

Section: Introductionmentioning

confidence: 99%

Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies

et al. 2018

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“…In a very recent study, Kamagata et al 17 scanned 7 volunteers at two sites, both using 3T Philips Achieva scanners. By using several analytical methods, including voxel-wise comparison with TBSS, atlas-based analysis, and tract specific analysis, they reported CoV inter-site variability <4% in the case of tract-specific analysis, and a CoV <6% by using the atlas-based analysis.…”

Section: Discussionmentioning

confidence: 99%

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

Palacios

Martin

Boss

et al. 2016

AJNR Am J Neuroradiol

120

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BACKGROUND & PURPOSE Precision Medicine is an approach to disease diagnosis, treatment and prevention which relies on quantitative biomarkers that minimize the variability of individual patient measurements. The aim of this study is to assess the inter-site variability after harmonization of a high angular resolution 3T diffusion tensor imaging protocol across 13 scanners at the 11 academic medical centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) multisite study. MATERIALS AND METHODS Diffusion MRI was acquired from a novel isotropic diffusion phantom developed at the National Institute of Standards and Technology (NIST) and from the brain of a traveling volunteer on thirteen 3T MR scanners representing three major vendors (General Electric, Philips and Siemens). Means of the DTI parameters and their coefficients of variation (CoVs) across scanners were calculated for each DTI metric and white matter tract. RESULTS For the NIST diffusion phantom, the CoV of apparent diffusion coefficient (ADC) across the 13 scanners was < 3.8% for a range of diffusivities from 0.4 to1.1×10−6 mm2/s. For the volunteer, the CoVs across scanners of the 4 primary DTI metrics, each averaged over the entire white matter skeleton, were all < 5%. In individual white matter tracts, large central pathways showed good reproducibility with the CoV consistently below 5%. However, smaller tracts showed more variability with the CoV of some DTI metrics reaching 10%. CONCLUSION The results suggest the feasibility of standardizing DTI across 3T scanners from different MR vendors in a large-scale neuroimaging research study.

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“…multi-center study). 6 , 7 QC itself is widely performed in daily clinics, but standard water phantoms for such general checks are not optimal for DTI validation because they do not contain diffusional anisotropy. Therefore, special DTI-QC phantoms that have an appropriate diffusional anisotropy are needed.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Glass Capillary Plates and Polyethylene Fiber Bundles as Phantoms to Assess the Quality of Diffusion Tensor Imaging

Tachibana

Kershaw

et al. 2018

magn reson med sci

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Purpose:The purpose of this study was to evaluate the suitability of two phantoms, one made of capillary plates and the other polyethylene fibers, for assessing the quality of diffusion tensor imaging (DTI).Methods:The first phantom was a stack of glass capillary plates with many parallel micropores (CP). The second phantom was a bundle of polyethylene fiber Dyneema held together with a thermal shrinkage tube (Dy). High resolution multi-shot echo planar imaging (EPI) DTI acquisitions were performed at b-values of 0 and 1000 s/mm2 and diffusion-times (Tdiff) of 37.7 and 97.7 ms on a preclinical 7T MRI scanner. Thirty diffusion-encoding directions were used. The data were used to calculate the fractional anisotropy (FA), mean diffusivity (MD), and angular dispersion (AD). Further acquisitions were performed at b-values from 0 to 8000 s/mm2 in 14 steps with the diffusion gradient applied parallel (axial) and perpendicular (radial) to the Z direction. On the other hand, the data acquired with a 3T MRI scanner were used to confirm that measurements on a clinical machine are consistent with the 7T MRI results.Results:The dependence of FA, MD and AD on Tdiff was smaller for the Dy than for the CPs. The b-value-dependent signal attenuations in the axial direction at Tdiff = 37.7 and 97.7 ms were similar for both phantoms. In the radial direction, Dy demonstrated similar b-value attenuation to that of in vivo tissue for both Tdiffs, but the attenuation for the CPs was affected by the change in Tdiff. Parameter estimates were similar for 3T and 7T MRI.Conclusion:The characteristics of the CP indicate that it can be used as a restricted-diffusion dominant phantom, while the characteristics of the Dy suggest that it can be used as a hindered-diffusion dominant phantom. Dy may be more suitable than CP for DTI quality control.

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Intersite Reliability of Diffusion Tensor Imaging on Two 3T Scanners

Cited by 11 publications

References 12 publications

Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies

Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

Comparison of Glass Capillary Plates and Polyethylene Fiber Bundles as Phantoms to Assess the Quality of Diffusion Tensor Imaging

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