Intersex and other reproductive disruption of fish in wastewater effluent dominated Colorado streams

Woodling, John D.; Lopez, Elena M.; Maldonado, Tammy A.; Norris, David O.; Vajda, Alan M.

doi:10.1016/j.cbpc.2006.04.019

Cited by 104 publications

(93 citation statements)

References 14 publications

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“…As most of these substances are designed to be biologically active, they can affect sensitive aquatic organisms even at very low concentrations (Santos et al, 2010), hence the name "micropollutant". For instance, endocrine effects on fish and mussel populations such as intersex, reproductive disruption or feminization of males have been observed in rivers downstream of municipal WWTP outfalls (Alan et al, 2008;Gagné et al, 2011;Tetreault et al, 2011;Tyler and Jobling, 2008;Vethaak et al, 2005;Woodling et al, 2006). These effects were attributed to the release of endocrine-active chemicals such as the synthetic estrogen 17α-ethinylestradiol (found in contraceptive pills), natural estrogens estrone and 17β-estradiol or nonylphenol.…”

Section: Introductionmentioning

confidence: 99%

Treatment of micropollutants in municipal wastewater: Ozone or powdered activated carbon?

Margot

Kienle

Magnet³

et al. 2013

Science of The Total Environment

675

404

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Highlights• Micropollutants are efficiently removed by both ozone and powdered activated carbon• Specific substances were removed more efficiently by ozone• Powdered activated carbon effectively removed a wider range of pollutants• Both treatments significantly reduced the toxicity of WWTP effluent AbstractMany organic micropollutants present in wastewater, such as pharmaceuticals and pesticides, are poorly removed in conventional wastewater treatment plants (WWTPs). To reduce the release of these substances into the aquatic environment, advanced wastewater treatments are necessary. In this context, two large-scale pilot advanced treatments were tested in parallel over more than one year at the municipal WWTP of Lausanne, Switzerland. The treatments were: i) oxidation by ozone followed by sand filtration (SF) and ii) powdered activated carbon (PAC) adsorption followed by either ultrafiltration (UF) or sand filtration. More than 70 potentially problematic substances (pharmaceuticals, pesticides, endocrine disruptors, drugs metabolites and other common chemicals) were regularly measured at different stages of treatment. Additionally, several ecotoxicological tests such as the yeast estrogen screen, a combined algae bioassay and a fish early life stage test were performed to evaluate effluent toxicity. Both treatments significantly improved the effluent quality. Micropollutants were removed on average over 80% compared with raw wastewater, with an average ozone dose of 5.7 mg O 3 l -1 or a PAC dose between 10 and 20 mg l -1 . Depending on the chemical properties of the substances (presence of electron-rich moieties, charge and hydrophobicity), either ozone or PAC performed better. Both advanced treatments led to a clear reduction in toxicity of the effluents, with PAC-UF performing slightly better overall. As both treatments had, on average, relatively similar efficiency, further criteria relevant to their implementation were considered, including local constraints (e.g., safety, sludge disposal, disinfection), operational feasibility and cost. For sensitive receiving waters (drinking water resources or recreational waters), the PAC-UF treatment, despite its current higher cost, was considered to be the most suitable option, enabling good removal of most micropollutants and macropollutants without forming problematic by-products, the strongest decrease in toxicity and a total disinfection of the effluent.

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Section: Introductionmentioning

confidence: 99%

Treatment of micropollutants in municipal wastewater: Ozone or powdered activated carbon?

Margot

Kienle

Magnet³

et al. 2013

Science of The Total Environment

675

404

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“…Through these actions environmental estrogens affect vertebrate reproduction across a wide range of doses causing reduced fertility and fecundity, altered reproductive behavior, gonad morphological changes, and decreased embryonic survival (25)(26)(27)(28)(29)(30)(31)(32)(33)(34). Although both sexes are affected, males exhibit the highest degree and number of detrimental effects.…”

mentioning

confidence: 99%

“…Although both sexes are affected, males exhibit the highest degree and number of detrimental effects. Specific male defects caused by environmental estrogen exposures in vertebrates include: intersex (25,29), diminished sperm count (27,(35)(36)(37), genital tract alterations (38), increased germ cell apoptosis (30,33), and male induced embryonic mortality (31,39).…”

mentioning

confidence: 99%

Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol

Brown

Schultz

Cloud

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Environmental contaminants that mimic native estrogens (i.e., environmental estrogens) are known to significantly impact a wide range of vertebrate species and have been implicated as a source for increasing human male reproductive deficiencies and diseases. Despite the widespread occurrence of environmental estrogens and recognized detrimental effects on male vertebrate reproduction, no specific mechanism has been determined indicating how reduced fertility and/or fecundity is achieved. Previous studies show that male rainbow trout, Oncorhynchus mykiss, exposed to the environmental estrogen 17␣-ethynylestradiol (EE2) before gamete formation and fertilization produce progeny with significantly reduced embryonic survival. To determine whether this observed decrease results from sperm chromosome alterations during spermatogenesis, male rainbow trout were exposed to 10 ng of EE2/l for 50 days. After exposure, semen was collected and sperm aneuploidy levels analyzed with two chromosome markers by fluorescent in situ hybridization. In vitro fertilizations were also conducted by using control and exposed sperm crossed to eggs from an unexposed female for offspring analysis. Evaluations for nucleolar organizer region number and karyotype were performed on developing embryos to determine whether sperm aneuploidy translated into embryonic aneuploidy. Results conclusively show increased aneuploid sperm formation due to EE2 exposure. Additionally, embryonic cells from propagated progeny of individuals possessing elevated sperm aneuploidy display high levels of embryonic aneuploidy. This study concludes that EE2 exposure in sexually developing male rainbow trout increases levels of aneuploid sperm, providing a mechanism for decreased embryonic survival and ultimately diminished reproductive success in EE2 exposed males.aneuploidy ͉ EE2 ͉ xenoestrogens

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“…Those chemicals are commonly used in household and industrial products and can enter the environment through municipal and industrial wastewater discharges, agricultural runoff, solid-waste leaching, and garbage incineration (Campbell et al 2006;Kawagoshi et al 2003;Sidhu et al 2005). The occurrence of EDCs in the environment has been reported worldwide (Gong et al 2009;Mayer et al 2007;Pojana et al 2007;Yoon et al 2010), and increasing evidences have suggested possible adverse effects of EDCs to aquatic organisms even at environmentally relevant concentrations (Bahamonde et al 2014;Vajda et al 2011;Woodling et al 2006).…”

mentioning

confidence: 99%

Occurrence and Fate of Selected Endocrine-Disrupting Chemicals in Water and Sediment from an Urban Lake

Huang

Lin

et al. 2014

Arch Environ Contam Toxicol

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Occurrence of five endocrine-disrupting chemicals (EDCs)-bisphenol-A (BPA), triclosan (TCS), 17a-ethinyl estradiol (EE2), benzophenone-3, and 4-methylbenzylidene camphor-were monitored in East Lake, the largest urban lake in China. Other than EE2, all selected EDCs were detected at least once in the lake water with concentrations B89.1 ng/L. EDCs were detected with greater occurrence in spring than in other seasons. In lake sediment, TCS was detected at the greatest concentration (30.9 ng g -1 ), whereas BPA and EE2 were not detected. Spatial distribution of the EDCs in the lake water and the lake sediment showed similar patterns, and greater EDC residuals were found from those sites with known wastewater input. The linear adsorption coefficients (K d ) varied from 17.9 to 1,017 L kg -1 and were related to the octanolwater partition coefficient (K ow ) values of the compounds. Photodegradation was a major process removing the EDCs from the lake water, and the presence of dissolved organic material and NO 3 -in the lake water can accelerate the photodegradation process. Degradation of the EDCs in the lake sediment was relatively slow and occurred mainly due to the microbial processes. All compounds were found more persistent under anoxic conditions than under oxic conditions.

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Intersex and other reproductive disruption of fish in wastewater effluent dominated Colorado streams

Cited by 104 publications

References 14 publications

Treatment of micropollutants in municipal wastewater: Ozone or powdered activated carbon?

Treatment of micropollutants in municipal wastewater: Ozone or powdered activated carbon?

Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol

Occurrence and Fate of Selected Endocrine-Disrupting Chemicals in Water and Sediment from an Urban Lake

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