2021
DOI: 10.1073/pnas.2111267118
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Intersection of regulatory pathways controlling hemostasis and hemochorial placentation

Abstract: Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling trophoblast cell development. TS cell differentiation was characterized by acquisition of transcript signatures indicative of an endothelial cell-like phenotype, which was highlighted by the expression of anticoagulation factors including tissue factor pathway inhibit… Show more

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Cited by 21 publications
(34 citation statements)
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“…Global-LOF Junctional zone dysgenesis and failed intrauterine trophoblast cell invasion [176] Ahr Global-LOF Maternal AHR regulates TCDD-induced endovascular trophoblast cell invasion [125] Tfpi Trophoblast-LOF Inhibition of endovascular and interstitial trophoblast cell invasion [48] a LOF, loss of function.…”
Section: Mmp12mentioning
confidence: 99%
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“…Global-LOF Junctional zone dysgenesis and failed intrauterine trophoblast cell invasion [176] Ahr Global-LOF Maternal AHR regulates TCDD-induced endovascular trophoblast cell invasion [125] Tfpi Trophoblast-LOF Inhibition of endovascular and interstitial trophoblast cell invasion [48] a LOF, loss of function.…”
Section: Mmp12mentioning
confidence: 99%
“…The first wave of trophoblast cell invasion is restricted to endovascular trophoblast cell colonization of uterine spiral arteries/arterioles, which is initiated at the earliest stages of placentation and is a prominent feature of the midgestation mesometrial decidua [ 34 , 35 , 46 ]. Endovascular trophoblast cells mimic and supplant endothelial cells [ 34 , 35 , 47 , 48 ], destabilize vascular smooth muscle [ 49 ], and become embedded in fibrin [ 12 ]. A second wave of trophoblast cell invasion begins after gestation day 13.5, as endovascular trophoblast cells penetrate blood vessels beyond the decidua-myometrial boundary and interstitial trophoblast cell invasion is initiated [ 34 , 35 , 36 , 46 ].…”
Section: Life Cycle Of Invasive Trophoblast Cellsmentioning
confidence: 99%
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