Abstract:70Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the 71 major high-affinity cell-surface phosphate importer of Saccharomyces cerevisiae and a crucial 72 element in the phosphate homeostatic system of this model yeast. We found that loss of 73Candida albicans Pho84 attenuated virulence in Drosophila and murine oropharyngeal and 74 disseminated models of invasive infection, and conferred hypersensitivity to neutrophil killing. 75Susceptibility of cells lacking Pho84 to ne… Show more
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