Interrelationship of physical factors affecting sodium reabsorption in the dog

Daugharty, TM; Belleau, LJ; Martino, JA; Earley, Laurence E.

doi:10.1152/ajplegacy.1968.215.6.1442

Cited by 64 publications

(30 citation statements)

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“…In view of our findings that proximal reabsorption is depressed by saline, it seems likely that this effect is exerted at a distal site. This would imply that capillary pressure may be an important physical determinant of distal reabsorption, as has been postulated for the proximal tubule (21,22).…”

Section: Methodsmentioning

confidence: 89%

Proximal tubular function in dogs with thoracic caval constriction

Rb¹,

Alexander²,

Ng³

1971

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 89%

Proximal tubular function in dogs with thoracic caval constriction

Rb¹,

Alexander²,

Ng³

1971

J. Clin. Invest.

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“…This has led to the suggestion that the postulated natriuretic hormone has a very short half-life, an observation not in keeping with our present experiments. An alternate explanation might be that since the recepient animals were not allowed to become volume expanded there was less depression of proximal tubular reabsorption due to physical change in the postglomerular circulation (13). Then less sodium would be delivered to the more distal site of action of the natriuretic hormone.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that a hormone may be released which promotes renal sodium excretion (1, [8][9][10][11], perhaps by depressing proximal tubular sodium reabsorption (8,12). Recent studies also indicate that intrarenal physical changes in the postglomerular circulation (13)(14)(15) and possibly distributional changes in intrarenal blood flow (16)(17)(18) might be important in determining sodium excretion.…”

Section: Introductionmentioning

confidence: 99%

Natriuretic activity in plasma and urine of salt-loaded man and sheep

Je¹,

Jd²,

Jh³

1969

J. Clin. Invest.

149

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A B s T R A C T The present study was designed to examine the question of whether or not there is a natriuretic hormonal substance involved in the renal regulation of sodium balance.For this purpose, procedures for concentration and fractionation of plasma and urine samples and a sensitive bioassay for demonstrating changes in renal sodium excretion were developed. The natriuretic assay utilized rats with mild diabetes insipidus which were maintained in salt and water balance.Using these approaches a natriuretic humoral substance was demonstrated in plasma and urine from normal man and sheep, and in patients with primary aldosteronism or essential hypertension.It seems likely that this substance participates in day to day regulation of sodium balance because it was not detectable in sodium-depleted subjects and it consistently appeared in the sodium-loaded subjects.The hormonal agent may not act immediately and its activity can be apparent for up to 3 hr. Full expression of its activity requires that the assay animals be appropriately volume expanded. This suggests that the increases in sodium excretion mediated by this hormonal substance depend in part on the coparticipation of other physical and perhaps humoral factors.This natriuretic substance appears to be of large molecular weight or carried by a large molecule. The data suggest that it acts, at least in part, to block sodium reabsorption in a more distal portion of the tubule.

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“…Plasma volumes were determined in 10 BDL and 9 unoperated rats. After inulin and PAH clearances had been determined in the manner described earlier, carefully measured amounts (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) ACi) of radioiodinated ('I) human serum albumin (Abbott Laboratories, North Chicago, Ill.) were injected into the jugular vein. 60 min later, an arterial blood sample was drawn and the activity of 10 /Al of plasma was determined by liquid scintillation techniques, in an Iso/Cap 300 liquid scintillation system, with appropriate quenched standards and the scintillation solution described above.…”

Section: Methodsmentioning

confidence: 99%

“…Three phenomena thought to play a major role in altering the renal excretion of sodium are (a) changes in the glomerular filtration rate, (b) changes in the endogenous secretion of mineralocorticoids (3), and (c) renal hemodynamic adjustments, including disturbances in the intrarenal distribution of blood flow (5,6) and alterations of Starling forces within the peritubular circulation (12)(13)(14)(15). In the past, the possible interrelationship between the effects of these two hemodynamic adjustments has not been emphasized.…”

Section: Introductionmentioning

confidence: 99%

Intrarenal mechanisms of salt retention after bile duct ligation in rats.

Yarger¹,

Schrader²,

Boyd³

1976

J. Clin. Invest.

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A B S T R A C T In order to study renal salt-retaining mechanisms during the early stages of ascites formation, rats were subjected to bile duct ligation. After this procedure, plasma volumes were found to be reduced and hematocrits slightly increased. The whole-kidney glomerular filtration rate and plasma flows were reduced to 59 and 57% of control values, but the filtration fraction was unchanged. Absolute sodium excretion, as well as the fraction of the filtered sodium load excreted, was also significantly reduced.When micropuncture techniques were used to examine the function of single superficial nephrons, the glomerular filtration rate in these nephrons was found to be reduced to 70% of controlled values, and fractional reabsorption was found to be increased at all accessible sites along the nephron. Filtration by intermediate and juxtamedullary nephrons, determined by Hanssen's technique, was reduced to 55 and 48% of control values.By the use of radioactive microspheres, it was demonstrated that blood flow to superficial, intermediate, and juxtamedullary nephrons was reduced to 49, 59, and 73% of control values. Filtration by superficial nephrons decreased much more than plasma flow-a finding which suggests that the measured increase in fractional reabsorption was associated with an increase in the superficial nephron filtration fraction.From this study, it appears that two factors play an important part in the sodium retention observed in the initial stages of ascites formation following bile duct ligation in rats: (a) a decrease in the filtered sodium Several parts of this manuscript have previously appeared in abstract form (Clin. Res. 22: 52A and 551A) and were presented to the Southern Sectional Meeting of the Ameri-

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Interrelationship of physical factors affecting sodium reabsorption in the dog

Cited by 64 publications

References 0 publications

Proximal tubular function in dogs with thoracic caval constriction

Proximal tubular function in dogs with thoracic caval constriction

Natriuretic activity in plasma and urine of salt-loaded man and sheep

Intrarenal mechanisms of salt retention after bile duct ligation in rats.

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