Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues

Yamashita, Megumi; Prakriya, Murali

doi:10.1016/bs.mie.2021.02.012

Methods in Enzymology

2021

DOI: 10.1016/bs.mie.2021.02.012

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Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues

Megumi Yamashita

Murali Prakriya

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2023

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Epilepsy and genetics: A review

Sibiya,

Jebi,

Nikita

et al. 2023

JLS

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The term "epilepsy" refers to a wide range of conditions, the majority of which are triggered by interactions between many genes and environmental variables. Genetic epilepsies caused by single-gene alterations or specific structural chromosomal anomalies such as micro-deletions are much infrequent. These rare genetic forms of epilepsy often exhibit distinct clinical features and can provide valuable insights into the underlying biological mechanisms involved in seizure generation. The advancements in epilepsy genetics over the last ten to twenty years have opened up new avenues for diagnosis and treatment. For instance, many types of genetic epilepsies are discussed to show the multiple paths that might lead from genes to seizures. It has become evident that different genetic alterations can disrupt neuronal excitability, synaptic function, ion channel activity, or other critical biological processes, ultimately leading to seizure activity. Furthermore, the identification of specific genetic variants associated with drug response or treatment resistance has provided valuable insights into personalized therapeutic strategies for individuals with epilepsy.

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Epilepsy and genetics: A review

Sibiya,

Jebi,

Nikita

et al. 2023

JLS

View full text Add to dashboard Cite

show abstract

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Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues

Cited by 1 publication

References 45 publications

Epilepsy and genetics: A review

Epilepsy and genetics: A review

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