Intersexuality in the Blue Mussel<i>Mytilus edulis</i>Complex (Mytilidae) from the Baltic Sea and the Danish Strait

Dublinowska, Magda; Smolarz, Katarzyna; Zabrzańska, Sandra; Larsson, Josefine; Czerniawska, Natalia

doi:10.4003/006.034.0105

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…The induction of female-specific sex transcripts such as vitellogenin has been well documented in male and intersex fish after EDC exposure . Our results, combined with data from other lab studies − and field studies, ,,,− suggest similar impacts to bivalves, which may lead to developmental impairments, intersex, or gender reversal.…”

Section: Resultssupporting

confidence: 71%

Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis

Blalock

Robinson

Loguinov

et al. 2018

Environ. Sci. Technol.

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Transcriptomics, high-throughput assays, and adverse outcome pathways (AOP) are promising approaches applied to toxicity monitoring in the 21st century, but development of these methods is challenging for nonmodel organisms and emerging contaminants. For example, Endocrine Disrupting Compounds (EDCs) may cause reproductive impairments and feminization of male bivalves; however, the mechanism linked to this adverse outcome is unknown. To develop mechanism-based biomarkers that may be linked through an AOP, we exposed Mytilus edulis to 17-alpha-ethinylestradiol (5 and 50 ng/L) and 4-nonylphenol (1 and 100 μg/L) for 32 and 39 days. When mussels were exposed to these EDCs, we found elevated female specific transcripts and significant female-skewed sex ratios using a RT-qPCR assay. We performed gene expression analysis on digestive gland tissue using an M. edulis microarray and through network and targeted analyses identified the nongenomic estrogen signaling pathway and steroidogenesis pathway as the likely mechanisms of action for a putative AOP. We also identified several homologues to genes within the vertebrate steroidogenesis pathway including the cholesterol side chain cleavage complex. From this AOP, we designed the Coastal Biosensor for Endocrine Disruption (C-BED) assay which was confirmed in the laboratory and tested in the field.

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Section: Resultssupporting

confidence: 71%

Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis

Blalock

Robinson

Loguinov

et al. 2018

Environ. Sci. Technol.

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“…Another notable change caused to the gills of exposed groups was the appearance of fibrous tissue. Dublinowska et al, (2016) reported some dysfunctional gonads of the blue mussels, Mytilus edulis that contain fibrous tissue as a result of pollution effects. In the current work, irregular folds of gill filaments were detected.…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic effects of Bisphenol A on hormonal disruption and histological alterations in the freshwater clam, Caelatura nilotica (Cailliaud, 1827)

Sheir¹,

Mohamad²,

Osman³

et al. 2020

Egypt. J. of Aquatic Biolo. and Fish.

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Freshwater bivalves play important ecological roles, especially in shallow waters; rivers, lakes, and estuaries. Bivalves are widely used to assess environmental pollution because they respond with measurable physiological and morphological change. Additionally, they cannot escape pollution and therefore serve as sessile bioindicators. So, they can tolerate and accumulate high levels of heavy metals, pesticides and hormonal disrupting chemicals and then show signs of pathology (

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Section: Similarities Between Cms and Duimentioning

confidence: 99%

“…[100] Interestingly, Bivalvia is one of the rare animal groups in which gynodioecy and trioecy, a system often associated with evolutionary transitioning from gynodioecy to dioecy (or reverse), have been functionally identified, and to our knowledge, mainly involves species with DUI or closely-related species. [16][17][18][19][101][102][103] In gynodioecious plants, theory predicts that female frequency might be highly variable among populations when sex is determined by interactions between several nuclear and cytoplasmic genetic factors, some of which may not be present in all populations. [104] For example, if a female parent gives rise to all-female progeny when crossed with different pollen-parents, one might suspect that the female carried a type of CMS factor for which nuclear Rf alleles were relatively rare or absent in the population.…”

Section: Cyto-nuclear Sex Determination and Gynodioecymentioning

confidence: 99%

Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?

et al. 2022

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Animal and plant species exhibit an astonishing diversity of sexual systems, including environmental and genetic determinants of sex, with the latter including genetic material in the mitochondrial genome. In several hermaphroditic plants for example, sex is determined by an interaction between mitochondrial cytoplasmic male sterility (CMS) genes and nuclear restorer genes. Specifically, CMS involves aberrant mitochondrial genes that prevent pollen development and specific nuclear genes that restore it, leading to a mixture of female (male‐sterile) and hermaphroditic individuals in the population (gynodioecy). Such a mitochondrial‐nuclear sex determination system is thought to be rare outside plants. Here, we present one possible case of CMS in animals. We hypothesize that the only exception to the strict maternal mtDNA inheritance in animals, the doubly uniparental inheritance (DUI) system in bivalves, might have originated as a mitochondrial‐nuclear sex‐determination system. We document and explore similarities that exist between DUI and CMS, and we propose various ways to test our hypothesis.

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Intersexuality in the Blue MusselMytilus edulisComplex (Mytilidae) from the Baltic Sea and the Danish Strait

Cited by 9 publications

References 31 publications

Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis

Transcriptomic and Network Analyses Reveal Mechanistic-Based Biomarkers of Endocrine Disruption in the Marine Mussel, Mytilus edulis

Acute and chronic effects of Bisphenol A on hormonal disruption and histological alterations in the freshwater clam, Caelatura nilotica (Cailliaud, 1827)

Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?

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