Intersectional HIV and Chronic Pain Stigma: Implications for Mood, Sleep,  and Pain Severity

Hobson, Joanna M.; Gilstrap, Shannon R.; Owens, Michael A.; Gloston, Gabrielle F.; Ho, Michael; Gathright, Jenna M.; Dotson, Hannah F.; White, Dyan M.; Cody, Shameka L.; Thomas, Stephen J.; Goodin, Burel R.

doi:10.1177/23259582221077941

Cited by 10 publications

(15 citation statements)

References 47 publications

(65 reference statements)

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“…More details of the findings and procedures from this study can be found elsewhere. [41][42][43][44] However, none of these published studies overlap with the current study.…”

Section: Methodsmentioning

confidence: 55%

Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain

et al. 2023

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Background: Physical stressors can cause a physiological response that can contribute to an increase in mitochondrial dysfunction and mtDNA damage. People living with HIV (PWH) are more likely to suffer from chronic pain and may be more susceptible to mitochondrial dysfunction following exposure to a stressor. We used Quantitative Sensory Testing (QST) as an acute painful stressor in order to investigate whether PWH with/without chronic pain show differential mitochondrial physiological responses. Methods: The current study included PWH with (n=26), and without (n=29), chronic pain. Participants completed a single session that lasted approximately 180 minutes, including QST. Blood was taken prior to and following the QST battery for assays measuring mtDNA damage, mtDNA copy number, and mtDNA damage-associated molecular pattern (DAMP) levels (i.e. ND1 and ND6). Results: We examined differences between those with and without pain on various indicators of mitochondrial reactivity following exposure to QST. However, only ND6 and mtDNA damage were shown to be statistically significant between pain groups. Conclusion: PWH with chronic pain showed greater mitochondrial reactivity to laboratory stressors. Consequently, PWH and chronic pain may be more susceptible to conditions in which mitochondrial damage/dysfunction play a central role, such as cognitive decline.

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“…More details of the findings and procedures from this study can be found elsewhere. [41][42][43][44] However, none of these published studies overlap with the current study.…”

Section: Methodsmentioning

confidence: 55%

Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain

et al. 2023

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“… 35 , 36 Across studies, most participants were female, with only 2 studies having more male participants. 21 , 24 Four studies had an entirely female sample. 35 , 36 , 41 , 49 Eleven studies provided information about the ethnic background of participants, with over half of these primarily recruiting White participants ( k = 6).…”

Section: Resultsmentioning

confidence: 99%

“…One study recruited only White participants, 35 and 3 recruited samples comprised primarily of Black participants. 21 , 24 , 45 The ethnicity of the participants in 2 further studies was undetermined, as they were described as being “Belgian” 59 or “European” 2 in origin.…”

Section: Resultsmentioning

confidence: 99%

A systematic review with meta-analyses of the association between stigma and chronic pain outcomes

Hickling,

Allani,

Cella

et al. 2024

Pain

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Stigma is common in people experiencing chronic pain and there are indications that it may adversely affect pain outcomes. However, to date, there is no systematic review exploring the impact of stigma on chronic pain-related outcomes. This systematic review and meta-analysis aimed to examine the association between stigma and key chronic pain outcomes and differences in stigma between pain conditions. Seven databases were searched for studies reporting a measure of association between stigma and at least one pain outcome in adults with chronic pain. Studies were screened by 2 independent researchers. Nineteen studies met eligibility criteria and data were extracted, quality-assessed, and narratively synthesised and meta-analysed where possible. Meta-analyses of bivariate cross-sectional correlations demonstrated significant positive correlations between stigma and pain intensity, disability, and depression, with small to moderate effects. Data from 2 prospective studies and those only reporting multivariate analyses that were not included in meta-analyses further supported these findings. There was some evidence that individuals who experience pain conditions with less clear pathophysiology may report greater stigma, although more research is needed. The review highlights that there is a growing number of studies on stigma in the pain field showing an adverse association between stigma and chronic pain outcomes.

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“…A US study ( n = 120 PWH) also found that those reporting any chronic pain had higher ISI scores than those without pain [31]. Another recent publication of note enrolled exclusively PWH with chronic pain ( n = 91 PWH) and showed that those with more HIV stigma and chronic pain stigma reported higher ISI scores [38 ▪▪ ]. Sequential mediation analyses showed that the relationships between both chronic pain stigma and HIV stigma with pain severity were mediated through depressive symptoms and insomnia symptoms, highlighting the complex relationships between HIV, stigma, depression, sleep, and pain.…”

Section: Painmentioning

confidence: 95%

Do sleep disturbances contribute to comorbidities in HIV?

Kunisaki

2022

Current Opinion in HIV and AIDS

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Purpose of reviewTo highlight recent publications about sleep disorders and sleep health in adult persons with HIV (PWH), with a focus on how sleep relates to comorbidities in PWH. Recent findingsSleep disorders are more common in PWH than in seronegative controls, especially insomnia, with four different recent studies estimating insomnia prevalence in PWH at 21--35%. Sleep apnea prevalence estimates in PWH have varied widely. Most studies suggest PWH do not have higher sleep apnea prevalence compared with controls, though definitions of sleep apnea may affect these analyses. Comorbidities recently associated with sleep in PWH include myocardial infraction (insomnia), depressive symptoms (insomnia and restless legs syndrome), and pain (insomnia). Cognition associations with sleep were inconsistent and may depend on data collection and analytic methods. Sleep health dimensions are uncommonly reported, but PWH appear to report worse sleep health dimensions and these demonstrated mixed associations with cognition and depressive symptoms in recent studies.

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Intersectional HIV and Chronic Pain Stigma: Implications for Mood, Sleep, and Pain Severity

Cited by 10 publications

References 47 publications

Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain

Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain

A systematic review with meta-analyses of the association between stigma and chronic pain outcomes

Do sleep disturbances contribute to comorbidities in HIV?

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