Interseasonal RSV infections in Switzerland – rapid establishment of a clinician-led national reporting system (RSV EpiCH)

Hammerstein, Alix L von; Aebi, Christoph; Barbey, Florence; Berger, Christoph; Buettcher, Michael; Casaulta, Carmen; Egli, Adrian; Gebauer, Mathias; Guerra, Beatrice; Kahlert, Christian; E, Kellner; Kottanattu, Lisa; Opota, Onya; Mann, Christian; Sauteur, Patrick M. Meyer; Plebani, Margherita; Ritz, Nicole; Testi, Chiara; Niederhäusern, Valentin von; Wagner, Noémie; Zimmermann, Petra; Zucol, Franziska; Agyeman, Philipp; Trück, Johannes

doi:10.4414/smw.2021.w30057

Cited by 18 publications

(11 citation statements)

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“…However, this marked upsurge is likely to have been further precipitated by the widespread relaxation of COVID-19 mitigation measures such as travel restrictions, school closures, use of face masks and physical distancing. The findings are indeed consistent with the widespread resurgence of other community-transmitted respiratory infections, whose circulation in most of Europe had until recently largely ceased [ 11 , 12 ]. The interruption in the transmission of respiratory and enteric viruses, including EV-D68, has probably created large cohorts of susceptible young children without prior exposure or immunity to any such virus, potentially creating the conditions for largescale outbreaks of severe respiratory disease in this age group this winter.…”

Section: Discussionsupporting

confidence: 78%

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

et al. 2021

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We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europe.

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Section: Discussionsupporting

confidence: 78%

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

et al. 2021

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“…Hammerstein et al reported a shift in the usual RSV season in both infants and children, which coincided with the lifting of PHSMs and a local decline in COVID-19 cases. 68 A change in RSV seasonality was also found in Germany. A dramatic decrease of RSV cases was observed in winter during 2020 to 2021.…”

Section: Dovepressmentioning

confidence: 82%

The Impact of the COVID-19 Pandemic on Respiratory Syncytial Virus Infection: A Narrative Review

Chuang¹,

Lin²,

Wang³

et al. 2023

IDR

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Respiratory syncytial virus (RSV) is one of the most common respiratory viruses. It not only affects young children but also the elderly and immunocompromised patients. After the emergence of SARS-CoV-2 and the corona virus disease 2019 (COVID-19) era, a dramatic reduction in RSV activity was found, which coincided with the implementation of public health and social measures (PHSMs). However, the correlation is more complicated than we initially thought. After PHSMs were gradually lifted, a seasonality shift and a delayed RSV outbreak with greater number of infected patients were found in numerous countries, such as Israel, Australia, South Africa, New Zealand, France, United States, and Japan. Several hypotheses and possible reasons explaining the interaction between SARS-CoV-2 and RSV were mentioned. Since RSV vaccinations are still under investigation, administration of palivizumab should be considered in high-risk patients. In the post-COVID-19 era, greater attention should be paid to a further resurgence of RSV. In this narrative review, we conducted a thorough review of the current knowledge on the epidemiology of RSV during the COVID-19 era, the out-of-season outbreak of RSV, and the data on co-infection with RSV and SARS-CoV-2.

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“…In January 2021, the multicenter database EpiCH began collecting data on RSV infections among hospitalized children in Switzerland [12]. Our CLRS expanded upon EpiCH's approach by additionally collecting data on the necessity for respiratory support, an aspect which enabled reporting on national and potentially regional impacts for general wards and intensive care units.…”

Section: Discussionmentioning

confidence: 99%

High burden of RSV hospitalizations in Germany 2021–2022

et al. 2022

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Background Public health measures implemented to mitigate the effects of the COVID-19 pandemic disrupted the worldwide transmission of endemic respiratory viruses such as RSV, as well as other typical, seasonal, and viral respiratory pathogens. Methods From October 18, 2021 to March 31, 2022, RSV cases admitted to German pediatric hospitals were monitored via a newly established, national, Clinician-Led Reporting System (CLRS) that recorded patient age and type of respiratory support. A subanalysis of the first 4 months of the monitoring period was additionally performed. ResultsIn October 2021, a total of 471 hospitalized pediatric RSV cases per day were documented by 67 reporting hospitals. By January 2022, this number dropped to three cases at 11 hospitals (median of reporting hospitals: 37 (11%)). During these months, the median of hospitalized children on general wards and intensive care units was 133 and 15, respectively. In the subanalysis conducted to examine the period October to January, an average of 3.6 ± 2.2 patients per hospital per day were hospitalized on general wards (median 4 cases; range 0.3-8 cases), whereas 0.4 ± 2.2 patients were on intensive care units (median 0.3 cases; range 0-0.9 cases), with 11.5% receiving respiratory support. The majority of patients were under 2 years old. ConclusionThe overall burden of out-of-season RSV cases was extraordinarily high in Germany in 2021-2022. The newly established CLRS may help evaluate and, therefore, better allocate local and national pediatric care resources.

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Interseasonal RSV infections in Switzerland – rapid establishment of a clinician-led national reporting system (RSV EpiCH)

Cited by 18 publications

References 0 publications

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

The Impact of the COVID-19 Pandemic on Respiratory Syncytial Virus Infection: A Narrative Review

High burden of RSV hospitalizations in Germany 2021–2022

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