Interrupted 131I Procedures for Patients With Differentiated Thyroid Cancer

Abstract

Retrospective cohort-Level III.

Differentiated thyroid cancer theranostics: radioiodine and beyond

“…Traditionally, this high level has been achieved by withholding thyroxine therapy for 4-6 weeks after NTT or TT, causing endogenous TSH to rise. 52,53 The resultant hypothyroidism can impact the patients quality of life (QoL) and imbalance of several biochemical parameters especially in the elderly [54][55][56][57][58] A highly purified, recombinant form of the naturally occurring human protein TSH, rhTSH, has been developed and used as an alternative to withholding thyroxine to facilitate RAI ablation. 53,59 It is a highly purified, recombinant form of the naturally occurring human protein TSH (rhTSH), produced by recombinant DNA technology.…”

“…52,53 The resultant hypothyroidism can impact the patients quality of life (QoL) and imbalance of several biochemical parameters especially in the elderly [54][55][56][57][58] A highly purified, recombinant form of the naturally occurring human protein TSH, rhTSH, has been developed and used as an alternative to withholding thyroxine to facilitate RAI ablation. 53,59 It is a highly purified, recombinant form of the naturally occurring human protein TSH (rhTSH), produced by recombinant DNA technology. 60 Recombinant human thyrotropin is currently approved by many international authorities including the United States Food and Drug Administration and Health Canada for use in patient preparation for RAI remnant ablation in patients who have undergone a NT or TT for DTC and who do not have evidence of distant metastases.…”

Impacto do TSH elevado no PET/CT com DOTATATO-68Ga em pacientes com carcinoma diferenciado de tireóide iodoresistentes

“…Estes custos se devem a uma redução de aproximadamente 59% das horas trabalhadas durante o período de suspensão hormonal e também um aumento das taxas de cancelamento de procedimentos [50][51]. Além disso, pacientes submetidos a RIT tanto com rhTSH quanto com suspensão da levotiroxina apresentaram respostas bioquímicas e sobrevida livre de doença semelhantes [52].…”