Interrelationship of the human intestinal flora and protein utilization

Oomen, H. A. P. C.

doi:10.1079/pns19700046

Cited by 35 publications

(15 citation statements)

References 11 publications

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“…Many investigators (1)(2)(3)(4)(5) have reported that the daily protein intake of these people is less than 40g and that most of the dietary protein is derived from customary vegetable foods.…”

mentioning

confidence: 99%

Studies on protein nutrition of Papua New Guinea highlanders: Nitrogen balance and hematological studies.

Fujita

Rikimaru

Okuda

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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mentioning

confidence: 99%

Studies on protein nutrition of Papua New Guinea highlanders: Nitrogen balance and hematological studies.

Fujita

Rikimaru

Okuda

et al. 1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Malcolm found a high mortality among infants (4), a slow rate of growth and a late onset of menarche among children in PNG highland (5,6), and suggested that these are adaptive responses to nutritional deficiency. With regard to the maintenance of healthy activities of the adults, Oomen (7) suggested that PNG highlanders may be capable of fixing nitrogen in the gastrointestinal tract and of utilizing it to maintain the nitrogen balance. Actually, Bergersen and Hipsley (8) isolated N-fixing bacteria (mainly Klebsiella aerogenes) from all 14 stool samples of PNG potato eaters, and 1 out of 9 Australian controls.…”

Section: Discussionmentioning

confidence: 99%

A pilot study on protein metabolism in the Papua New Guinea highlanders.

Tanaka

Kubo

Shiraki

et al. 1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryIn an attempt to clarify the nutritional enigma of the healthy strong physique of Papua New Guinea (PNG) highlanders who have a protein-deficient diet mainly composed of sweet potato, a pilot study was performed as follows with 10 volunteers of PNG highlanders, and with 8 Japanese controls, one group of whom took an experimental protein-deficient diet in Japan. 1. In 4 groups of subjects, i.e. adults of PNG highlanders, their children, Japanese controls who were having standard Japanese food (SPD), and those who were having a low protein diet (0.5g/kg) for 2 weeks (LPD), urea metabolism was investigated after oral administration of 15N urea. By tracing the cumulative excretion of 15N in urine successively for about 10 days after 15N urea administration, it was found that children of PNG highlanders can retain a large amount of 15N in the body, Japanese controls of LPD fairly well, PNG adult slightly and the Japanese controls of SPD the least of the four groups. It was demonstrated that the 15N atom% excess in the plasma protein of PNG adults, children, and Japanese control of LPD is maintained in the range of 0.02-0.05% fluctuating for 10 days after 15N urea administration. On the other hand, 15N atom% excess in plasma protein of Japanese control of SPD was within the scope of error (0.01%). 15N atom% excess in the lysine fraction of the hydrolysate of plasma protein was found in the range of 0.01-0.05% in a large number of cases of PNG subjects, and Japanese control of LPD, while it was not significantly detectable in Japanese

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“…Many investigators have reported that sweet-potato eaters of Papua New Guinea subsist on a low protein intake, but that they are not malnourished, and also have suggested the possibility that they undergo metabolic adaptation to a low protein intake (6)(7)(8)(9)(10)(11)(12). Based on the finding that urea can be utilized during protein deficiency, we postulated that an adaptation to a low protein intake by Papua New Guinea highlanders may be in the form of utilization of the nitrogen of endogenous urea.…”

Section: Discussionmentioning

confidence: 99%

Utilization of urea nitrogen in Papua New Guinea highlanders.

Rikimaru

Fujita

Okuda

et al. 1985

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe utilization of urea nitrogen was examined in 10 healthy adult men from a village near Lufa, in the Eastern Highlands Province of Papua New Guinea. The staple diet of these men was sweet potatoes .[15N]urea was used as tracer for urea released into their intestinal tracts and the utilization of the urea-N was estimated from the trend of 15N. The men were orally given [15N]urea at the beginning of the study and then their daily protein intake, serum protein levels, 15N excretion in the feces and urine, 15N retention in the whole body and 15N incorporation into serum protein were examined.

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Interrelationship of the human intestinal flora and protein utilization

Cited by 35 publications

References 11 publications

Studies on protein nutrition of Papua New Guinea highlanders: Nitrogen balance and hematological studies.

Studies on protein nutrition of Papua New Guinea highlanders: Nitrogen balance and hematological studies.

A pilot study on protein metabolism in the Papua New Guinea highlanders.

Utilization of urea nitrogen in Papua New Guinea highlanders.

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