Interrelationships of Selenium, Cadmium, and Arsenic in Mammalian Teratogenesis

Holmberg, Robert E.; Ferm, Vergil H.

doi:10.1080/00039896.1969.10665508

Cited by 140 publications

(31 citation statements)

References 10 publications

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“…Intravenous studies of a single dose of sodium arsenate at 5, 15, 20, 25 and 40 mg kg -1 (2, 6, 8, 10 and 16 mg As kg -t) in Syrian hamsters on day 8, with sacrifice between days 12 to 15, resulted in marked foetotoxicity at all concentrations except for the 5 mg kg -1 dose (Ferm and Carpenter, 1968;Holmberg and Ferm, 1969;Ferm et al, t971). At the higher doses of arsenate, there was an increased incidence of dead foetuses with most of the live foetuses displaying primarily: exencephaly, encephalocele, cleft lip, cleft palate, renal agenesis, with skeletal defects involving ribs and vertebrae.…”

Section: Intravenous Studiesmentioning

confidence: 95%

“…Considering the known metabolic antagonism between selenium and arsenic, ttolmberg and Ferm (1969) reported that 2 mg kg -I of sodium selenite caused a reduction in the number of foetal resorptions and congeni~ malformations induced by arsenate. There were 49% malformed foetuses in the arsenate group compared to 19% in the selenium protected group.…”

Section: Lntraperitoneal Studiesmentioning

confidence: 99%

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Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

Goldman

Dacre

1991

Environ Geochem Health

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This review examines and evaluates the literature on the ability of inorganic arsenic compounds to cause cancer in humans and laboratory animals. The epidemiological data that supports the position that inorganic arsenical derivatives are carcinogenic in humans is convincing and difficult to deny because of their consistency. These data are from studies of different occupational exposures such as smelter and pesticide workers, as well as from studies of drinking water, wines and medicinal tonics that contained or were contaminated with inorganic compounds of arsenic. Indeed, positive dose-response relationships between cancer incidence or mortality with many inorganic arsenical substances have been shown. Despite the presence of data which confuse the interpretation and evaluation of epidemiological data, associated neoplasms of the lungs, skin and gastrointestinal systems have been observed as a result of exposure to inorganic arsenic compounds.The mechanism of carcinogenicity of inorganic arsenical substances in humans is unknown. Inorganic arsenic compounds are not carcinogenic in laboratory animals by most routes of administration. However, further studies (subchronic, chronic, carcinogenic) using intratracheal and other conventional routes in other animal species would appear to be warranted. Moreso, especially since there is no evidence that organic arsenic compounds are carcinogenic in numerous mammalian species. Inorganic derivatives of arsenic are not mutagenic but may be teraiogenic. This latter conclusion is dependent on the method of administration and size of the dose, as well as on the species of animal used for the study.

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Section: Intravenous Studiesmentioning

confidence: 95%

Section: Lntraperitoneal Studiesmentioning

confidence: 99%

Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

Goldman

Dacre

1991

Environ Geochem Health

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“…Prolonged as well as acute exposure gives rise to changes in liver, kidneys, and spleen of the experimental animals (Richardson et al, 1974). Some metals are highly teratogenic in mammalian embryos such as rat (Beaudoin, 1974), hamster (Ferm, 1972;Holmberg and Ferm, 1969), and mouse (Spyker and Smithberg, 1972). Some of the malformations observed were hydrocephalus, skeletal abnormalities including limb bud, cleft lip and palate, exencephaly, and urogenital abnormalities.…”

Section: Introductionmentioning

confidence: 94%

Teratogenicity of metals to chick embryos

Gilani

Alibhai

1990

Journal of Toxicology and Environmental Health

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The present study examines the effects of heavy metals on chick embryogenesis. The metals included were cadmium, arsenic, cobalt, copper, indium, iron, manganese, and molybdenum. Salts of each of the metals were dissolved in saline and injected into the air sacs on d 2 of incubation. Dose levels varied with the metal to be tested. Control eggs were injected with an equivalent volume of saline (0.1 ml/egg). On d 14, the live embryos were removed from the eggs and examined for gross malformations. From the LD50 values, the toxicity relationship between the metals is cadmium greater than arsenic greater than cobalt greater than copper greater than indium greater than molybdenum greater than manganese greater than iron. The LD50 values were 3, 9, 38, 58, 121, 333, 765, and 1185 micrograms/egg, respectively. The gross malformations observed were reduced body size, micromelia, twisted neck, hemorrhage, everted viscera, and microphthalmia. Arsenic and cobalt were observed to be more teratogenic than other metals. This study showed that the metals tested were both toxic and teratogenic to varying degrees in chick embryogenesis.

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“…Although prevention of testicular damage is the most striking response, selenium is also capable of alleviating other effects of cadmium. Mortality of rats given lethal doses of cadmium (Parizek et al, 1971) and the teratogenicity of cadmium (Holmberg and Ferm, 1969) are markedly reduced by the administration of selenium. Other effects of cadmium involving the female reproductive tract that are prevented by selenium include the selective cadmium-induced damage to non-ovulating ovaries, effects on the placenta, and the toxicity of cadmium that becomes apparent during the latter period of pregnancy (Parizek et aI., 1971(Parizek et aI., , 1974.…”

Section: Interaction Of Selenium With Cadmiummentioning

confidence: 97%

Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver

Whanger

1985

Advances in Nutritional Research

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Interrelationships of Selenium, Cadmium, and Arsenic in Mammalian Teratogenesis

Cited by 140 publications

References 10 publications

Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

Teratogenicity of metals to chick embryos

Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver

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