Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology

Krämer, Richard; Rajappa, Rajit

doi:10.1016/j.coph.2022.102198

Cited by 2 publications

(3 citation statements)

References 49 publications

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“…Optogenetics has several advantages when compared to functional magnetic resonance imaging (fMRI). Through genetic manipulation and light‐sensitive proteins, optogenetics allows for selective activation or inhibition of specific types or regions of neurons, providing insight into the function and interactions of distinct neuronal populations 31 . Moreover, optogenetics offers spatial localization at the cellular level, enabling researchers to directly control or record the activity of specific neuronal populations.…”

Section: Discussionmentioning

confidence: 99%

“…Through genetic manipulation and light‐sensitive proteins, optogenetics allows for selective activation or inhibition of specific types or regions of neurons, providing insight into the function and interactions of distinct neuronal populations. 31 Moreover, optogenetics offers spatial localization at the cellular level, enabling researchers to directly control or record the activity of specific neuronal populations. However, fMRI provides information about overall brain region activity with relatively low spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

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Bibliometric analysis of hot literature on neural circuit research

Du,

Mauki,

Zuo

2023

Ibrain

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Numerous brain diseases have been attributed to abnormalities in the connections of neural circuits. Exploration of neural circuits may give enlightenment in treating some intractable brain diseases. Here, we screened all publications on neural circuits in the Web of Science database from 2007 to 2022 and analyzed the research trends through VOSviewer, CiteSpace, Microsoft Excel 2019, and Origin. The findings revealed a consistent upward trend in research on neural circuits during this period. The United States emerged as the leading contributor, followed by China and Japan. Among the top 10 institutions with the largest number of publications, both the United States and China have a strong presence. Notably, the Chinese Academy of Sciences demonstrated the highest publication output, closely followed by Stanford University. In terms of influential authors, Karl Deisseroth stood out as one of the most prominent investigators. During this period, the majority of publications and citations on neural circuit research were found in highly influential journals including NEURON, NATURE JOURNAL OF NEUROSCIENCE, and so forth. Keyword clustering analysis highlighted the increasing focus on neural circuits and photogenetics in neuroscience research, and the reconstruction of neural circuits has emerged as a crucial research direction in brain science. In conclusion, over the past 15 years, the increasing high‐quality publications have facilitated research development of neural circuits, indicating a promising prospect for investigations on neurological and psychiatric diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of hot literature on neural circuit research

Du,

Mauki,

Zuo

2023

Ibrain

View full text Add to dashboard Cite

show abstract

“…To date, the interrogation of GABA A RS can also be manipulated in the gene level via conjugating a PTL onto specific subunits of GABA A RS modified genetically, realising the photoregulation of endogenous GABA A RS. Relevant works have been reviewed by Kramer and Rajappa [16].…”

Section: Ion Channelsmentioning

confidence: 99%

Azobenzene-based photoswitches: a promising element in the field of life science

Fang

2022

International Conference on Biomedical and Intelligent Systems (IC-BIS 2022)

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Photoswitches are a group of molecules which can modulate biochemical features via isomerisation. Azobenzene is a prevalent structure used in photoswitches. The key feature of azobenzene is the light-stimulated interconversion between cis- and trans- forms, with diverse activity in its two forms. Owing to the various synthetic methods of azobenzene derivates and their photoswitchable features, azobenzene-based photoswitches have been promising elements in the field of life science, both for photopharmacological drugs and research tools. As photopharmacological drugs, they can interact with the traditional targets (ion channels, transporters, etc.) and be introduced as novel elements in some new technology (Proteolysis Targeting Chimeras). As research tools, they are used to regulate the conformation and activity of some biomolecules such as proteins and peptides via structural restrictions or target protein degradation. Several barriers remain, however, especially regarding these molecules’ use in vivo and clinic. This paper aims to integrate properties, mechanisms, synthetic methods, and applications of azobenzene-based photoswitches, meanwhile, providing some challenges in this field.

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Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology

Cited by 2 publications

References 49 publications

Bibliometric analysis of hot literature on neural circuit research

Bibliometric analysis of hot literature on neural circuit research

Azobenzene-based photoswitches: a promising element in the field of life science

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