Interrelationship of Photocarcinogenicity, Photomutagenicity and Phototoxicity

Loveday, Kenneth S.

doi:10.1111/j.1751-1097.1996.tb03044.x

Cited by 29 publications

(18 citation statements)

References 20 publications

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“…Possible associations with skin cancer risks were observed with consumption of parsnips (CMM) and with the use of thiazines (BCC), thiazide diuretics (SCC) and cardiac drugs (CMM), as is consistent with the known photosensitizing potential of these food items and drugs. [15][16][17][18][19][20][40][41][42] Of the food and drug associations studied, only a negative association with pomegranate and ciprofloxacin and a positive association with thiazide diuretics remained significant after correction for multiple testing, germane to previously reported association with increased risks of SCC, CMM and BCC. 42,46 When we further analysed the negative association with ciprofloxacin (Table 5), the numbers taking this antibiotic daily for more than 3 months were low (37 controls, 10 BCC, 7 SCC, 12 CMM) and were almost all from Italy, Germany and Poland.…”

Section: Discussionmentioning

confidence: 60%

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Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Vries

Trakatelli

Kalabalikis

et al. 2012

British Journal of Dermatology

140

111

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BACKGROUND: \ud \ud During recent years numerous studies have suggested that personal and environmental factors might influence cancer development.\ud \ud OBJECTIVES: \ud \ud To investigate environmental and personal characteristics associated with skin cancer risk.\ud \ud METHODS: \ud \ud A multicentre hospital-based case-control study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self-administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk.\ud \ud RESULTS: \ud \ud The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0·33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1·66). Ciprofloxacin was also associated with SCC (OR 0·34) and thiazines with BCC (OR 2·04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM.\ud \ud CONCLUSIONS: \ud \ud In this large case-control study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies

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Section: Discussionmentioning

confidence: 60%

“…Similarly, psoralens and other furanocoumarins (botanical phytoalexins) photochemically induce mutations leading to phototoxicity and photocarcinogenicity. [18][19][20] Various vegetables and citrus fruits have been shown to contain furanocoumarins and can therefore be photosensitizing. Indeed, their intake has been suggested to be related to CMM risk.…”

mentioning

confidence: 99%

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Vries

Trakatelli

Kalabalikis

et al. 2012

British Journal of Dermatology

140

111

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“…DOI 10.1002/em Tables I and II. development of antibiotic resistance [Pillai et al, 2001]. If the cellular repair mechanisms are overloaded, primary DNA damage may lead to mutations or chromosomal damage and eventually cause tumors [Loveday, 1996;Nataraj et al, 1996;Klecak et al, 1997]. The recommended therapeutic dose of lomefloxacin for humans is 400 mg once daily for 7-14 consecutive days.…”

Section: Discussionmentioning

confidence: 99%

Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin

Attia

2009

Environ and Mol Mutagen

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Classification of micronuclei induced by lomefloxacin, a difluorinated quinolone bactericidal agent, in mouse bone marrow was performed by fluorescence in situ hybridization using DNA probes for the centromere repeated minor satellite DNA and the telomeric hexamer repeat (5'-TTAGGG-3'). Colchicine and mitomycin C were used as a positive control aneugen and clastogen, respectively, and these compounds produced the expected responses. Single doses of 40, 80, 160, or 320 mg/kg lomefloxacin were given via oral intubations and bone marrow was sampled at 24 and 48 hr after treatment. The micronuclei showed significant increases in both sampling times after doses of 320 mg/kg. A statistically significant increase of micronuclei frequency was also detected for 160 mg/kg lomefloxacin at 48 hr after treatment. The responses were directly correlated with bone-marrow cytotoxicity. Following treatment with 160 and 320 mg/kg lomefloxacin, 48.2 and 50.0% of the induced micronuclei, respectively, showed double labeling with centromeric signals and several telomeric signals, indicating that the induced micronuclei were composed of whole chromosomes. Similarly, 51.8 and 50.0% of the induced micronuclei, respectively, were centromere-negative, demonstrating that lomefloxacin not only induces chromosome loss but also chromosome breakage. The results also showed that chromosomes can be enclosed in a micronucleus before and after centromere separation. Overall, this study provides the first evidence of the potential of lomefloxacin to induce aneugenic effect in mice. However, given the high doses used in this study, the clinical significance of this finding is uncertain.

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“…1994). Nevertheless both 8-methoxypsoralen and 5-methoxypsoralen are photomutagenic and photocarcinogenic compounds (Loveday 1996).…”

Section: Ihstrcrcrmentioning

confidence: 99%

“…Nevertheless, since phototoxicity does not provide information about photocarcinogenic activity, it is necessary to determine photomutagenicity, whose potency for psoralens agrees with that observed in photocarcinogenicity studies ( Loveday 1996). Furthermore.…”

Section: Tublementioning

confidence: 99%

Antiproliferative Activity and Phototoxicity of some Methyl Derivatives of 5–Methoxypsoralen and 5–Methoxyangelicin

Conconi

Montesi

Parnigotto

1998

Pharmacology & Toxicology

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Ihstrcrcr:The in vitro antiproliferative activity and in i t v o phototoxicity of some methyl derivatives of ~-methoxypsoraleit ,~n d 5-methoxyangelicin, i.e. 4,4'-dimethyl-5-methoxyangelicin (compound I), 3,4'-dimethyl-5-methoxyangelicin (compound 11). 4,4'-dimethyl-5-methoxypsoralen (compound 111); and 3.4'-dirnethyl-S-methoxypsoralen (compound lV), have been investigated. The effects of the compounds were evaluated in vi/ru on HL60 and A43 I cells, using 5-niethoxypsoralen ; I S the reference compound. In both cell lines compound 1, 11 and 111 showed better antiproliferative activity than coinpound 1V and 5-methoxypsordlen. Scanning electron microscopy revealed [hat all the compounds induced the formation of blebs and blisters on a A431 cell surface. Significant variations in the nuclear area strictly related to the toxicity of the compounds have been shown in both cell lines. Skin Irritancy in viiw was evaluated by mean of histopathological responses on guinea-pig skin. For each compound a damage index was determined by morphometrical analysis of empty spaces in the epidermis. Histopathology revealed skin phototoxicity of compounds which lacked erythemogenic activity by visual ,coring. By coupling cytotoxicity data in virro to skin sensitization ones in viva. compound I proved a promising candidate for use in clinical trials since due to a high inhibitory effect on the growth of human cell lines coupled to low skin phototoxicity.

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Interrelationship of Photocarcinogenicity, Photomutagenicity and Phototoxicity

Abstract: Enhancing effect of hutylated hydroxytoluene on the development of liver altered foci and neoplasma induced by N-2-fluorenylacetamide in rats. Food Chem. Toxicol. 22, 191-198. 32. Witschi, H. P. (1983)

Cited by 29 publications

References 20 publications

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin

Antiproliferative Activity and Phototoxicity of some Methyl Derivatives of 5–Methoxypsoralen and 5–Methoxyangelicin

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