Interrelationships Between the Endocrine System and Neuropsychiatry

Michael, Richard P.; Gibbons, J. L.

doi:10.1016/s0074-7742(08)60597-8

Cited by 98 publications

(32 citation statements)

References 258 publications

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“…Dysfunction of the HPA axis is well described in the pathophysiology of stress-related disorders (Michael & Gibbson 1963, Holsboer 2000, 2001. Several clinical studies suggest that AVP could play an important role in the aetiology of these conditions and elevated plasma levels of AVP have been described in subjects suffering from depression (van Londen et al 1997, 2001, de Winter et al 2003 or post-traumatic stress disorders (de Kloet et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

Spiga¹,

Harrison²,

Wood³

et al. 2008

Journal of Endocrinology

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Vasopressin (AVP), produced in parvocellular neurons of the hypothalamic paraventricular nucleus, regulates, together with CRH, pituitary ACTH secretion. The pituitary actions of AVP are mediated through the G protein receptor V 1b (V 1b jR). In man, hyperactivity of the hypothalamicpituitary-adrenal axis has been associated with depression and other stress-related conditions. There are also clinical data suggesting a role for AVP in the dysfunctional HPA axis described in some depressed patients. In this study, we have investigated the effect of a recently synthesised selective antagonist of the V 1b R both on exogenous AVP-induced ACTH and corticosterone secretion, and on basal and stressinduced pituitary-adrenal activity. Adult male SpragueDawley rats treated with the V 1b R antagonist (Org, 30 mg/kg, s.c.) or vehicle (5% mulgofen in 0 . 9% saline, 2 ml/kg, s.c.). We found that blockade of the V 1b R reduced the increase in both ACTH and corticosterone secretion induced by AVP (100 ng, i.v.). The same treatment had no effect either on basal ACTH and corticosterone levels or on the ultradian or diurnal rhythms of corticosterone secretion. Acute administration of the V 1b R antagonist reduced ACTH secretion following both restraint and lipopolysaccharide, but did not antagonise the ACTH response to noise. The same treatment did not reduce corticosterone secretion in response to any of the three stressors used in this study. Our results confirm that this compound is an antagonist of the V 1b R in the rat, and that its ability to reduce stress-induced ACTH responses is stressor dependent with differential modulation of pituitary and adrenal responses.

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Section: Introductionmentioning

confidence: 99%

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

Spiga¹,

Harrison²,

Wood³

et al. 2008

Journal of Endocrinology

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“…15 Gibbons 16 corroborated this finding and added that the plasma levels of cortisol during remission of a depressive event were smaller during the acute phase of the disease. There are studies on the HPA axis activities in patients with depression that evidenced an enhanced cortisol response to ACTH stimulation; decreased cortisol response to hypoglycemia; decreased ACTH response to stimulation with CRH; and resistance to cortisol suppression by dexamethasone (in the test of dexamethasone suppression), which suggested a possible relation between suppression and depression severity.…”

Section: Hpa Axis Dysfunctions and Psychiatric Symptomsmentioning

confidence: 78%

O papel dos glicocorticóides na expressão dos sintomas de humor: uma revisão

Alheira

Brasil

2005

Rev. psiquiatr. Rio Gd. Sul

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O objetivo desta revisão é verificar, na literatura, uma relação entre níveis plasmáticos aumentados de corticosteróides e sintomas psiquiátricos, identificar as manifestações clínicas mais comuns e os tratamentos propostos. Alterações no eixo hipotálamo-hipófise-supra-renal levando a hipercortisolemia estariam associadas a distúrbios do humor, sobretudo depressão, enquanto que o uso de drogas glicocorticóides estaria relacionado ao aparecimento de sintomas psiquiátricos, como mania, depressão, labilidade afetiva e psicose. O levantamento bibliográfico foi realizado através dos indexadores Medline e Bireme no período de 1993 a 2003, em inglês, francês e espanhol, utilizando-se o cruzamento das seguintes palavras-chave: cortisol, corticosteróides, depressão, transtorno bipolar e psicose. Foram incluídos artigos originais (33) e de revisão (22) e excluídos relatos de caso. Alguns estudos sugerem que altas concentrações plasmáticas de cortisol, em longo prazo, podem levar à depressão, propondo que a utilização de drogas antiglicocorticóides teria efeito antidepressivo. Outros estudos, por outro lado, indicam não haver associação entre hipercortisolemia e episódios depressivos.

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“…Altered personality or states of consciousness are well-known consequences of disorders such as Cushing's syndrome, Addison's disease, and hyperthyroidism (Engel & Margolin, 1942;Michael & Gibbons, 1963). Estrogen itself can alter personality in a phenomenon familar to millions of women: premenstrual tension.…”

Section: Amenorrhea Low Lh Levelsmentioning

confidence: 99%

A possible neuroendocrine basis of two clinical syndromes: Anorexia nervosa and the Kleine-Levin syndrome

Young

1975

Psychobiology

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Interrelationships Between the Endocrine System and Neuropsychiatry

Cited by 98 publications

References 258 publications

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

Blockade of the V1b receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic–pituitary–adrenal axis activity

O papel dos glicocorticóides na expressão dos sintomas de humor: uma revisão

A possible neuroendocrine basis of two clinical syndromes: Anorexia nervosa and the Kleine-Levin syndrome

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